KR910007928A - 신규 벤조[1,8] 나프티리딘 유도체, 그의 제조 및 그를 함유하는 조성물 - Google Patents
신규 벤조[1,8] 나프티리딘 유도체, 그의 제조 및 그를 함유하는 조성물 Download PDFInfo
- Publication number
- KR910007928A KR910007928A KR1019900017460A KR900017460A KR910007928A KR 910007928 A KR910007928 A KR 910007928A KR 1019900017460 A KR1019900017460 A KR 1019900017460A KR 900017460 A KR900017460 A KR 900017460A KR 910007928 A KR910007928 A KR 910007928A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- radical
- hydrogen atom
- naphthyridine
- hydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims 8
- BJVCSICIEDHBNI-UHFFFAOYSA-N benzo[b][1,8]naphthyridine Chemical class N1=CC=CC2=CC3=CC=CC=C3N=C21 BJVCSICIEDHBNI-UHFFFAOYSA-N 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- CGXLVFZJJOXEDF-UHFFFAOYSA-N 1,8-naphthyridine-3-carboxylic acid Chemical compound N1=CC=CC2=CC(C(=O)O)=CN=C21 CGXLVFZJJOXEDF-UHFFFAOYSA-N 0.000 claims 5
- -1 C 3-6 cycloalkyl radical Chemical class 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000001301 oxygen Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- 229910052717 sulfur Chemical group 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000004885 piperazines Chemical class 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Virology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8914203 | 1989-10-30 | ||
| FR8914203A FR2653663A1 (en) | 1989-10-30 | 1989-10-30 | Novel benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them |
| FR9008757A FR2664595B1 (fr) | 1990-07-10 | 1990-07-10 | Nouveaux derives de benzonaphtyridine-1,8, leur preparation et les compositions qui les contiennent. |
| FR9008757 | 1990-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR910007928A true KR910007928A (ko) | 1991-05-30 |
Family
ID=26227626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900017460A Ceased KR910007928A (ko) | 1989-10-30 | 1990-10-30 | 신규 벤조[1,8] 나프티리딘 유도체, 그의 제조 및 그를 함유하는 조성물 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5053509A (https=) |
| EP (1) | EP0431991B1 (https=) |
| JP (1) | JPH03151384A (https=) |
| KR (1) | KR910007928A (https=) |
| AT (1) | ATE100103T1 (https=) |
| AU (1) | AU629997B2 (https=) |
| BG (1) | BG60915B1 (https=) |
| CA (1) | CA2028730A1 (https=) |
| CZ (1) | CZ280513B6 (https=) |
| DE (1) | DE69005994T2 (https=) |
| DK (1) | DK0431991T3 (https=) |
| ES (1) | ES2062455T3 (https=) |
| FI (1) | FI92068C (https=) |
| HU (1) | HU208138B (https=) |
| IE (1) | IE65099B1 (https=) |
| IL (1) | IL96159A (https=) |
| NO (1) | NO175433C (https=) |
| NZ (1) | NZ235890A (https=) |
| PL (1) | PL164270B1 (https=) |
| PT (1) | PT95743B (https=) |
| RO (1) | RO108347B1 (https=) |
| RU (1) | RU2047613C1 (https=) |
| TW (1) | TW214550B (https=) |
| YU (1) | YU47694B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9309574B1 (en) | 1984-08-22 | 2016-04-12 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Molecular cloning of HIV-1 from immortalized cell lines |
| FR2681865B1 (fr) * | 1991-10-01 | 1993-11-19 | Bel Laboratoire Roger | Nouveaux derives de la benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent. |
| FR2703681B1 (fr) * | 1993-04-08 | 1995-05-12 | Bellon Labor Sa Roger | Procede de preparation de fluoro-6-halogeno-2 quinoleine |
| US5883098A (en) * | 1993-11-29 | 1999-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| US5714607A (en) * | 1995-12-01 | 1998-02-03 | American Cyanamid Company | Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide |
| DE19546249A1 (de) * | 1995-12-12 | 1997-06-19 | Bayer Ag | Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| UA67760C2 (uk) * | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| RU2160092C2 (ru) * | 1998-02-16 | 2000-12-10 | Рязанский областной клинический кожно-венерологический диспансер | Антимикробный препарат для лечения инфицированных ран |
| FR2787452B1 (fr) * | 1998-12-21 | 2004-10-22 | Aventis Pharma Sa | Nouveaux derives de la benzonaphtyridine-1,8, leur preparation et les compositions pharmaceutiques qui les contiennent |
| ES2216606T3 (es) * | 1998-12-21 | 2004-10-16 | Aventis Pharma S.A. | Derivados de la benzo-1,8-naftiridina. |
| FR2795729B1 (fr) * | 1999-06-30 | 2001-08-10 | Aventis Pharma Sa | Nouveaux derives de la benzo[f]naphtyridine, leur preparation et les compositions les contenant |
| JP2003503495A (ja) * | 1999-06-30 | 2003-01-28 | アベンテイス・フアルマ・ソシエテ・アノニム | 新規なベンゾ［ｆ］ナフチリジン誘導体、それらの製造およびそれらを含む組成物 |
| MY129850A (en) * | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| ATE517622T1 (de) * | 2003-10-27 | 2011-08-15 | Merck Sharp & Dohme | Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten |
| US8436176B2 (en) * | 2004-12-30 | 2013-05-07 | Medicis Pharmaceutical Corporation | Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine |
| KR101599524B1 (ko) * | 2015-07-31 | 2016-03-03 | (주)기억되는 사람들 | 유골함 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133885A (en) * | 1977-07-18 | 1979-01-09 | Merck & Co., Inc. | Substituted naphthyridinones |
| DE3420798A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren |
| EP0230053A3 (en) * | 1986-01-17 | 1988-03-30 | American Cyanamid Company | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| NZ232091A (en) * | 1989-01-16 | 1990-12-21 | Bellon Labor Sa Roger | 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof |
-
1990
- 1990-10-22 RO RO146164A patent/RO108347B1/ro unknown
- 1990-10-29 CA CA002028730A patent/CA2028730A1/fr not_active Abandoned
- 1990-10-29 DK DK90403047.5T patent/DK0431991T3/da active
- 1990-10-29 EP EP90403047A patent/EP0431991B1/fr not_active Expired - Lifetime
- 1990-10-29 PL PL90287563A patent/PL164270B1/pl unknown
- 1990-10-29 ES ES90403047T patent/ES2062455T3/es not_active Expired - Lifetime
- 1990-10-29 AT AT90403047T patent/ATE100103T1/de not_active IP Right Cessation
- 1990-10-29 FI FI905329A patent/FI92068C/fi not_active IP Right Cessation
- 1990-10-29 DE DE90403047T patent/DE69005994T2/de not_active Expired - Fee Related
- 1990-10-29 CZ CS905297A patent/CZ280513B6/cs unknown
- 1990-10-29 BG BG93114A patent/BG60915B1/bg unknown
- 1990-10-29 AU AU65551/90A patent/AU629997B2/en not_active Ceased
- 1990-10-29 NO NO904683A patent/NO175433C/no unknown
- 1990-10-29 IL IL9615990A patent/IL96159A/en not_active IP Right Cessation
- 1990-10-29 HU HU906926A patent/HU208138B/hu not_active IP Right Cessation
- 1990-10-30 KR KR1019900017460A patent/KR910007928A/ko not_active Ceased
- 1990-10-30 IE IE389790A patent/IE65099B1/en not_active IP Right Cessation
- 1990-10-30 US US07/605,340 patent/US5053509A/en not_active Expired - Fee Related
- 1990-10-30 NZ NZ235890A patent/NZ235890A/en unknown
- 1990-10-30 TW TW079109196A patent/TW214550B/zh active
- 1990-10-30 YU YU205390A patent/YU47694B/sh unknown
- 1990-10-30 PT PT95743A patent/PT95743B/pt not_active IP Right Cessation
- 1990-10-30 JP JP2293501A patent/JPH03151384A/ja active Pending
-
1992
- 1992-07-08 RU SU925011989A patent/RU2047613C1/ru active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19901030 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19950907 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19901030 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19980423 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19980707 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19980423 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |