KR910006979B1 - 1,3,4,5-테트라히드로벤즈[c,d]인돌, 이들의 제조 방법 및 이들을 유효 성분으로 하는 치료제 - Google Patents

1,3,4,5-테트라히드로벤즈[c,d]인돌, 이들의 제조 방법 및 이들을 유효 성분으로 하는 치료제 Download PDF

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Publication number
KR910006979B1
KR910006979B1 KR1019840008206A KR840008206A KR910006979B1 KR 910006979 B1 KR910006979 B1 KR 910006979B1 KR 1019840008206 A KR1019840008206 A KR 1019840008206A KR 840008206 A KR840008206 A KR 840008206A KR 910006979 B1 KR910006979 B1 KR 910006979B1
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KR
South Korea
Prior art keywords
compound
formula
reaction
iii
acid
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Expired
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KR1019840008206A
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English (en)
Korean (ko)
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KR850004462A (ko
Inventor
글라서 토마스
보도융에
트라버 에르그
알렌 게오르그
Original Assignee
트로폰베르케 게엠베하 운트 캄파니, 카게
하이레덴 야코비, 게르트 바디케
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Publication of KR850004462A publication Critical patent/KR850004462A/ko
Application granted granted Critical
Publication of KR910006979B1 publication Critical patent/KR910006979B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Detergent Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019840008206A 1983-12-23 1984-12-21 1,3,4,5-테트라히드로벤즈[c,d]인돌, 이들의 제조 방법 및 이들을 유효 성분으로 하는 치료제 Expired KR910006979B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3346573.8 1983-12-23
DE3346573A DE3346573A1 (de) 1983-12-23 1983-12-23 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
KR850004462A KR850004462A (ko) 1985-07-15
KR910006979B1 true KR910006979B1 (ko) 1991-09-14

Family

ID=6217791

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840008206A Expired KR910006979B1 (ko) 1983-12-23 1984-12-21 1,3,4,5-테트라히드로벤즈[c,d]인돌, 이들의 제조 방법 및 이들을 유효 성분으로 하는 치료제

Country Status (16)

Country Link
EP (1) EP0148440B1 (enExample)
JP (1) JPS60156670A (enExample)
KR (1) KR910006979B1 (enExample)
AT (1) ATE37711T1 (enExample)
AU (1) AU566758B2 (enExample)
DE (2) DE3346573A1 (enExample)
DK (1) DK157295C (enExample)
ES (2) ES8605237A1 (enExample)
FI (1) FI79299C (enExample)
GR (1) GR82577B (enExample)
IL (1) IL73875A (enExample)
NO (1) NO162615C (enExample)
NZ (1) NZ210665A (enExample)
PH (1) PH23272A (enExample)
PT (1) PT79750A (enExample)
ZA (1) ZA8410038B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983622A (en) * 1984-02-06 1991-01-08 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
US5026869A (en) * 1984-02-06 1991-06-25 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
CA1266482A1 (en) * 1984-05-24 1990-03-06 Carl Kaiser 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines
DE3525564A1 (de) * 1985-07-15 1987-02-05 Schering Ag Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5273975A (en) * 1989-06-09 1993-12-28 The Upjohn Company Heterocyclic amines having central nervous system activity
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5212319A (en) * 1990-02-26 1993-05-18 Eli Lilly And Company Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
US5258379A (en) * 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5096908A (en) * 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
US5340838A (en) * 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5347013A (en) * 1991-03-28 1994-09-13 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5648356A (en) * 1991-03-28 1997-07-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[CD]indoles
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
US5244911A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof
USRE40278E1 (en) 1993-07-27 2008-04-29 Pharmacia & Upjohn Company Heterocyclic amines having central nervous system activity
TW430660B (en) * 1996-05-30 2001-04-21 Mochida Pharm Co Ltd Novel benzindole derivatives for neuron cell protection, processes for production, and the pharmaceutical compounds containing them
US7074927B2 (en) 1999-05-13 2006-07-11 Pharmacia & Upjohn Company Heterocyclic amines having central nervous system activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194811A (en) * 1963-09-05 1965-07-13 Merck & Co Inc Aroyl-benzindolyl acids
CH517732A (de) * 1969-10-24 1972-01-15 Sandoz Ag Verfahren zur Herstellung neuer Guanidin- Verbindungen
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4282240A (en) * 1979-11-23 1981-08-04 Merck & Co., Inc. Amino substituted tetrahydrobenzindoles
FR2522658A1 (fr) * 1982-03-05 1983-09-09 Roussel Uclaf Application a titre de medicaments de derives du trans 4-amino benz (c,d) indol-5-ol ainsi que de leurs sels, compositions les renfermant, nouveaux derives et leur procede de preparation
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
CA1266482A1 (en) * 1984-05-24 1990-03-06 Carl Kaiser 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines

Also Published As

Publication number Publication date
FI79299B (fi) 1989-08-31
FI79299C (fi) 1989-12-11
AU566758B2 (en) 1987-10-29
ES538290A0 (es) 1986-03-16
DK625584D0 (da) 1984-12-21
AU3690484A (en) 1985-07-04
IL73875A (en) 1988-08-31
ZA8410038B (en) 1985-08-28
ES8605237A1 (es) 1986-03-16
DE3346573A1 (de) 1985-07-04
FI845070L (fi) 1985-06-24
ES549978A0 (es) 1986-12-01
IL73875A0 (en) 1985-03-31
JPS60156670A (ja) 1985-08-16
NO162615C (no) 1990-01-24
DK157295C (da) 1990-05-07
GR82577B (en) 1985-04-23
ATE37711T1 (de) 1988-10-15
PT79750A (en) 1985-01-01
EP0148440B1 (de) 1988-10-05
JPH0475909B2 (enExample) 1992-12-02
DK157295B (da) 1989-12-04
FI845070A0 (fi) 1984-12-20
KR850004462A (ko) 1985-07-15
NO162615B (no) 1989-10-16
DK625584A (da) 1985-06-24
PH23272A (en) 1989-06-23
EP0148440A1 (de) 1985-07-17
DE3474444D1 (en) 1988-11-10
NZ210665A (en) 1988-06-30
NO844868L (no) 1985-06-24
ES8701721A1 (es) 1986-12-01

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