ES8701721A1 - Procedimiento para la obtencion de tetrahidrobenzindoles - Google Patents
Procedimiento para la obtencion de tetrahidrobenzindolesInfo
- Publication number
- ES8701721A1 ES8701721A1 ES549978A ES549978A ES8701721A1 ES 8701721 A1 ES8701721 A1 ES 8701721A1 ES 549978 A ES549978 A ES 549978A ES 549978 A ES549978 A ES 549978A ES 8701721 A1 ES8701721 A1 ES 8701721A1
- Authority
- ES
- Spain
- Prior art keywords
- tetrahydrobenzo
- indoles
- preparation
- alkyl
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Detergent Compositions (AREA)
- Fats And Perfumes (AREA)
- Luminescent Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE TETRAHIDROBENZINDOLES DE FORMULA GENERAL (I). SE REDUCEN COMPUESTOS DE FORMULA (II) PARA DAR LAS CORRESPONDIENTES ANILINAS, Y ESTAS SE TRANSFORMAN EN ISONITRILOS DE FORMULA (III), QUE, FINALMENTE, SE CICLAN CON UNA BASE FUERTE PARA DAR TETRAHIDROBENZINDONES DE FORMULA (I). POR SU ACCION SOBRE EL SISTEMA SEROTONINERGICO PUEDEN APLICARSE EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES Y DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3346573A DE3346573A1 (de) | 1983-12-23 | 1983-12-23 | 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES549978A0 ES549978A0 (es) | 1986-12-01 |
ES8701721A1 true ES8701721A1 (es) | 1986-12-01 |
Family
ID=6217791
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538290A Expired ES8605237A1 (es) | 1983-12-23 | 1984-12-05 | Procedimiento para la obtencion de tetrahidrobenzindoles |
ES549978A Expired ES8701721A1 (es) | 1983-12-23 | 1985-12-16 | Procedimiento para la obtencion de tetrahidrobenzindoles |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538290A Expired ES8605237A1 (es) | 1983-12-23 | 1984-12-05 | Procedimiento para la obtencion de tetrahidrobenzindoles |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0148440B1 (es) |
JP (1) | JPS60156670A (es) |
KR (1) | KR910006979B1 (es) |
AT (1) | ATE37711T1 (es) |
AU (1) | AU566758B2 (es) |
DE (2) | DE3346573A1 (es) |
DK (1) | DK157295C (es) |
ES (2) | ES8605237A1 (es) |
FI (1) | FI79299C (es) |
GR (1) | GR82577B (es) |
IL (1) | IL73875A (es) |
NO (1) | NO162615C (es) |
NZ (1) | NZ210665A (es) |
PH (1) | PH23272A (es) |
PT (1) | PT79750A (es) |
ZA (1) | ZA8410038B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL74222A (en) * | 1984-02-06 | 1988-07-31 | Lilly Co Eli | 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them |
US4983622A (en) * | 1984-02-06 | 1991-01-08 | Eli Lilly And Company | 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles |
US5026869A (en) * | 1984-02-06 | 1991-06-25 | Eli Lilly And Company | 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles |
CA1266482A1 (en) * | 1984-05-24 | 1990-03-06 | Carl Kaiser | 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines |
DE3525564A1 (de) * | 1985-07-15 | 1987-02-05 | Schering Ag | Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
US4745126A (en) * | 1987-03-12 | 1988-05-17 | Eli Lilly And Company | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides |
DE3809155A1 (de) * | 1988-03-18 | 1989-09-28 | Bayer Ag | 1,3,4,5-tetrahydrobenz-(c,d)-indole |
US5204340A (en) * | 1989-04-11 | 1993-04-20 | Eli Lilly And Company | Tetrahydrobenz(c,d)indole serotonin agonists |
US5273975A (en) * | 1989-06-09 | 1993-12-28 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
US5212319A (en) * | 1990-02-26 | 1993-05-18 | Eli Lilly And Company | Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor |
US5302612A (en) * | 1990-02-26 | 1994-04-12 | Eli Lilly And Company | 6-substituted-hexahydrobenz[cd]indoles |
US5340838A (en) * | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
US5258379A (en) * | 1990-05-04 | 1993-11-02 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with n-arylpiperazines |
US5096908A (en) * | 1990-05-04 | 1992-03-17 | Eli Lilly And Company | Method of inhibiting gastric acid secretion |
US5229409A (en) * | 1990-08-15 | 1993-07-20 | Eli Lilly And Company | 6-substituted-tetrahydrobenz[cd]indoles |
US5229410A (en) * | 1990-08-15 | 1993-07-20 | Eli Lilly And Company | 6-substituted-hexahydrobenz[cd]indoles |
US5244912A (en) * | 1991-03-28 | 1993-09-14 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof |
US5643934A (en) * | 1991-03-28 | 1997-07-01 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles |
US5244911A (en) * | 1991-03-28 | 1993-09-14 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof |
US5364856A (en) * | 1991-03-28 | 1994-11-15 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles |
US5347013A (en) * | 1991-03-28 | 1994-09-13 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles |
WO1995004056A1 (en) | 1993-07-27 | 1995-02-09 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
TW430660B (en) * | 1996-05-30 | 2001-04-21 | Mochida Pharm Co Ltd | Novel benzindole derivatives for neuron cell protection, processes for production, and the pharmaceutical compounds containing them |
US7074927B2 (en) | 1999-05-13 | 2006-07-11 | Pharmacia & Upjohn Company | Heterocyclic amines having central nervous system activity |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3194811A (en) * | 1963-09-05 | 1965-07-13 | Merck & Co Inc | Aroyl-benzindolyl acids |
CH517732A (de) * | 1969-10-24 | 1972-01-15 | Sandoz Ag | Verfahren zur Herstellung neuer Guanidin- Verbindungen |
US4110339A (en) * | 1977-11-25 | 1978-08-29 | Eli Lilly And Company | 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole |
US4282240A (en) * | 1979-11-23 | 1981-08-04 | Merck & Co., Inc. | Amino substituted tetrahydrobenzindoles |
FR2522658A1 (fr) * | 1982-03-05 | 1983-09-09 | Roussel Uclaf | Application a titre de medicaments de derives du trans 4-amino benz (c,d) indol-5-ol ainsi que de leurs sels, compositions les renfermant, nouveaux derives et leur procede de preparation |
IL74222A (en) * | 1984-02-06 | 1988-07-31 | Lilly Co Eli | 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them |
CA1266482A1 (en) * | 1984-05-24 | 1990-03-06 | Carl Kaiser | 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines |
-
1983
- 1983-12-23 DE DE3346573A patent/DE3346573A1/de not_active Withdrawn
-
1984
- 1984-12-05 ES ES538290A patent/ES8605237A1/es not_active Expired
- 1984-12-05 NO NO844868A patent/NO162615C/no unknown
- 1984-12-12 AT AT84115218T patent/ATE37711T1/de not_active IP Right Cessation
- 1984-12-12 DE DE8484115218T patent/DE3474444D1/de not_active Expired
- 1984-12-12 EP EP84115218A patent/EP0148440B1/de not_active Expired
- 1984-12-17 AU AU36904/84A patent/AU566758B2/en not_active Ceased
- 1984-12-17 PH PH31592A patent/PH23272A/en unknown
- 1984-12-19 JP JP59266500A patent/JPS60156670A/ja active Granted
- 1984-12-20 FI FI845070A patent/FI79299C/fi not_active IP Right Cessation
- 1984-12-20 IL IL73875A patent/IL73875A/xx unknown
- 1984-12-20 NZ NZ210665A patent/NZ210665A/xx unknown
- 1984-12-21 PT PT79750A patent/PT79750A/pt not_active IP Right Cessation
- 1984-12-21 GR GR82577A patent/GR82577B/el unknown
- 1984-12-21 KR KR1019840008206A patent/KR910006979B1/ko not_active IP Right Cessation
- 1984-12-21 DK DK625584A patent/DK157295C/da not_active IP Right Cessation
- 1984-12-21 ZA ZA8410038A patent/ZA8410038B/xx unknown
-
1985
- 1985-12-16 ES ES549978A patent/ES8701721A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES549978A0 (es) | 1986-12-01 |
AU566758B2 (en) | 1987-10-29 |
PH23272A (en) | 1989-06-23 |
FI79299B (fi) | 1989-08-31 |
NO844868L (no) | 1985-06-24 |
GR82577B (en) | 1985-04-23 |
JPH0475909B2 (es) | 1992-12-02 |
EP0148440A1 (de) | 1985-07-17 |
ES538290A0 (es) | 1986-03-16 |
DE3474444D1 (en) | 1988-11-10 |
DK157295B (da) | 1989-12-04 |
ES8605237A1 (es) | 1986-03-16 |
FI845070L (fi) | 1985-06-24 |
EP0148440B1 (de) | 1988-10-05 |
PT79750A (en) | 1985-01-01 |
DK625584A (da) | 1985-06-24 |
JPS60156670A (ja) | 1985-08-16 |
FI845070A0 (fi) | 1984-12-20 |
ZA8410038B (en) | 1985-08-28 |
NZ210665A (en) | 1988-06-30 |
KR850004462A (ko) | 1985-07-15 |
KR910006979B1 (ko) | 1991-09-14 |
NO162615B (no) | 1989-10-16 |
IL73875A (en) | 1988-08-31 |
NO162615C (no) | 1990-01-24 |
DK625584D0 (da) | 1984-12-21 |
DK157295C (da) | 1990-05-07 |
IL73875A0 (en) | 1985-03-31 |
DE3346573A1 (de) | 1985-07-04 |
ATE37711T1 (de) | 1988-10-15 |
FI79299C (fi) | 1989-12-11 |
AU3690484A (en) | 1985-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |