AU651621B2 - New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing them - Google Patents
New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing themInfo
- Publication number
- AU651621B2 AU651621B2 AU85076/91A AU8507691A AU651621B2 AU 651621 B2 AU651621 B2 AU 651621B2 AU 85076/91 A AU85076/91 A AU 85076/91A AU 8507691 A AU8507691 A AU 8507691A AU 651621 B2 AU651621 B2 AU 651621B2
- Authority
- AU
- Australia
- Prior art keywords
- preparing
- group
- drugs containing
- beta
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention concerns compounds of formula (I), in which SP is a spacer, Z is a valency bond, (a), (b), NH or S, A is hydrogen, a hydroxy group or an amino group which may be substituted by a lower-alkyl group, alk is a straight-chain or branched-chain alkylene group with 1-6 carbon atoms, R7? is hydrogen or a lower-alkyle group. The invention also concerns pharmacologically safe salts of such compounds, a method of preparing them, and drugs containing them for the treatment of osteoporosis.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4029499 | 1990-09-18 | ||
DE4029499A DE4029499A1 (en) | 1990-09-18 | 1990-09-18 | NEW 17- (BETA) -OESTRADIOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
PCT/EP1991/001757 WO1992005187A1 (en) | 1990-09-18 | 1991-09-14 | NEW 17-β-OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM |
Publications (2)
Publication Number | Publication Date |
---|---|
AU8507691A AU8507691A (en) | 1992-04-15 |
AU651621B2 true AU651621B2 (en) | 1994-07-28 |
Family
ID=6414440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU85076/91A Ceased AU651621B2 (en) | 1990-09-18 | 1991-09-14 | New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing them |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0549645B1 (en) |
JP (1) | JPH06500777A (en) |
KR (1) | KR930702378A (en) |
AT (1) | ATE110737T1 (en) |
AU (1) | AU651621B2 (en) |
CA (1) | CA2091268A1 (en) |
DE (2) | DE4029499A1 (en) |
FI (1) | FI931188A0 (en) |
HU (1) | HUT63435A (en) |
TW (1) | TW206971B (en) |
WO (1) | WO1992005187A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2746041B2 (en) * | 1992-02-14 | 1998-04-28 | 三菱化学株式会社 | New steroid derivatives |
US6399592B1 (en) | 1992-12-23 | 2002-06-04 | Merck & Co., Inc. | Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss |
JPH08505142A (en) * | 1992-12-23 | 1996-06-04 | メルク エンド カンパニー インコーポレーテッド | Bisphosphonate / estrogen therapy for treating and preventing bone loss |
GB9613722D0 (en) * | 1996-06-28 | 1996-08-28 | Univ Liverpool | Chemical compounds |
WO2015006691A1 (en) | 2013-07-11 | 2015-01-15 | Evestra, Inc. | Pro-drug forming compounds |
MX2020003470A (en) | 2017-10-19 | 2020-10-01 | Evestra Inc | Longer-acting progestin prodrug contraceptives. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK224589A (en) * | 1988-05-09 | 1989-11-10 | Merck & Co Inc | POLYMALONIC ACID COMPOUND AND PHARMACEUTICAL PREPARATION CONTAINING SUCH A CONNECTION |
-
1990
- 1990-09-18 DE DE4029499A patent/DE4029499A1/en not_active Withdrawn
-
1991
- 1991-09-14 JP JP3514892A patent/JPH06500777A/en active Pending
- 1991-09-14 WO PCT/EP1991/001757 patent/WO1992005187A1/en active IP Right Grant
- 1991-09-14 AU AU85076/91A patent/AU651621B2/en not_active Ceased
- 1991-09-14 HU HU93761A patent/HUT63435A/en unknown
- 1991-09-14 AT AT91916476T patent/ATE110737T1/en not_active IP Right Cessation
- 1991-09-14 KR KR1019930700800A patent/KR930702378A/en not_active Application Discontinuation
- 1991-09-14 DE DE59102769T patent/DE59102769D1/en not_active Expired - Fee Related
- 1991-09-14 EP EP91916476A patent/EP0549645B1/en not_active Expired - Lifetime
- 1991-09-14 CA CA002091268A patent/CA2091268A1/en not_active Abandoned
-
1992
- 1992-02-12 TW TW081100981A patent/TW206971B/zh active
-
1993
- 1993-03-17 FI FI931188A patent/FI931188A0/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0549645B1 (en) | 1994-08-31 |
JPH06500777A (en) | 1994-01-27 |
DE59102769D1 (en) | 1994-10-06 |
CA2091268A1 (en) | 1992-03-19 |
AU8507691A (en) | 1992-04-15 |
DE4029499A1 (en) | 1992-03-19 |
FI931188A (en) | 1993-03-17 |
HUT63435A (en) | 1993-08-30 |
EP0549645A1 (en) | 1993-07-07 |
WO1992005187A1 (en) | 1992-04-02 |
FI931188A0 (en) | 1993-03-17 |
ATE110737T1 (en) | 1994-09-15 |
KR930702378A (en) | 1993-09-08 |
TW206971B (en) | 1993-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |