AU8507691A - New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing them - Google Patents

New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing them

Info

Publication number
AU8507691A
AU8507691A AU85076/91A AU8507691A AU8507691A AU 8507691 A AU8507691 A AU 8507691A AU 85076/91 A AU85076/91 A AU 85076/91A AU 8507691 A AU8507691 A AU 8507691A AU 8507691 A AU8507691 A AU 8507691A
Authority
AU
Australia
Prior art keywords
preparing
group
drugs containing
beta
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU85076/91A
Other versions
AU651621B2 (en
Inventor
Frieder Bauss
Elmar Bosies
Angelika Esswein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU8507691A publication Critical patent/AU8507691A/en
Application granted granted Critical
Publication of AU651621B2 publication Critical patent/AU651621B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention concerns compounds of formula (I), in which SP is a spacer, Z is a valency bond, (a), (b), NH or S, A is hydrogen, a hydroxy group or an amino group which may be substituted by a lower-alkyl group, alk is a straight-chain or branched-chain alkylene group with 1-6 carbon atoms, R7? is hydrogen or a lower-alkyle group. The invention also concerns pharmacologically safe salts of such compounds, a method of preparing them, and drugs containing them for the treatment of osteoporosis.
AU85076/91A 1990-09-18 1991-09-14 New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing them Ceased AU651621B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4029499 1990-09-18
DE4029499A DE4029499A1 (en) 1990-09-18 1990-09-18 NEW 17- (BETA) -OESTRADIOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
PCT/EP1991/001757 WO1992005187A1 (en) 1990-09-18 1991-09-14 NEW 17-β-OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM

Publications (2)

Publication Number Publication Date
AU8507691A true AU8507691A (en) 1992-04-15
AU651621B2 AU651621B2 (en) 1994-07-28

Family

ID=6414440

Family Applications (1)

Application Number Title Priority Date Filing Date
AU85076/91A Ceased AU651621B2 (en) 1990-09-18 1991-09-14 New 17-beta-oestradiol derivatives, a method of preparing them, and drugs containing them

Country Status (11)

Country Link
EP (1) EP0549645B1 (en)
JP (1) JPH06500777A (en)
KR (1) KR930702378A (en)
AT (1) ATE110737T1 (en)
AU (1) AU651621B2 (en)
CA (1) CA2091268A1 (en)
DE (2) DE4029499A1 (en)
FI (1) FI931188A0 (en)
HU (1) HUT63435A (en)
TW (1) TW206971B (en)
WO (1) WO1992005187A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2746041B2 (en) * 1992-02-14 1998-04-28 三菱化学株式会社 New steroid derivatives
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
JPH08505142A (en) * 1992-12-23 1996-06-04 メルク エンド カンパニー インコーポレーテッド Bisphosphonate / estrogen therapy for treating and preventing bone loss
GB9613722D0 (en) * 1996-06-28 1996-08-28 Univ Liverpool Chemical compounds
WO2015006691A1 (en) 2013-07-11 2015-01-15 Evestra, Inc. Pro-drug forming compounds
MX2020003470A (en) 2017-10-19 2020-10-01 Evestra Inc Longer-acting progestin prodrug contraceptives.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK224589A (en) * 1988-05-09 1989-11-10 Merck & Co Inc POLYMALONIC ACID COMPOUND AND PHARMACEUTICAL PREPARATION CONTAINING SUCH A CONNECTION

Also Published As

Publication number Publication date
EP0549645B1 (en) 1994-08-31
JPH06500777A (en) 1994-01-27
DE59102769D1 (en) 1994-10-06
CA2091268A1 (en) 1992-03-19
DE4029499A1 (en) 1992-03-19
FI931188A (en) 1993-03-17
HUT63435A (en) 1993-08-30
EP0549645A1 (en) 1993-07-07
WO1992005187A1 (en) 1992-04-02
FI931188A0 (en) 1993-03-17
AU651621B2 (en) 1994-07-28
ATE110737T1 (en) 1994-09-15
KR930702378A (en) 1993-09-08
TW206971B (en) 1993-06-01

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired