KR910006219A - 벤즈아닐리드 유도체 및 그의 제조방법 - Google Patents

벤즈아닐리드 유도체 및 그의 제조방법 Download PDF

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KR910006219A
KR910006219A KR1019900015212A KR900015212A KR910006219A KR 910006219 A KR910006219 A KR 910006219A KR 1019900015212 A KR1019900015212 A KR 1019900015212A KR 900015212 A KR900015212 A KR 900015212A KR 910006219 A KR910006219 A KR 910006219A
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benzamide
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윌리엄 브릿지 앤드류
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원본미기재
로오느-푸우랜크 상뜨
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Abstract

내용 없음

Description

벤즈아닐리드 유도체 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식(I)의 벤즈아닐리드 유도체:
    여기에서 R1은 임의적으로 하나 이상의 탄소-탄소 이중 또는 삼중 결합을 함유하고 임의적으로 하나 이상의 헤테로 원자가 사이에 끼는 C4-18-직쇄 또는 분지쇄 알킬기이며;R2는 수소, 메틸, 또는 에틸이고;R3는 할로겐원자 또는 C1-5의 직쇄 또는 분지쇄 알킬기이거나 화학식 -OY 또는 -SOnY의 기이거나 디메틸 아미노기이며;R4및 R5는 각각 독립적으로 수소, 임의적으로 하나이상의 탄소-탄소 이중 또는 삼중결합을 함유하는 C1-6의 직쇄 또는 분지쇄 알킬기 또는 화학식 -(CH2)m-Z의 기이며 여기에서 (i) Z는 화학식 -OCH3, SOqCH3또는 -N(CH3)2의 기 또는 C1-3의 알카노일아미노기이고 m은 2,3 또는 4이거나; 또는 ii)Z는 헤테로 시클릴기이고 m은 0,1,2,3 또는 4이고;X는 산소 원자 또는 화학식 -OCH2-, -SOP-,-SOPCH2-, 또는, -NR6-의 기이고;R6은 수소, 메틸, 또는 에틸, 또는 아실기이고;Y는 C1-4의 직쇄 또는 분지쇄 알킬기이고;n,p 및 q는 각각 독립적으로 0,1 또는 2이다.
  2. 제1항에 있어서, R1이 C4-18의 직쇄 또는 분지쇄 알킬 또는 알케닐기이고;R3는 C1-5의 직쇄 또는 분지쇄 알킬기이거나 화학식 -OY 또는 -SOnY의 기이거나 또는 디메틸아미노기이며;R4및 R5는 Z이 알카노일아미노 이외의 것이라는 것만을 제외하고는 전술한 바와 같으며, R2,X,R6,Y,n,p 및 q는 제1항에서 정의한 바와 같은 화합물.
  3. 제1항 또는 제2항에 있어서, R1을 정의하는데 있어서의 헤테로 원자가 산소 황 또는 질소인 화합물.
  4. 제1항 내지 제3항중 어느 한항에 있어서, R3를 정의하는데 있어서의 할로겐 원자가 염소 또는 불소인 화합물.
  5. 제1항 내지 제4항중 어느 한항에 있어서, Z이 임의적으로 하나이상의 C1-4알킬기를 함유하고, 질소, 산소 및 황으로 부터 선택한 적어도 하나의 원자를 포함하며 고리내에 C5-8을 함유하는 헤테로시클릴 기인 화합물.
  6. 제1항 내지 제5항중 어느 한항에 있어서, R6으로 표시되는 아실기가 임의적으로 하나이상의 할로겐 원자로 치환된 C2-4의 알카노일 기인 화합물.
  7. 제1항 내지 제6항중 어느 한 항에 있어서, Z로 표시되는 헤테로시클릴기가, 임의적으로 하나 또는 두개의 메틸 또는 에틸기를 함유하는, 피리딜, 푸릴, 티아디아졸일, 모르폴리닐, 피페리디닐, 이소티아졸일 또는 피롤리디닐인 화합물.
  8. 제1항 내지 제7항중 어느 한항에 있어서, 하기 특성(1)-(6)중 하나 이상을 나타내는 화합물:
    (1)R1이 C5-16의 알킬기이고; (2)R2가 수소이고; (3)R3가 메톡시 또는 메틸티오이고; (4)R4가 소수이고; (5)R5가 (i)C1-5의 알킬기; 또는 (ⅱ)이 2 또는 3이고 Z이 메톡시 또는 메틸티오인 화학식 -(CH2)m-Z의 기이고/거나; (6)X는 산소 또는 황원자이고; 다른 부호는 제1항 내지 제7항중 어느 한 항에서 정의한 바와 같다.
  9. 제1항에 있어서, N-[2-메틸티오-5-2(메톡시에틸아미노 카르보닐)]-페닐-4-데실옥시벤즈아미드; N-(2-메틸티오-5-부틸아미노카르보닐)페닐-4-데실옥시벤즈아미드; N-[2-메틸티오에틸아미노-카르보닐] 페닐-4-데실옥시벤즈아미드; N-(2-메틸티오-5-부틸아미노카르보닐)페닐-4-데실옥시벤즈아미드; N-[2-메틸티오에틸아미노-카르보닐]페닐-4-(데실티오)벤즈아미드; N-[2-메틸티오에틸아미노-카르보닐] 페닐-4-데실옥시벤즈아미드; N-[2-메틸티오에틸아미노-카르보닐]페닐-4-노닐옥시벤즈아미드; N-(2-메톡시-5-부틸아미노카르보닐)-4-(데실티오)벤즈아미드; N-부틸-4-메틸-3-[4-(3,6,9-트옥사테실옥시 벤즈아미드)]벤즈아미드; 3-[4-(N-데실)트리플루오로아세트아미도]벤즈아미도-4-메톡시-N-(2-메틸티오에틸)벤즈아미드; 또는 3-(4-데실아미노벤즈아미도)-4-메톡시-N-(2-메틸티오에틸)벤즈아미드인 화합물.
  10. 하기 일반식(Ⅱ)의 아닐린:
    (여기에서 부호들은 제1항에서 정의한 바와 같다.)을 하기 일반식(Ⅲ)의 화합물:
    (여기에서 R1및 X는 제1항에서 정의한 바와 같으며 Z1은 할로겐 원자 또는 알콕시카르보닐옥시기이다)과 또는 하기 일반식(Ⅳ)의 안하이드라이드:
    (여기에서 R1및 X는 제1항에서 정의한 바와 같다)와 반응시키고, 임의적으로 이후에 일반식(I)의 화합물 일반식(I)의 다른 화합물로 전환시키는 것으로 구성되는, 제1항에 따르는 화합물의 제조 방법.
  11. 제약학적으로 허용가능한 희석제 또는 담체와 결합한 제1항에 정의되어 있는 일반식(I)의 벤즈 아닐리드 유도체로 구성되는 제약학적 조성물.
  12. 약제로서 사용하기 위한 제1항에 정의된 바와 같은 일반식(I)의 벤즈아닐리드 유도체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900015212A 1989-09-27 1990-09-25 벤즈아닐리드 유도체 및 그의 제조방법 KR910006219A (ko)

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PL (1) PL163034B1 (ko)
PT (1) PT95439A (ko)
RU (1) RU2007389C1 (ko)
ZA (1) ZA907639B (ko)

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GB9016581D0 (en) * 1990-07-27 1990-09-12 Ici Plc Fungicides
GB9017710D0 (en) * 1990-08-13 1990-09-26 May & Baker Ltd New compositions of matter
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
US5534529A (en) * 1993-06-30 1996-07-09 Sankyo Company, Limited Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
GB9408185D0 (en) * 1994-04-25 1994-06-15 Fujisawa Pharmaceutical Co New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
FR2946345B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946342B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946346B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946340B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.

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GB1438612A (en) * 1974-02-08 1976-06-09 Biorex Laboratories Ltd Glycyrrhetinic acid derivatives
AU547405B2 (en) * 1981-07-08 1985-10-17 Sanofi Amidobenzamides
US4500714A (en) * 1981-10-15 1985-02-19 Chugai Seiyaku Kabushiki Kaisha 3-Substituted-ureido-N-pyridyl benzamides
AU567140B2 (en) * 1984-01-06 1987-11-12 Shionogi & Co., Ltd. Sulphonamido-benzamide derivatives
LU86258A1 (fr) * 1986-01-21 1987-09-03 Rech Dermatologiques C I R D S Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
US4835181A (en) * 1987-02-18 1989-05-30 Eli Lilly And Company Anticonvulsant agents using cyano dimethylphenyl benzamides

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Publication number Publication date
PT95439A (pt) 1991-05-22
DE69012040T2 (de) 1995-01-05
DE69012040D1 (de) 1994-10-06
PL287073A1 (en) 1991-11-04
FI904728A0 (fi) 1990-09-26
US5159114A (en) 1992-10-27
JPH03178954A (ja) 1991-08-02
HU906230D0 (en) 1991-03-28
DK0424194T3 (da) 1994-10-03
MX9203712A (es) 1992-07-01
PL163034B1 (pl) 1994-02-28
NZ235454A (en) 1992-04-28
IE903448A1 (en) 1991-04-10
EP0424194A2 (en) 1991-04-24
EP0424194A3 (en) 1991-09-25
DD295344A5 (de) 1991-10-31
AU6313390A (en) 1991-04-11
EP0424194B1 (en) 1994-08-31
RU2007389C1 (ru) 1994-02-15
CA2026273A1 (en) 1991-03-28
ZA907639B (en) 1991-07-31
ATE110715T1 (de) 1994-09-15
CS465690A3 (en) 1992-04-15
NO904187L (no) 1991-04-02
IL95762A0 (en) 1991-06-30
AU641686B2 (en) 1993-09-30
ES2058849T3 (es) 1994-11-01
GB8921792D0 (en) 1989-11-08
NO904187D0 (no) 1990-09-26
HUT55349A (en) 1991-05-28
NO173057B (no) 1993-07-12
NO173057C (no) 1993-10-20
HU207839B (en) 1993-06-28

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