KR910019978A - 스피로 디벤조수베란 유도체 - Google Patents

스피로 디벤조수베란 유도체 Download PDF

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Publication number
KR910019978A
KR910019978A KR1019910007257A KR910007257A KR910019978A KR 910019978 A KR910019978 A KR 910019978A KR 1019910007257 A KR1019910007257 A KR 1019910007257A KR 910007257 A KR910007257 A KR 910007257A KR 910019978 A KR910019978 A KR 910019978A
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KR
South Korea
Prior art keywords
compound
hydrogen
alkyl
spiro
dibenzosuberan
Prior art date
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KR1019910007257A
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English (en)
Inventor
히로무 마쓰무라
마꼬또 아다찌
도시사다 야노
히로시 하시즈메
마사미 에이교
아끼라 마쓰시따
Original Assignee
요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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Application filed by 요시또시 가즈오, 시오노기세이야꾸 가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR910019978A publication Critical patent/KR910019978A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음

Description

스피로 디벤조수베란 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기식(Ⅰ)로 표시되는 화합물 또는 그것의 약제학적으로 허용 가능한 산 부가염
    〔식중 R1은 수소, 알킬, 알케닐, 또는 아랄킬; R2는 수소 또는 알킬; R3및 R4는 각각 동일하거나 상이하며, 수소, 알킬, 알콕시, 또는 할로겐; m은 0또는 1;n은 2~4의 정수임〕
  2. 제1항에 있어서, m이 0인 화합물.
  3. 제1항에 있어서, m이 1인 화합물.
  4. 제1항에 있어서, m은 0이고 n이 3인 화합물
  5. 제1항에 있어서, m은 0이고 n이 2인 화합물
  6. 제1항에 있어서, m은 0이고 n이 4인 화합물
  7. 제4항에 있어서, R1R2및 R3각각이 수소이고 R4는 수소, 알킬, 또는 할로겐인 화합물
  8. 제1항에 있어서, 스피로(디벤조수베란-5,2′-피롤리딘)인 화합물
  9. 제1항에 있어서, 스피로(3-메틸디벤조수베란-5,2′-피롤리딘)인 화합물
  10. 제1항에 있어서, 스피로(3-클로로디벤조수베란-5,2′-피롤리딘)인 화합물
  11. 제1항에 있어서, 약리학적으로 효과적인 양의 화합물과 담체, 희석제 및/또는 부형제를 함께 포함하는 약제학적 조성물.
  12. 제11항에 있어서, 항신경 변성에 효과적인 약제학적 조성물
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910007257A 1990-05-07 1991-05-04 스피로 디벤조수베란 유도체 KR910019978A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2-118126 1990-05-07
JP11812690 1990-05-07

Publications (1)

Publication Number Publication Date
KR910019978A true KR910019978A (ko) 1991-12-19

Family

ID=14728685

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910007257A KR910019978A (ko) 1990-05-07 1991-05-04 스피로 디벤조수베란 유도체

Country Status (10)

Country Link
EP (1) EP0456183B1 (ko)
JP (1) JPH04225953A (ko)
KR (1) KR910019978A (ko)
AT (1) ATE128705T1 (ko)
CA (1) CA2040750A1 (ko)
DE (1) DE69113505T2 (ko)
DK (1) DK0456183T3 (ko)
ES (1) ES2080182T3 (ko)
GR (1) GR3017868T3 (ko)
HU (1) HUT58057A (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538986A (en) * 1993-12-06 1996-07-23 Schering Corporation Tricyclic derivatives, compositions and methods of use
US5760246A (en) * 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
UA73749C2 (en) * 1999-11-01 2005-09-15 Diarylenines
CA2484217A1 (en) * 2002-04-26 2003-11-06 Schering Corporation Muscarinic antagonists
US7101917B2 (en) * 2003-04-14 2006-09-05 Hoffmann-La Roche Inc. Mitochrondrial permeability transition pore affinity labels and modulators
RU2379303C2 (ru) 2003-04-24 2010-01-20 Инсайт Корпорейшн Производные азаспироалканов в качестве ингибиторов металлопротеаз
CA2598878A1 (en) * 2005-02-25 2006-10-05 Irm Llc Spiro-containing compounds and compositions as modulators of steroid hormone nuclear receptors
US9331663B2 (en) 2011-06-07 2016-05-03 Pioneer Corporation Impedance matching device and control method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds

Also Published As

Publication number Publication date
CA2040750A1 (en) 1991-11-08
DE69113505T2 (de) 1996-04-04
EP0456183A2 (en) 1991-11-13
HUT58057A (en) 1992-01-28
EP0456183A3 (en) 1992-04-22
HU911520D0 (en) 1991-11-28
ES2080182T3 (es) 1996-02-01
DE69113505D1 (de) 1995-11-09
DK0456183T3 (da) 1995-11-20
EP0456183B1 (en) 1995-10-04
GR3017868T3 (en) 1996-01-31
ATE128705T1 (de) 1995-10-15
JPH04225953A (ja) 1992-08-14

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