KR890002097A - N-[(2-옥소피롤리딘-1-일)아세틸]피페라진 유도체 및 노인성 치매용 약제 - Google Patents

N-[(2-옥소피롤리딘-1-일)아세틸]피페라진 유도체 및 노인성 치매용 약제 Download PDF

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KR890002097A
KR890002097A KR1019880008858A KR880008858A KR890002097A KR 890002097 A KR890002097 A KR 890002097A KR 1019880008858 A KR1019880008858 A KR 1019880008858A KR 880008858 A KR880008858 A KR 880008858A KR 890002097 A KR890002097 A KR 890002097A
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compound
formula
amino
alkyl
aryl
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KR1019880008858A
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KR900006742B1 (ko
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히로무 마쓰무라
히로시 하시즈메
아끼라 마쓰시따
마사미 에이교
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요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02C—CAPTURE, STORAGE, SEQUESTRATION OR DISPOSAL OF GREENHOUSE GASES [GHG]
    • Y02C20/00—Capture or disposal of greenhouse gases
    • Y02C20/40—Capture or disposal of greenhouse gases of CO2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

N-[(2-옥소피롤리딘-1-일)아세틸]피페라진 유도체 및 노인성 치매용 악제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식(I)의 화합물 또는 그의 약학적으로 허용 가능한 산-부가염 :
    (식중, R은 -SO2R1또는 -CONHR2이고 ; R1은 C1~C|5알킬, C8~C12페닐알케닐, 아미노, 디메틸아미노, 임의 치환된 C8~C12아릴, 또는 N, S, 및 O로 이루어진 군에서 선택된 최소한 하나의 헤테로 원자를 포함하는 5-또는 6-원헤테로사이클기이며 ; R2는 아미노, C1~C5알킬아미노, C1~C5알킬, 또는 임의 치환된 C6~C12)아릴이다).
  2. 제1항에 있어서, 1-[(2-옥소피롤리딘-1-일)아세틸]-4-[(4-플루오로벤젠)설포닐]피페라진인 화합물.
  3. 제1항에 있어서, 1-[(2-옥소피롤리딘-1-일)아세틸]-4-[(2-페닐에테닐)설포닐]피페라진인 화합물.
  4. 제1항에 있어서, 1카르바조일-4-[(4-옥소피로리딘-1-일)아세틸]피페라진인 화합물.
  5. 하기 일반식(I)의 화합물 또는 그의 약학적으로 허용 가능한 산-부가염을 약리학적 유효량으로 함유하는 노인성 치매, 정신병, 또는 건망증 환자의 치료용 약학 조성물:
    (식중, R은 -SO2R1또는 -CONHR2이고 ; R1은 C1~C5알킬, C8~C12페닐알케닐, 아미노, 디메틸아미노, 임의 치환된 C6~C12아릴, 또는 N,S 및 O로 이루어진 군에서 선택된 최소한 하나의 헤테로 원자를 포함하는 5-또는 6-원 헤테로사이클기이며 ; R2는 아미노, C1~C5알킬아미노, , C1~C5알킬, 또는 임의 치환된 C6~C12아릴이다.)
  6. 하기 일반식(II)의 화합물을 하기 일반식(III)의 설포닐 할라이드, 또는 하기 일반식(IV)의 화합물과 반응시킴을 특징으로 하는 하기 일반식(I)의 화합물의 제조방법 :
    (식중, R은 -SO2R1또는 -CONHR2이고 ; R1은 C1~C5알킬, C8~C12페닐알케닐, 아미노, 디메틸아미노, 임의 치환된 C6~C12아릴, 또는 N,S 및 O로 이루어진 군에서 선택된 최소한 하나의 헤테로 원자를 포함하는 5-또는 6-원 헤테로사이클기이며 ; R2는 아미노, C1~C5알킬아미노, C1~C|5알킬, 또는 임의 치환된 C6~C12아릴이고, Hal은 할로겐이다.)
  7. 하기 일반식(II)의 화합물을 하기 일반식(V)의 페닐 할로겐노포르메이트와 반응시켜 하기 일반식(VI)의 화합물을 수득하고, 화합물(VI)를 하기 일반식(VII)의 화합물을 수득하고, 화합물(VI)를 하기 일반식(VII)의 아민과 반응시킴을 특징으로 하는 하기 일반식(I)의 화합물의 제조방법 :
    (식중, R은 -SO2R1또는 -CONHR2이고 ; R1은 C1~C5알킬, C8~C12페닐알케닐, 아미노, 디메틸아미노, 임의 치환된 C6~C12아릴, 또는 N,S 및 O로 이루어진 군에서 선택된 최소한 하나의 헤테로 원자를 포함하는 5-또는 6-원 헤테로사이클기이며 ; R2는 아미노, C1~C5알킬아미노, , C1~C5알킬, 또는 임의 치환된 C6~C12아릴이고 ; Ph는 페닐이고 : X는 할로겐이며, R2는 아미노, C1~C5알킬 아미노, C1~C5알킬, 또는 임의 치환된 C6~C12아릴이다).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008858A 1987-07-15 1988-07-15 N-[(2-옥소피롤리딘-1-일)아세틸]피페라진 유도체 및 노인성 치매용 약제 KR900006742B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP17806487 1987-07-15
JP178064/87 1987-07-15
JP62-178064 1987-07-15

Publications (2)

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KR890002097A true KR890002097A (ko) 1989-04-07
KR900006742B1 KR900006742B1 (ko) 1990-09-20

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US (1) US4904663A (ko)
EP (1) EP0299493B1 (ko)
KR (1) KR900006742B1 (ko)
AT (1) ATE106868T1 (ko)
AU (1) AU608025B2 (ko)
CA (1) CA1322199C (ko)
DE (1) DE3889987T2 (ko)
DK (1) DK393488A (ko)
ES (1) ES2056860T3 (ko)

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IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
US5250528A (en) * 1989-08-02 1993-10-05 Fujisawa Pharmaceutical Co., Ltd. New aminopiperazine derivatives
IT1243702B (it) * 1990-08-08 1994-06-21 Pulitzer Italiana Composti ad attivita' nootropa, procedimento per la loro preparazione e relative composizioni farmaceutiche
WO1998054164A1 (en) * 1997-05-30 1998-12-03 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
EP1054005A4 (en) 1998-02-05 2003-02-05 Takeda Chemical Industries Ltd SULFAMIDE DERIVATIVES, THEIR PRODUCTION PROCESS AND THEIR USE
AUPP818099A0 (en) * 1999-01-14 1999-02-11 Fujisawa Pharmaceutical Co., Ltd. New n-containing heterocyclic compounds
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
JP2004520438A (ja) 2001-03-09 2004-07-08 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド セリンプロテアーゼインヒビターとしてのアミノピロリジンスルホンアミド
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP1889198B1 (en) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatics system
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
EP0005689B1 (fr) * 1978-05-08 1981-03-18 U C B, S.A. Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques
US4372960A (en) * 1980-12-12 1983-02-08 Warner-Lambert Company Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
DE3361609D1 (en) * 1982-03-24 1986-02-06 Prodes Sa New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
CA1250291A (en) * 1984-07-23 1989-02-21 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)-piperazinyl derivatives of 1-pyrrolidin-2-ones
GB8512163D0 (en) * 1985-05-14 1985-06-19 Fujisawa Pharmaceutical Co Oxothiazolidine compound

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DE3889987D1 (de) 1994-07-14
US4904663A (en) 1990-02-27
AU1901388A (en) 1989-01-19
AU608025B2 (en) 1991-03-21
DE3889987T2 (de) 1994-09-15
DK393488D0 (da) 1988-07-14
ES2056860T3 (es) 1994-10-16
ATE106868T1 (de) 1994-06-15
EP0299493B1 (en) 1994-06-08
KR900006742B1 (ko) 1990-09-20
CA1322199C (en) 1993-09-14
DK393488A (da) 1989-01-16
EP0299493A3 (en) 1990-05-23
EP0299493A2 (en) 1989-01-18

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