KR910004664A - 폐 계면활성제 단백질 단편 - Google Patents
폐 계면활성제 단백질 단편 Download PDFInfo
- Publication number
- KR910004664A KR910004664A KR1019900012944A KR900012944A KR910004664A KR 910004664 A KR910004664 A KR 910004664A KR 1019900012944 A KR1019900012944 A KR 1019900012944A KR 900012944 A KR900012944 A KR 900012944A KR 910004664 A KR910004664 A KR 910004664A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- fragments
- amino acid
- surfactant
- fragment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 인지질과 혼합시 계면 활성제 활성을 나타내는 SP-B단백질의 단편 (여기서, 단편은 하나 이상의 말단 아미노산 서열 및 이의 치환, 결실, 복제 및 첨가 유사체를 함유하는 SP-B단백질의 일부이다)을 포함하는 물질의 조성물.
- 제1항에 있어서, SP-B단백질의 단편이 하기 서열로 이루어지는 그룹중에서 선택된 물질의 조성물.h) 이의 치환, 결실 및 첨가 유사체.
- 제1항에 있어서, SP-C, SP-A, SP-C의 단편, SP-A의 단편 및 이들의 혼합물로 이루어지는 그룹 중에서 선택된 화합물 하나 이상과 혼합된 조성물.
- 제1항의 조성물과 하나 이상의 인지질과의 혼합물을 특징으로 하는 물질의 조성물.
- 제4항에 있에, 지질이 합성 인지질, 천연 인지질, 중성 지질, 콜레스테롤, 콜레스테롤 에스테르, 포스파티딜 콜린, 이불포화 포스파티딜콜린, 포스파티딜글리세롤, 디팔미토일 포스파티딜콜린, 포스파티딜이니소틸 및 이들의 혼합물로 이루어지는 그룹 중에서 선택된 물질의 조성물.
- 제4항에 있어서, 제1항의 조성물이 하기 아미노산 서열을 갖는 서열의 혼합물임을 특징으로 하는 물질의 조성물.
- 계면 활성제 물질 부족 또는 계면활성제 물질 이상과 관련된 포자막 질병 또는 다른 증상의 치료를 요하는 환자에게 하나 이상의 SP-B단편 (여기서, 단편은 하나 이상의 말단 아미노산 서열을 함유한다) 및 하나 이상의 지질로 이루어진 유효량의 계면 활성제 조성물을 투여하여 상기 질병 또는 증상을 치료 또는 예방하는 방법.
- 계면 활성제 물질 부족 또는 계면 활성제 물질 이상과 관련된 초지 및 질병 또는 다른 증상의 치료를 요하는 환자에게 1) 하나 이상의 SP-B 단백질의 단편 (여기서, 단편은 하나 이상의 말단 아미노산 서열을 함유하는 SP-B단백질의 일부이다), 2) 하나 이상의 지질 및 3) SP-C및/또는SP-A 또는 이의 작용 단편으로 이루어지는 유효량의 계면 활성제 조성물을 투여하기 상기 질병 또는 증상을 치료 또는 예방하는 방법.
- 폐 약물 전달을 필요로 하는 환자에게 1) 하나 이상의 말단 아미노산 서열을 함유하는 SP-B 단백질의 단편, 2) 하나 이상의 지질 및 3) 적합한 치료제를 포함하는 치료적 유효량의 조성물을 투여함을 특징으로 하는 폐 약물 전달 방법.
- 제9항에 있어서, 지질이 합성 인지질, 천연 인지질, 중성 지질, 콜레스테롤, 콜레스테롤 에스테르, 포스파티딜콜릴, 이불포화 포스파티딜콜린, 포스파티딜글리세롤, 디팔미토일 포스파티딜콜린, 포스파티딜이니소틸 및 이들의 혼합물로 이루어지는 그룹 중에서 선택되는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/397,151 US5238920A (en) | 1989-08-22 | 1989-08-22 | Pulmonary surfactant protein fragments |
US397151 | 1989-08-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR910004664A true KR910004664A (ko) | 1991-03-29 |
Family
ID=23570031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900012944A KR910004664A (ko) | 1989-08-22 | 1990-08-22 | 폐 계면활성제 단백질 단편 |
Country Status (6)
Country | Link |
---|---|
US (2) | US5238920A (ko) |
EP (1) | EP0413957A3 (ko) |
JP (1) | JPH0390033A (ko) |
KR (1) | KR910004664A (ko) |
AU (1) | AU639937B2 (ko) |
CA (1) | CA2022443A1 (ko) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0458167B1 (en) * | 1990-05-21 | 1997-04-23 | Abbott Laboratories | Fatty acid-pulmonary surfactant conjugates |
EP0635028B1 (en) * | 1992-04-10 | 2003-01-22 | Abbott Laboratories | Pulmonary surfactant protein fragments |
US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
ATE220327T1 (de) | 1992-09-29 | 2002-07-15 | Inhale Therapeutic Syst | Pulmonale abgabe von aktiven fragmenten des parathormons |
US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US7448375B2 (en) * | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
WO1995014488A1 (en) * | 1993-11-24 | 1995-06-01 | Ocutech, Inc. | Compositions and methods for the treatment of dry eyes and other ocular disorders |
ES2218543T3 (es) | 1994-03-07 | 2004-11-16 | Nektar Therapeutics | Procedimiento y preparacion para la administracion de insulina por via pulmonar. |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US5780014A (en) * | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
US5658877A (en) * | 1995-05-18 | 1997-08-19 | Wisconsin Alumni Research Foundation | Method to treat endotoxin effects by administration of 33 kilodalton phospholipid binding protein |
US6180596B1 (en) | 1995-05-18 | 2001-01-30 | Wisconsin Alumni Research Foundation | Methods of inhibiting phospholipase A2 and phospholipase A2 stimulator activities |
WO1997029738A1 (en) * | 1996-02-16 | 1997-08-21 | The Administrators Of The Tulane Educational Fund | Methods and compositions for treating eustachian tube dysfunction by inhalation |
US6020307A (en) * | 1997-04-25 | 2000-02-01 | Ony, Inc. | Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C |
US20030203036A1 (en) * | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
GB9703673D0 (en) * | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
US5958902A (en) | 1997-04-16 | 1999-09-28 | Wisconsin Alumni Research Foundation | Method and composition for treating sleep apnea |
US6372720B1 (en) * | 1998-02-05 | 2002-04-16 | Kenneth J. Longmuir | Liposome fusion and delivery vehicle |
US6676930B2 (en) | 1999-11-28 | 2004-01-13 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
US6156294A (en) | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
US7575761B2 (en) * | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
WO2002017878A1 (en) * | 2000-09-01 | 2002-03-07 | Marcus Larsson | Lung surfactant compositions with dynamic swelling behaviour |
GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
US7582284B2 (en) * | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
SE0203591D0 (sv) | 2002-12-04 | 2002-12-04 | Siemens Elema Ab | Förfarande för beredning av ett mediakament och en medicinsk anordning |
EP1663159A4 (en) * | 2003-09-10 | 2010-06-09 | Map Pharmaceuticals Inc | AEROSOL FORMULATIONS FOR THE DELIVERY OF DIHYDROERGOTAMINE TO THE SYSTEMIC CIRCULATION BY PULMONARY INHALATION |
US8124588B2 (en) * | 2003-12-18 | 2012-02-28 | Justus Liebig Universität Giessen | Chimeric plasminogen activators and their pharmaceutical use |
US7582312B2 (en) | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
US7464012B2 (en) * | 2004-12-10 | 2008-12-09 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Simplified process simulator |
US8337815B2 (en) * | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
EP2298349A1 (en) | 2005-01-06 | 2011-03-23 | Discovery Laboratories, Inc. | Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia |
PT103484B (pt) * | 2006-05-19 | 2008-03-31 | Univ Do Minho | Formulação com domínios de ligação hidrófobos e domínios de ligação a hidratos de carbono para aplicações cosméticas nomeadamente para tratamento de fibras queratinosas como o cabelo. |
CA2663795A1 (en) * | 2006-09-19 | 2008-03-27 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations and methods for promoting mucus clearance |
MX2009008582A (es) * | 2007-02-11 | 2009-10-30 | Map Pharmaceuticals Inc | Metodo para la administracion terapeutica de dihidroergotamina para permitir un rapido alivio de la migraña mientras se minimiza el perfil de efectos secundarios. |
US20100284969A1 (en) * | 2007-06-05 | 2010-11-11 | Frank Guarnieri | Methods and Compositions for Delivery of Medicaments to the Lungs |
US9289388B2 (en) | 2008-12-10 | 2016-03-22 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of medicaments to the lungs |
US20110171141A1 (en) * | 2009-06-26 | 2011-07-14 | Kellerman Donald J | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
WO2011035140A1 (en) | 2009-09-18 | 2011-03-24 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of contrast moieties to the lungs |
MX350838B (es) | 2011-02-11 | 2017-09-18 | Grain Proc Corporation * | Composicion de sal. |
WO2013188016A2 (en) | 2012-05-04 | 2013-12-19 | Discovery Laboratories, Inc. | Surfactant therapy for exposure to ionizing radiation |
US20230257446A1 (en) | 2020-01-28 | 2023-08-17 | Chiesi Farmaceutici S.P.A. | Polypeptides having improved properties |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987002037A1 (en) * | 1985-09-26 | 1987-04-09 | Genetics Institute, Inc. | Pulmonary surfactant proteins |
EP0290516A4 (en) * | 1986-10-24 | 1989-11-14 | Jeffrey A Whitsett | PROTEINS RELATED TO SURFACE-EFFECTIVE HYDROPHOBIC LUNG ACTIVE SUBSTANCES. |
JPH01501282A (ja) * | 1986-12-08 | 1989-05-11 | ホイツトセツト,ジエフリー エイ. | 肺胞疎水性界面活性物質関連タンパク質 |
WO1989000167A1 (en) * | 1987-07-01 | 1989-01-12 | Kabigen Ab | Proteins and protein compositions and their use |
JPH01121299A (ja) * | 1987-11-05 | 1989-05-12 | Teijin Ltd | ヒト肺サーファクタントアポ蛋白質 |
US5164369A (en) * | 1988-01-06 | 1992-11-17 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
AU3073789A (en) * | 1988-03-31 | 1989-10-05 | Abbott Laboratories | Drug delivery using pulmonary surfactant to facilitate absorption |
-
1989
- 1989-08-22 US US07/397,151 patent/US5238920A/en not_active Expired - Lifetime
-
1990
- 1990-07-17 EP EP19900113662 patent/EP0413957A3/en not_active Withdrawn
- 1990-08-01 CA CA002022443A patent/CA2022443A1/en not_active Abandoned
- 1990-08-21 JP JP2222315A patent/JPH0390033A/ja active Pending
- 1990-08-21 AU AU61206/90A patent/AU639937B2/en not_active Ceased
- 1990-08-22 KR KR1019900012944A patent/KR910004664A/ko not_active Application Discontinuation
-
1992
- 1992-01-22 US US07/826,323 patent/US5302581A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2022443A1 (en) | 1991-02-23 |
EP0413957A2 (en) | 1991-02-27 |
JPH0390033A (ja) | 1991-04-16 |
EP0413957A3 (en) | 1991-10-16 |
US5238920A (en) | 1993-08-24 |
AU6120690A (en) | 1991-02-28 |
AU639937B2 (en) | 1993-08-12 |
US5302581A (en) | 1994-04-12 |
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