KR910002519A - 효소 전극 및 이의 제조방법 - Google Patents

효소 전극 및 이의 제조방법 Download PDF

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KR910002519A
KR910002519A KR1019890010694A KR890010694A KR910002519A KR 910002519 A KR910002519 A KR 910002519A KR 1019890010694 A KR1019890010694 A KR 1019890010694A KR 890010694 A KR890010694 A KR 890010694A KR 910002519 A KR910002519 A KR 910002519A
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South Korea
Prior art keywords
enzyme
finely divided
carbon
support component
electrode
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KR1019890010694A
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KR0128159B1 (ko
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헨리 뮬렌 윌리암
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캠브리지 라이프 사이언시즈 피엘시
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D5/00—Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/30—Hydrogen technology
    • Y02E60/50—Fuel cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Abstract

내용 없음

Description

효소 전극 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 내지 제9도는 본 발명에 따른 실시예 1 내지 9 각각의 방법에 의해 측정된 여러가지 농도의 글루코오즈에 대한 전극의 전류 출력을 도식한 그래프이다.

Claims (26)

  1. 미분된 백금 금속 또는 산화물 및 하나 이상의 효소를 액체 현탁 매질중에 현탁시키고, 이 현탁액을 지지체 성분의 표면상에 침착시킨후, 침착된 현탁액을 효소의 불활성화 온도 이하의 온도에서 건조시켜 상기의 미분된 백금 그룹 금속 또는 산화물 및 효소(들)를 사실상 균일하고 균질한 피복층으로서 지지체의 표면상에 침착시킴을 특징으로 하여, 미분된 백금 그룹 금속 또는 산화물과 하나 이상의 효소의 사실상 균일한 혼합물을 기본 지지체의 표면상에 전기 전도층으로서 침착시킨 효소 전극[이 전극은, 전극의 효소-함유층이 개개의 효소 기질과 접촉하는 경우, 효소의 활성에 대해 전류적으로 반응한다]을 재조하는 방법.
  2. 제1항에 있어서, 현탁액이 미분된 탄소 또는 흑연 입자를 추가로 함유하는 방법.
  3. 제2항에 있어서, 미분된 백금 그룹 금속 또는 산화물의 입자가 미분된 탄소 또는 흑연 입자의 표면상에 예비 흡착되는 방법.
  4. 제3항에 있어서, 미분된 탄소 또는 흑연 입자가 3 내지 150nm의 입자 크기를 갖고, 여기에 예비 흡착된 미분된 백금 그룹 또는 산화물 1 내지 4nm의 입자 크기를 갖는 방법.
  5. 제1항 내지 4항중 어느 한 항에 있어서, 현탁액이 미분된 백금 그룹 또는 산화물 및 효소(들), 경우에 따라 미분된 탄소 또는 흑연을 혼합시키기 위한 저온 결합제[이 저온 결합제는 효소(들)의 불황성화 온도를 초과하지 않는 온도에서 입자 및 효소를 함께 결합시켜 지지체의 표면상에 응집 효소-함유층을 형성시키는데 유효하다]를 추가로 함유하는 방법.
  6. 제1항 내지 5항중 어느 한항에 있어서, 액체 현탁 매질이 수성 매질인 방법.
  7. 제6항에 있어서, 결합제가 젤라틴 또는 하이드록시에틸셀룰로오즈인 방법.
  8. 제1항 내지 7항중 어느 한 항에 있어서, 현탁액을 인쇄 공정에 의해 지지체 성분의 표면에 적용시키는 방법.
  9. 제8항에 있어서, 현탁액을 스크린 인쇄에 의해 지지체 성분에 적용시키는 방법.
  10. 제1항 내지 9항중 어느 한 항에 있어서, 지지체 성분 자체가 전기 전도성인 방법.
  11. 제10항에 있어서, 전기 전도성 기질이 전기 전도성 탄소 페이퍼 또는 탄소 트랙인 방법.
  12. 제1항 내지 11항중 어느 한 항에 있어서, 미분된 백금 그룹 금속 성분이 미분된 백금 또는 로듐인 방법.
  13. 제1항 내지 12항중 어느 한 항에 있어서, 사용된 효소가 글루코오즈 옥시다아제, 락테이트 옥시다아제 또는 콜레스테롤 옥시다아제인 방법.
  14. 제1항 내지 13항중 어느 한 항에 있어서, 지지체 성분상에 초기에 침착된 미분된 현탁액이 단지 미분된 백금 그룹 금속 또는 산화물, 경우에 따라 미분된 탄소 또는 흑연 및 결합제를 포함하며, 이 미분된 현탁액을 지지체 성분상에 침착시킨 다음, 미분된 입자의 침착된 효소-함유 용액을 사용하여 함침시키고 재건조 시킴으로써, 효소를 상기의 층내로 도입시킴을 특징으로 하는 방법.
  15. 기본 지지체 성분의 표면상에 전기 전도표면층으로서 침착된 미분된 백금 그룹 금속 또는 산화물 및 하나 이상의 효소들의 사실상 효소들의 사실상 균일한 혼합물을 포함하며, 여기서 상기의 층은 미분된 백금 그룹 금속 또는 산화물 및 효소(들)의 입자에 대한 결합제[이 결합제는 효소(들)의 불활성화 온도를 초과하지 않는 온도에서 미분된 백금 그룹 금속 또는 산화물 입자 및 효도(들)를 지지체에 결합된 접착 응집층으로 결합시키기에 유효한 물질을 포함한다]를 추가로 함유함을 특징으로 하는 효소 전극.
  16. 제15항에 있어서, 결합제가 수용성 또는 수분산성인 효소 전극.
  17. 제16항에 있어서, 결합제가 젤라틴 또는 하이드록시에틸셀룰로오즈인 효소 전극.
  18. 제15항에 이써서,효소 자체가 미분된 백금 그룹 또는 산화물에 대한 결합제로서 작용하는 효소 전극.
  19. 제15항 내지 18항중 어느 한항에 있어서, 효소-함유 층이 미분된 탄소 또는 흑연 입자를 추가로 함유하는 효소 전극.
  20. 제19항에 있어서, 백금 그룹 금속 또는 산화물의 미분된 입자가 탄소 또는 흑연 입자의 표면상에 예비흡착 되는 효소 전극.
  21. 제20항에 있어서, 탄소 또는 흑연 입자가 3 내지 150nm의 입자 크기를 갖고, 예비흡착된 백금 그룹 금속 또는 산화물 입자가 1 내지 4nm의 입자 크기를 갖는 효소 전극.
  22. 제15항 내지 21항중 어느 한 항에 있어서, 효소-함유 층이 기본 지지체 성분의 표면상에 인쇄되는 효소 전극.
  23. 제22항에 있어서, 효소-함유층이 지지체 성분의 표면상에 스크린 인쇄되는 효소 전극.
  24. 제15항 내지 23항중 어느 한 항에 있어서, 기본 지지체 성분 자체가 전기 전도성인 효소 전극.
  25. 제24항에 있어서, 지지체 성분이 전기 전도성 탄소 페이퍼 또는 탄소 트랙의 시이트를 포함하느 효소 전극.
  26. 제15항 내지 25항중 어느 한 항에 있어서, 효소-함유층이 효소 글루코오즈 옥시다아제, 락테이트 옥시다아제 또는 콜레스테롤 옥시다아제를 함유하느 효소 전극.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890010694A 1988-07-28 1989-07-28 효소 전극 및 이의 제조방법 KR0128159B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888817997A GB8817997D0 (en) 1988-07-28 1988-07-28 Enzyme electrodes & improvements in manufacture thereof
GB?8817997.3? 1988-07-28
GB8817997.3 1988-07-28

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KR910002519A true KR910002519A (ko) 1991-02-25
KR0128159B1 KR0128159B1 (ko) 1998-04-01

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US (1) US5160418A (ko)
EP (1) EP0352925B1 (ko)
JP (1) JP3056221B2 (ko)
KR (1) KR0128159B1 (ko)
AU (1) AU621913B2 (ko)
CA (1) CA1311522C (ko)
DE (1) DE68920223T2 (ko)
DK (1) DK171603B1 (ko)
FI (1) FI96517C (ko)
GB (2) GB8817997D0 (ko)
HU (1) HU209704B (ko)
IE (1) IE60578B1 (ko)
IL (1) IL90983A (ko)
MX (1) MX170142B (ko)
NO (1) NO300144B1 (ko)
RU (1) RU1836428C (ko)

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IL90983A (en) 1994-01-25
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CA1311522C (en) 1992-12-15
IE892451L (en) 1990-01-28
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GB2221300B (en) 1991-12-18
MX170142B (es) 1993-08-09
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FI893542A0 (fi) 1989-07-24
NO893019L (no) 1990-01-29
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DE68920223T2 (de) 1995-07-13
HUT51326A (en) 1990-04-28
JP3056221B2 (ja) 2000-06-26
EP0352925B1 (en) 1994-12-28
GB8817997D0 (en) 1988-09-01
DK371489A (da) 1990-01-29
NO300144B1 (no) 1997-04-14
RU1836428C (ru) 1993-08-23
FI96517B (fi) 1996-03-29
AU621913B2 (en) 1992-03-26
HU209704B (en) 1994-10-28
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