KR900015717A - 박피복된 모사 캡슐형 약제 - Google Patents

박피복된 모사 캡슐형 약제 Download PDF

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KR900015717A
KR900015717A KR1019900006012A KR900006012A KR900015717A KR 900015717 A KR900015717 A KR 900015717A KR 1019900006012 A KR1019900006012 A KR 1019900006012A KR 900006012 A KR900006012 A KR 900006012A KR 900015717 A KR900015717 A KR 900015717A
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capsule
drug
caplet core
caplet
core
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KR0163188B1 (ko
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비. 파레크 키쇼르
위앤드 데니스씨.
비. 리져 진
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안드레아 엘. 콜비
맥네일-피피씨, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

박피복된 모사 캡슐형 약제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 캡렛 코아의 정면 상단을 도시한 것이고,
제2도는 캡렛 코아의 상단 평면도이며,
제3도는 캡렛 코아의 측면 입면도이다.

Claims (30)

  1. 약제를 포함하는 고형의 캡렛(caplet)코아, 수용성 필름-형성 중합체와 소수성 가스화제의 혼합물을 함유하는 캡렛 코아상의 박피복 조성물, 및 평활한 외부 피막을 함유하고, 박피복 조성물이 캡슐형 약제의 외부 피막을 평활하고 균일하며 실질적으로 기포를 함유하지 않는 외관으로 증진시킴을 특징으로 하는 모사 캡슐형 약제.
  2. 제1항에 있어서, 캡렛 코아의 모양이 약간 굴곡형인 캡슐형 약제.
  3. 제2항에 있어서, 굴곡형이 불록형태이고 캡렛 코아의 종축에 대해 약 1 내지 5°의 가변도를 나타내는 캡슐형 약제.
  4. 모양이 약간 굴곡형인 고상 캡렛 코아를 함유하는 캡슐형 약제.
  5. 제4항에 있어서, 굴곡형인 불록형태이고 캡렛 코아의 종축에 대해 약 1 내지 5°의 가변도를 나타내는 캡슐형 약제.
  6. 약제를 함유하는 고상 캡렛 코아 ; 하이드록시프로필메틸셀룰로즈와 피마자유의 혼합물을 함유하는 캡렛 코아상의 박피복 조성물; 및 평활한 젤라틴성으 ㅣ외부 피막을 함유함을 특징으로 하는 모사 캡슐형 약제.
  7. 제6항에 있어서, 박피복 조성물이 박피복된 캡렛 코아의 총 중량중 약 2 내지 약 8중량%인 약제.
  8. 제6항에 있어서, 박피복 조성물이 박피복된 캡렛 코아의 총 중량중 약 4 내지 약 6중량%인 약제.
  9. 제7항에 있어서, 피마자유가 박피복된 캡렛 코아 총 중량중 약 0.1 내지 1.0중량%인 캡슐형 약제.
  10. 제6항에 있어서, 약제가 아세트아미노펜인 캡슐형 약제.
  11. 제6항에 있어서, 약제가 이부프로펜인 캡슐형 약제.
  12. 제6항에 있어서, 약제가 나프록센인 캡슐형 약제.
  13. 제6항에 있어서, 약제가 로퍼아미드인 캡슐형 약제.
  14. 제6항에 있어서, 약제가 아세트아미노펜, 슈도에페드린, 덱스트로메토르판 및 클로르펜아르이민의 혼합물을 함유하는 캡슐형 약제.
  15. 제6항에 있어서, 약제가 아세트아미노펜과 슈도에페드린의 혼합물을 함유하는 캡슐형 약제.
  16. 제6항에 있어서, 약제가 이부프로펜과 슈도에페드린의 혼합물을 함유하는 캡슐형 약제.
  17. 약간 볼록형으로 굴곡된 고상 캡렛 약제 코아; 하이드록시프로필메틸셀룰로즈와 피마자유의 혼합물이 박피복된 캡렛 코아 총 중량중 약 4중량%인 캡렛 코아의 박피복 조성물; 및 평활한 젤라틴성의 외부 피막을 포함함을 특징으로 하는 모사 캡슐형 약제.
  18. 제17항에 있어서, 약제가 아세트아미노펜, 이부프로펜, 로퍼아미드, 나프록센, 슈도에페드린, 덱스트로메토르판, 클로르펜아르이민, 및 이의 혼합물로 이루어진 그룹중에서 선택되는 캡슐형 약제.
  19. 제17항에 있어서, 약제가 아세트아미노펜인 캡슐형 약제.
  20. 약제와 부형제의 혼합물을 압축시켜 고상 캡렛 코아를 제조하고 ; 수용성 필름 형성-중합체와 소수성 가소화제의 혼합물로 이루어진 박피복 조성물을 언급된 고상 캡렛 코아에 적용시킨 다음; 평활한 외부 피막을 박피복한 캡렛 코아에 적용시켜 외관이 평활하고 균일하묘 기포를 실질적으로 함유하지 않는 외부 피막을 캡슐형 약제에 제공하는 단계를 포함함을 특징으로 하여, 모사 캡슐형 약제를 제조하는 방법.
  21. 제2항에 있어서, 필름 형성-중합체가 하이드록시프로필메틸셀룰로즈이고 가소화제가 파마자유인 방법.
  22. 제20항에 있어서,약제가 아세트아미노펜, 이부프로펜, 로퍼아미드, 나프록센, 슈도에페드린, 덱스트로메토르판, 클로르펜아르이민, 및 이의 혼합물로 이루어진 그룹중에서 선택되는 방법.
  23. 제20항에 있어서, 평활한 외부 피막이 젤라틴을 함유하는 방법.
  24. 제23항에 있어서, 젤라틴 외부 피막이 약 35 내지 55℃의 온도 범위에서 적용되는 방법.
  25. 제23항에 있어서, 약제가 아세트아미노펜이고 젤라틴 외부 피막이 약 40℃의 온도에서 적용되는 방법.
  26. 제23항에 있어서, 젤라틴 외부 피막이 약 40 내지 50℃의 온도 범위에서 적용되는 방법.
  27. 제20항에 있어서, 캡슐형 약제가 조성물 총 중량을 기준으로 하여 박피복 조성물 약 2 내지 약 8%를 함유하는 방법.
  28. 제21항에 있어서, 박피복 조성물이 약 6 내지 약 8중량%의 수성 용액 중에서 를 적용되는 방법.
  29. 제20항에 있어서, 고상 캡렛 코아를 압축하고, 약간 볼록형으로 굴곡된 모양으로 형성시키는 방법.
  30. 제23항에 있어서, 젤란틴 외부 피막을 박피복된 캡슐형 약제를 하나 이상의 젤라틴 용액으로 침지시켜 적용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900006012A 1989-04-28 1990-04-28 서브제피된 유사 캡슐형 약제 KR0163188B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34559989A 1989-04-28 1989-04-28
US345,599 1989-04-28
US345599 1989-04-28

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KR900015717A true KR900015717A (ko) 1990-11-10
KR0163188B1 KR0163188B1 (ko) 1998-12-01

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US (7) US5658589A (ko)
EP (2) EP0395431B1 (ko)
JP (1) JP2939299B2 (ko)
KR (1) KR0163188B1 (ko)
AT (1) ATE142485T1 (ko)
AU (1) AU630949B2 (ko)
CA (1) CA2015478A1 (ko)
DE (1) DE69028433T2 (ko)
DK (1) DK0395431T3 (ko)
ES (1) ES2094142T3 (ko)
GR (1) GR1001024B (ko)
GT (1) GT199000058A (ko)
HK (1) HK17697A (ko)
IE (1) IE76130B1 (ko)
IL (1) IL94217A (ko)
NZ (1) NZ233403A (ko)
PT (1) PT93892B (ko)
ZA (1) ZA903251B (ko)

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US7087242B2 (en) 2006-08-08
AU5457190A (en) 1990-11-01
AU630949B2 (en) 1992-11-12
ATE142485T1 (de) 1996-09-15
JP2939299B2 (ja) 1999-08-25
NZ233403A (en) 1992-09-25
EP0395431A3 (en) 1992-07-01
CA2015478A1 (en) 1990-10-28
EP0711549A2 (en) 1996-05-15
ZA903251B (en) 1991-12-24
PT93892A (pt) 1990-11-20
DE69028433T2 (de) 1997-04-03
IL94217A0 (en) 1991-01-31
US5770225A (en) 1998-06-23
DK0395431T3 (da) 1996-09-30
US5658589A (en) 1997-08-19
GR900100316A (en) 1991-09-27
PT93892B (pt) 1996-10-31
US20020031546A1 (en) 2002-03-14
EP0395431B1 (en) 1996-09-11
HK17697A (en) 1997-02-13
IE901551L (en) 1990-10-28
JPH02304021A (ja) 1990-12-17
US6326026B1 (en) 2001-12-04
US6214380B1 (en) 2001-04-10
KR0163188B1 (ko) 1998-12-01
IL94217A (en) 1994-11-28
GT199000058A (es) 1992-02-22
GR1001024B (el) 1993-03-31
EP0711549A3 (ko) 1996-05-22
DE69028433D1 (de) 1996-10-17
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IE76130B1 (en) 1997-10-08
US5916592A (en) 1999-06-29
US6120801A (en) 2000-09-19
EP0395431A2 (en) 1990-10-31

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