KR900007242B1 - 2-아자스피로[4.(3+n)]-3-카복실산 유도체의 제조방법 - Google Patents

2-아자스피로[4.(3+n)]-3-카복실산 유도체의 제조방법 Download PDF

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Publication number
KR900007242B1
KR900007242B1 KR1019830001217A KR830001217A KR900007242B1 KR 900007242 B1 KR900007242 B1 KR 900007242B1 KR 1019830001217 A KR1019830001217 A KR 1019830001217A KR 830001217 A KR830001217 A KR 830001217A KR 900007242 B1 KR900007242 B1 KR 900007242B1
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KR
South Korea
Prior art keywords
compound
formula
alkyl
hydrogen
iii
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KR1019830001217A
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English (en)
Korean (ko)
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KR840004070A (ko
Inventor
테쯔 폴커
우르바하 한스예르그
벡커 라인하르트
Original Assignee
훽스트 아크티엔게젤샤프트
하인리히 벡커, 베른하르트 벡크
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Publication of KR840004070A publication Critical patent/KR840004070A/ko
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Publication of KR900007242B1 publication Critical patent/KR900007242B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
KR1019830001217A 1982-03-27 1983-03-25 2-아자스피로[4.(3+n)]-3-카복실산 유도체의 제조방법 Expired KR900007242B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3211397.8 1982-03-27
DE19823211397 DE3211397A1 (de) 1982-03-27 1982-03-27 Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Publications (2)

Publication Number Publication Date
KR840004070A KR840004070A (ko) 1984-10-06
KR900007242B1 true KR900007242B1 (ko) 1990-10-06

Family

ID=6159524

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001217A Expired KR900007242B1 (ko) 1982-03-27 1983-03-25 2-아자스피로[4.(3+n)]-3-카복실산 유도체의 제조방법

Country Status (20)

Country Link
US (1) US4558064A (enExample)
EP (1) EP0090341B1 (enExample)
JP (1) JPS58177968A (enExample)
KR (1) KR900007242B1 (enExample)
AT (1) ATE28565T1 (enExample)
AU (1) AU565400B2 (enExample)
CA (1) CA1197857A (enExample)
DE (2) DE3211397A1 (enExample)
DK (1) DK164789C (enExample)
ES (2) ES520987A0 (enExample)
FI (1) FI80877C (enExample)
GR (1) GR78496B (enExample)
HU (2) HU190875B (enExample)
IE (1) IE54291B1 (enExample)
MA (1) MA19758A1 (enExample)
NO (1) NO162284C (enExample)
NZ (1) NZ203699A (enExample)
PH (1) PH19270A (enExample)
PT (1) PT76450B (enExample)
ZA (1) ZA832139B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3300774A1 (de) * 1983-01-12 1984-07-12 Hoechst Ag, 6230 Frankfurt Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
US4876359A (en) * 1986-10-07 1989-10-24 Ss Pharmaceutical Co., Ltd. Novel gamma-butyrolactone derivatives
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
BG62359B1 (bg) * 1995-07-13 1999-09-30 Anormed N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DK0796855T3 (da) 1996-03-20 2002-05-27 Hoechst Ag Hæmmere af knogleresorption og vitronectin-receptorantagonister
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
SE518184C2 (sv) 2000-03-31 2002-09-03 Perstorp Flooring Ab Golvbeläggningsmaterial innefattande skivformiga golvelement vilka sammanfogas med hjälp av sammankopplingsorgan
BRPI0409428A (pt) * 2003-04-15 2006-04-18 Warner Lambert Co derivados de prolina bicìclicos [c]-fundidos e a sua utilização para tratar estados artrìticos
WO2004092132A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
EP0050800B2 (en) * 1980-10-23 1995-06-07 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3218540A1 (de) * 1982-05-17 1983-11-24 Hoechst Ag, 6230 Frankfurt Spiro-2-aza-alkan-3-carbonitrile, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
PT76450B (de) 1986-01-27
HUT34730A (en) 1985-04-28
FI831009L (fi) 1983-09-28
EP0090341B1 (de) 1987-07-29
NO162284B (no) 1989-08-28
ES8401941A1 (es) 1984-01-01
FI80877C (fi) 1990-08-10
DK138283A (da) 1983-09-28
IE830662L (en) 1983-09-27
MA19758A1 (fr) 1983-10-01
JPS58177968A (ja) 1983-10-18
IE54291B1 (en) 1989-08-16
NO162284C (no) 1989-12-06
ES520987A0 (es) 1984-01-01
ES521655A0 (es) 1984-01-16
KR840004070A (ko) 1984-10-06
PH19270A (en) 1986-02-21
HU190875B (en) 1986-11-28
ATE28565T1 (de) 1987-08-15
CA1197857A (en) 1985-12-10
EP0090341A2 (de) 1983-10-05
ZA832139B (en) 1983-12-28
US4558064A (en) 1985-12-10
DE3211397A1 (de) 1983-11-10
NZ203699A (en) 1985-07-12
HU190486B (en) 1986-09-29
FI831009A0 (fi) 1983-03-24
NO831095L (no) 1983-09-28
FI80877B (fi) 1990-04-30
DK138283D0 (da) 1983-03-25
DE3372707D1 (en) 1987-09-03
PT76450A (de) 1983-04-01
EP0090341A3 (en) 1984-09-12
DK164789B (da) 1992-08-17
JPH0342271B2 (enExample) 1991-06-26
AU1287183A (en) 1983-09-29
AU565400B2 (en) 1987-09-17
DK164789C (da) 1993-01-04
ES8402272A1 (es) 1984-01-16
GR78496B (enExample) 1984-09-27

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