KR900003128A - 아미노-치환된 가교결합 아자비사이클릭 퀴놀론 카복실산 및 에스테르 - Google Patents

아미노-치환된 가교결합 아자비사이클릭 퀴놀론 카복실산 및 에스테르 Download PDF

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Publication number
KR900003128A
KR900003128A KR1019890011932A KR890011932A KR900003128A KR 900003128 A KR900003128 A KR 900003128A KR 1019890011932 A KR1019890011932 A KR 1019890011932A KR 890011932 A KR890011932 A KR 890011932A KR 900003128 A KR900003128 A KR 900003128A
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KR
South Korea
Prior art keywords
hydrogen
compound
azabicyclic
esters
amino
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KR1019890011932A
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English (en)
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KR910007238B1 (ko
Inventor
폭스 클레인맨 에드워드
Original Assignee
알렌 제이.스피겔
화이자 인코포레이티드
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Publication of KR900003128A publication Critical patent/KR900003128A/ko
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Publication of KR910007238B1 publication Critical patent/KR910007238B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)

Abstract

내용 없음

Description

아미노-치환된 가교결합 아자비사이클릭 퀴놀론 카복실산 및 에스테르
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(I)의 화합물 또는 그의 약학적으로 허용되는 염.
    상기식에서, R1은 수소, C1-C6알킬 또는 약학적으로 허용되는 양이온이고; Y는 사이클로프로필, 에틸 또는 p-플루오로페닐이며, X는 수소 또는 플루오로이거나, 또는 X와 Y는 함께
    또는그룹을 형성하며; R2는(여기에서, R3는 수소 또는 C1-C4알킬기이다)이다.
  2. 제1항에 있어서,
    R2가
    또는인 화합물.
  3. 제1항 또는 2항에 있어서, R3가 수소인 화합물.
  4. 제1항 또는 2항에 있어서, Y가 사이클로프로필인 화합물.
  5. 제1항 또는 2항에 있어서, X가 수소인 화합물.
  6. 항균 효과량의 제1항 내지 5항중의 어느 한 항에 따르는 화합물 및 약학적으로 허용되는 담체를 함유하는 항균 약학 조성물.
  7. 세균 감염증의 치료를 필요로 하는 포유동물에게 항균효과량의 제1항 내지 6항 중 어느 한 항의 화합물 또는 조성물을 투여함을 포함하는, 포유동물의 세균감염증을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890011932A 1988-08-23 1989-08-22 아미노-치환된 가교결합 아자비사이클릭 퀴놀론 카복실산 및 에스테르 KR910007238B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1988/002908 WO1990002123A1 (en) 1988-08-23 1988-08-23 Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US88/02908 1988-08-23
USPCT/US88/2908 1988-08-23

Publications (2)

Publication Number Publication Date
KR900003128A true KR900003128A (ko) 1990-03-23
KR910007238B1 KR910007238B1 (ko) 1991-09-24

Family

ID=22208868

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890011932A KR910007238B1 (ko) 1988-08-23 1989-08-22 아미노-치환된 가교결합 아자비사이클릭 퀴놀론 카복실산 및 에스테르

Country Status (18)

Country Link
EP (1) EP0356193B1 (ko)
JP (1) JPH0637495B2 (ko)
KR (1) KR910007238B1 (ko)
AT (1) ATE101609T1 (ko)
AU (1) AU605434B2 (ko)
CA (1) CA1334413C (ko)
DE (1) DE68913099T2 (ko)
DK (1) DK411989A (ko)
ES (1) ES2062017T3 (ko)
FI (1) FI97386C (ko)
IE (1) IE61370B1 (ko)
IL (1) IL91331A0 (ko)
MY (1) MY107389A (ko)
NO (1) NO901764L (ko)
NZ (1) NZ230374A (ko)
PT (1) PT91498B (ko)
WO (1) WO1990002123A1 (ko)
ZA (1) ZA896395B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04315332A (ja) * 1991-04-15 1992-11-06 Hitachi Ltd 誤り訂正装置
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227055A1 (de) * 1982-07-20 1984-01-26 Hoechst Ag, 6230 Frankfurt Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
IN166416B (ko) * 1985-09-18 1990-05-05 Pfizer
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
US4803205A (en) * 1987-08-07 1989-02-07 Warner-Lambert Company Quinolones as antibacterial agents

Also Published As

Publication number Publication date
EP0356193A3 (en) 1990-12-27
FI901994A0 (fi) 1990-04-20
CA1334413C (en) 1995-02-14
IE892683L (en) 1990-02-23
IE61370B1 (en) 1994-11-02
EP0356193A2 (en) 1990-02-28
IL91331A0 (en) 1990-03-19
AU605434B2 (en) 1991-01-10
PT91498B (pt) 1995-05-04
EP0356193B1 (en) 1994-02-16
JPH0291072A (ja) 1990-03-30
NZ230374A (en) 1991-07-26
DK411989D0 (da) 1989-08-22
ZA896395B (en) 1991-04-24
AU4011489A (en) 1990-05-03
MY107389A (en) 1995-11-30
NO901764D0 (no) 1990-04-20
DE68913099D1 (de) 1994-03-24
NO901764L (no) 1990-06-08
JPH0637495B2 (ja) 1994-05-18
ES2062017T3 (es) 1994-12-16
FI97386C (fi) 1996-12-10
DE68913099T2 (de) 1994-05-26
WO1990002123A1 (en) 1990-03-08
FI97386B (fi) 1996-08-30
DK411989A (da) 1990-02-24
KR910007238B1 (ko) 1991-09-24
PT91498A (pt) 1990-03-08
ATE101609T1 (de) 1994-03-15

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