KR900001214B1 - 1-아릴옥시-2,3,4,5-테트라하이드로-3-벤즈아제핀의 제조방법 - Google Patents

1-아릴옥시-2,3,4,5-테트라하이드로-3-벤즈아제핀의 제조방법 Download PDF

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Publication number
KR900001214B1
KR900001214B1 KR1019830002597A KR830002597A KR900001214B1 KR 900001214 B1 KR900001214 B1 KR 900001214B1 KR 1019830002597 A KR1019830002597 A KR 1019830002597A KR 830002597 A KR830002597 A KR 830002597A KR 900001214 B1 KR900001214 B1 KR 900001214B1
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KR
South Korea
Prior art keywords
compound
tetrahydro
formula
benzazine
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830002597A
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English (en)
Korean (ko)
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KR840005103A (ko
Inventor
챨레스 에플란드 리챠드
토마스 클레인 조세프
데이비스 라리
Original Assignee
훽스트-로우쎌 파마슈티컬 인코포레이티드
마크 이.로가트
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Application filed by 훽스트-로우쎌 파마슈티컬 인코포레이티드, 마크 이.로가트 filed Critical 훽스트-로우쎌 파마슈티컬 인코포레이티드
Publication of KR840005103A publication Critical patent/KR840005103A/ko
Application granted granted Critical
Publication of KR900001214B1 publication Critical patent/KR900001214B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1019830002597A 1982-06-14 1983-06-11 1-아릴옥시-2,3,4,5-테트라하이드로-3-벤즈아제핀의 제조방법 Expired KR900001214B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US387,916 1982-06-14
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof
US389,916 1989-08-07

Publications (2)

Publication Number Publication Date
KR840005103A KR840005103A (ko) 1984-11-03
KR900001214B1 true KR900001214B1 (ko) 1990-02-28

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002597A Expired KR900001214B1 (ko) 1982-06-14 1983-06-11 1-아릴옥시-2,3,4,5-테트라하이드로-3-벤즈아제핀의 제조방법

Country Status (17)

Country Link
US (1) US4988690A (https=)
EP (1) EP0096838B1 (https=)
JP (1) JPS595165A (https=)
KR (1) KR900001214B1 (https=)
AT (1) ATE26263T1 (https=)
AU (1) AU570920B2 (https=)
CA (1) CA1214460A (https=)
DE (1) DE3370621D1 (https=)
DK (1) DK270983A (https=)
ES (1) ES523191A0 (https=)
FI (1) FI78473C (https=)
GR (1) GR78291B (https=)
HU (1) HU190902B (https=)
IE (1) IE55404B1 (https=)
IL (1) IL68964A (https=)
PT (1) PT76864B (https=)
ZA (1) ZA834309B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
CA1327795C (en) * 1987-08-14 1994-03-15 Jules Freedman Antidepressants which are aryloxy inadanamines
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
AU2002228725A1 (en) * 2000-11-30 2002-06-11 Advanced Research And Technology Institute, Inc. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CN1805938B (zh) * 2003-06-17 2010-06-16 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
HUE028976T2 (en) * 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
SI1838677T1 (sl) 2004-12-21 2010-01-29 Arena Pharm Inc Kristalne oblike (R)-8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepin hidroklorida
SG158168A1 (en) 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
EP2471779A1 (en) 2006-04-03 2012-07-04 Arena Pharmaceuticals, Inc. Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8299241B2 (en) * 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
CA2685861A1 (en) 2007-05-10 2008-11-20 Amr Technology, Inc. Aryloxy-and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
CN102015591B (zh) 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
KR20140091458A (ko) 2010-09-01 2014-07-21 아레나 파마슈티칼스, 인크. 신장 손상을 갖는 개체에 대한 로카세린의 투여
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
ES8503666A1 (es) 1985-03-01
EP0096838A1 (en) 1983-12-28
CA1214460A (en) 1986-11-25
PT76864B (en) 1986-02-27
FI78473B (fi) 1989-04-28
IL68964A0 (en) 1983-10-31
JPS595165A (ja) 1984-01-12
AU570920B2 (en) 1988-03-31
PT76864A (en) 1983-07-01
ZA834309B (en) 1984-03-28
FI832092L (fi) 1983-12-15
DK270983A (da) 1983-12-15
JPH0365342B2 (https=) 1991-10-11
FI832092A0 (fi) 1983-06-10
EP0096838B1 (en) 1987-04-01
IE55404B1 (en) 1990-09-12
ES523191A0 (es) 1985-03-01
KR840005103A (ko) 1984-11-03
FI78473C (fi) 1989-08-10
ATE26263T1 (de) 1987-04-15
IE831384L (en) 1983-12-14
AU1576483A (en) 1983-12-22
US4988690A (en) 1991-01-29
DK270983D0 (da) 1983-06-13
IL68964A (en) 1988-03-31
HU190902B (en) 1986-12-28
GR78291B (https=) 1984-09-26
DE3370621D1 (en) 1987-05-07

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Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19830611

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Patent event code: PA02012R01D

Patent event date: 19870925

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19830611

Comment text: Patent Application

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19900129

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19900528

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee