KR890700021A - 인지질 조성물 - Google Patents

인지질 조성물

Info

Publication number
KR890700021A
KR890700021A KR1019880700887A KR880700887A KR890700021A KR 890700021 A KR890700021 A KR 890700021A KR 1019880700887 A KR1019880700887 A KR 1019880700887A KR 880700887 A KR880700887 A KR 880700887A KR 890700021 A KR890700021 A KR 890700021A
Authority
KR
South Korea
Prior art keywords
composition
lipozoom
liposomes
sphingomyelin
bioactive agent
Prior art date
Application number
KR1019880700887A
Other languages
English (en)
Other versions
KR900007831B1 (ko
Inventor
파울 에이 트렘블레이
로버트 엘 수디스
죤 제이 케아른스
Original Assignee
원본미기재
더 리포조옴 캄파니, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 더 리포조옴 캄파니, 인코포레이티드 filed Critical 원본미기재
Publication of KR890700021A publication Critical patent/KR890700021A/ko
Application granted granted Critical
Publication of KR900007831B1 publication Critical patent/KR900007831B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

내용 없음

Description

인지질 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 약 97% 중량% 또는 그 이상의 포스파티딜콜린, 그리고 약 3중량% 또는 그 이하 내지 최소한 약 0.5중량%의 스핑고미엘린을 포함하고 그리고 실질적으로 리조포스파티딜콜린은 없는 제약학적 제품 품질의 지질 조성물.
  2. 제1항에 있어서, 약 3중량% 내지 약 1.5중량%(UV a 205nm)의 스핑고미엘린을 가지는 조성물.
  3. 제2항에 따른 조성물을 포함하는 리포조옴.
  4. 제3항에 있어서, 최소한 하나의 생체활성제를 포함하는 리포조옴.
  5. 제2항에 있어서, 최소한 약 2%의 스핑고미엘린을 포함하는 조성물.
  6. 제5항의 조성물을 포함하는 리포조옴.
  7. 제6항에 있어서, 최소한 하나의 생체 활성제를 추가로 포함하는 리포조옴.
  8. 제1항의 조성물을 포함하는 리포조옴.
  9. 제8항에 있어서, 최소한 하나의 생체 활성제를 추가로 포함하는 리포조옴.
  10. 제약학적 제품 품질의 조성물의 제조방법에 있어서, 전술한 조성물이 약 97중량% 또는 그 이상의 포스파티딜콜린 및 약 3중량% 또는 그이하 내지 최소한 약 0.5중량%의 스핑고메엘린을 포함하고 그리고 리조포스파티딜콜린은 전혀 없으며, 전술한 방법이 헥산-에탄올-물 혼합물의 경사로서 용출하여 액체 크로마토그래피 실리카 칼럼으로 조성물을 단리하는 단계를 포함하는 제약학적 제품 품질의 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880700887A 1986-11-28 1987-11-25 인지질 조성물 KR900007831B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US93591986A 1986-11-28 1986-11-28
US935,919 1986-11-28
US93856386A 1986-12-05 1986-12-05
US938,563 1986-12-05
US11957287A 1987-11-17 1987-11-17
US119,572 1987-11-17
PCT/US1987/003131 WO1988003797A1 (en) 1986-11-28 1987-11-25 Phospholipid composition

Publications (2)

Publication Number Publication Date
KR890700021A true KR890700021A (ko) 1989-03-02
KR900007831B1 KR900007831B1 (ko) 1990-10-20

Family

ID=27382333

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880700887A KR900007831B1 (ko) 1986-11-28 1987-11-25 인지질 조성물

Country Status (10)

Country Link
US (2) US5429823A (ko)
EP (1) EP0293465B1 (ko)
JP (1) JP2517094B2 (ko)
KR (1) KR900007831B1 (ko)
AU (1) AU599456B2 (ko)
CA (1) CA1308025C (ko)
DE (1) DE3777640D1 (ko)
NZ (1) NZ222716A (ko)
SG (1) SG76892G (ko)
WO (1) WO1988003797A1 (ko)

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DE4107152C2 (de) * 1991-03-06 1994-03-24 Gregor Cevc Präparate zur nichtinvasiven Verabreichung von Antidiabetica
DE4107153A1 (de) * 1991-03-06 1992-09-10 Gregor Cevc Praeparat zur wirkstoffapplikation in kleinsttroepfchenform
JPH09502700A (ja) * 1993-04-02 1997-03-18 ザ リポソーム カンパニー、インコーポレーテッド リポソームの製造方法
US20020048596A1 (en) * 1994-12-30 2002-04-25 Gregor Cevc Preparation for the transport of an active substance across barriers
US6210707B1 (en) * 1996-11-12 2001-04-03 The Regents Of The University Of California Methods of forming protein-linked lipidic microparticles, and compositions thereof
US6071533A (en) * 1996-11-12 2000-06-06 The Regents Of The University Of California Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery
DE19981729D2 (de) * 1998-08-29 2001-08-09 Ghyczy Miklos Pharmazeutisches und/oder diätetisches Produkt
CA2309633C (en) * 1998-10-23 2010-12-14 Idea Innovative Dermale Applikationen Gmbh Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates
EP1031347B1 (en) 1999-01-27 2002-04-17 Idea Ag Transnasal transport/immunisation with highly adaptable carriers
DE69901377T2 (de) 1999-01-27 2003-01-02 Idea Ag Nichtinvasive Impfung durch die Haut
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
ES2332869T3 (es) * 1999-11-17 2010-02-15 Boston Scientific Limited Dispositivos microfabricados para la entrega de moleculas en fluidos portadores.
US20040105881A1 (en) * 2002-10-11 2004-06-03 Gregor Cevc Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
CA2584475A1 (en) * 2004-11-12 2006-05-18 Idea Ag Extended surface aggregates in the treatment of skin conditions
CN100500676C (zh) * 2006-04-17 2009-06-17 江南大学 一种不含溶血磷脂的高纯大豆磷脂酰胆碱的制备方法
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
US20130066064A1 (en) * 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
MY161428A (en) 2012-09-12 2017-04-14 Sime Darby Malaysia Berhad Extracting Lecithin From Palm Agro-Waste
US9353137B2 (en) * 2014-02-07 2016-05-31 Ghassem Amoabediny Method for separation and purification of phosphatidylcholine employing magnetic nanoparticles and compositions so produced
EP3478296A4 (en) 2016-06-29 2020-03-25 Machavert Pharmaceuticals LLC PHOSOPHOLIPID COMPOSITIONS
CN108101938B (zh) * 2017-11-17 2021-05-11 扬子江药业集团有限公司 一种高纯度多烯磷脂酰胆碱的制备方法

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US2390528A (en) * 1940-05-13 1945-12-11 Pittsburgh Plate Glass Co Extraction of phosphatides, free fatty acids, and the like from glyceride oils
US2727046A (en) * 1951-12-17 1955-12-13 Charles R Scholfield Purification of phosphatides
US2801255A (en) * 1955-06-17 1957-07-30 Charles R Scholfield Method of purifying phosphatidyl ethanolamine
GB933814A (en) * 1959-05-12 1963-08-14 Unilever Ltd Improvements in or relating to the purification of phosphatides
FR6256M (ko) * 1967-01-26 1968-08-19
US3869482A (en) * 1972-07-31 1975-03-04 Etapharm Chem Pharm Lab G M B Method of producing highly purified phosphatides
DE2718797C3 (de) * 1977-04-27 1987-06-19 A. Nattermann & Cie GmbH, 5000 Köln Verfahren zur Gewinnung fließfähiger ölhaltiger gereinigter Phosphatidylcholin
CH624011A5 (ko) * 1977-08-05 1981-07-15 Battelle Memorial Institute
JPS595263B2 (ja) * 1977-10-25 1984-02-03 キユーピー株式会社 卵黄燐脂質の製造法
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US4157404A (en) * 1978-07-28 1979-06-05 Asahi Kasei Kogyo Kabushiki Kaisha Process for obtaining yolk lecithin from raw egg yolk
IT1111367B (it) * 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
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Also Published As

Publication number Publication date
AU599456B2 (en) 1990-07-19
AU1156788A (en) 1988-06-16
KR900007831B1 (ko) 1990-10-20
SG76892G (en) 1992-10-02
JP2517094B2 (ja) 1996-07-24
DE3777640D1 (ko) 1992-04-23
US5429823A (en) 1995-07-04
US5783210A (en) 1998-07-21
WO1988003797A1 (en) 1988-06-02
CA1308025C (en) 1992-09-29
EP0293465A1 (en) 1988-12-07
NZ222716A (en) 1990-08-28
EP0293465A4 (en) 1988-11-28
JPH01501479A (ja) 1989-05-25
EP0293465B1 (en) 1992-03-18

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