KR890002756B1 - 알릴아민 mao 억제제의 제조 방법 - Google Patents

알릴아민 mao 억제제의 제조 방법 Download PDF

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Publication number
KR890002756B1
KR890002756B1 KR8202435A KR820002435A KR890002756B1 KR 890002756 B1 KR890002756 B1 KR 890002756B1 KR 8202435 A KR8202435 A KR 8202435A KR 820002435 A KR820002435 A KR 820002435A KR 890002756 B1 KR890002756 B1 KR 890002756B1
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KR
South Korea
Prior art keywords
phenyl
hydrogen
fluorine
formula
compound
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Expired
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KR8202435A
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English (en)
Korean (ko)
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KR830010044A (ko
Inventor
베이 필리뻬
Original Assignee
삐에르 쥴리앙
메렐 토라우드 엘 캄파니
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Publication of KR890002756B1 publication Critical patent/KR890002756B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Treatment Of Sludge (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
KR8202435A 1981-06-01 1982-05-31 알릴아민 mao 억제제의 제조 방법 Expired KR890002756B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US268555 1981-06-01
US06/268,555 US4454158A (en) 1981-06-01 1981-06-01 Allyl amine MAO inhibitors
US268.555 1982-06-01

Publications (2)

Publication Number Publication Date
KR830010044A KR830010044A (ko) 1983-12-24
KR890002756B1 true KR890002756B1 (ko) 1989-07-27

Family

ID=23023513

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202435A Expired KR890002756B1 (ko) 1981-06-01 1982-05-31 알릴아민 mao 억제제의 제조 방법

Country Status (18)

Country Link
US (1) US4454158A (enExample)
EP (1) EP0067105B1 (enExample)
JP (1) JPS5823649A (enExample)
KR (1) KR890002756B1 (enExample)
AT (1) ATE29875T1 (enExample)
AU (2) AU550607B2 (enExample)
CA (2) CA1187500A (enExample)
DE (1) DE3277371D1 (enExample)
DK (1) DK244282A (enExample)
ES (4) ES8402810A1 (enExample)
GB (2) GB2100255B (enExample)
GR (1) GR78033B (enExample)
IE (1) IE53456B1 (enExample)
IL (2) IL65808A (enExample)
MX (1) MX9202950A (enExample)
NO (1) NO152837C (enExample)
NZ (1) NZ200644A (enExample)
ZA (1) ZA823633B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699928A (en) * 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
US4703058A (en) * 1984-12-31 1987-10-27 Merrell Dow Pharmaceuticals Inc. β-methylene furanethanamines and use as anti-hypertensive agents
NZ214697A (en) * 1984-12-31 1988-10-28 Merrell Dow Pharma B-methylene-2- and 3-furanethanamine and pharmaceutical compositions
NZ214698A (en) * 1984-12-31 1988-08-30 Merrell Dow Pharma Thiophene derivatives and pharmaceutical compositions containing such
JPH0660132B2 (ja) * 1985-12-05 1994-08-10 メレルダウフア−マス−テイカルズ インコ−ポレ−テツド 非芳香族フルオロアリルアミンｍａｏ阻害剤
US4650907A (en) * 1985-12-05 1987-03-17 Merrell Dow Pharmaceuticals Inc. Nonaromatic fluoroallylamine MAO inhibitors
US4822812A (en) * 1987-05-21 1989-04-18 Merrell Dow Pharmaceuticals Inc. β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
AU612655B2 (en) * 1987-06-16 1991-07-18 Merrell Dow Pharmaceuticals Inc. (e)-2-(p-fluorophenethyl)-3-fluoroallylamine
AU618076B2 (en) * 1988-02-25 1991-12-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyloxidase
US5252608A (en) * 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4943593A (en) * 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5059714A (en) * 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5182297A (en) * 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4965288A (en) * 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) * 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4981868A (en) * 1989-07-25 1991-01-01 Merrell Dow Pharmaceutical Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins
PT814789E (pt) * 1995-03-02 2003-09-30 Scherer Technologies Inc R P Composicoes farmaceuticas compreendendo inibidores de monoamina-oxidase b
EP2004166A2 (en) * 2006-03-31 2008-12-24 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
EP2046794A1 (de) * 2006-07-13 2009-04-15 Basf Se Fungizide azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
WO2009055002A1 (en) * 2007-10-24 2009-04-30 La Jolla Pharmaceutical Company Combined inhibitors of cyclooxygenase and semicarbazide-sensitive amine oxidase (ssao) (vascular adhesion protein, vap-1)
JP2011504485A (ja) 2007-11-21 2011-02-10 ファーマクシス リミテッド Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途
PT2844637T (pt) 2012-05-02 2018-04-17 Boehringer Ingelheim Int Inibidores de 3-haloalilamina substituídos de ssao e as suas utilizações
WO2015087094A1 (en) * 2013-12-10 2015-06-18 Semmelweis Egyetem New arylalkenylpropargylamine derivatives exhibiting neuroprotective action for the treatment of neurodegenerative diseases
WO2017136870A1 (en) 2016-02-12 2017-08-17 Pharmaxis Ltd. Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
MX2021001347A (es) 2018-08-03 2021-04-13 Pharmaxis Ltd Inhibidores derivados de haloalilamina sulfona de lisil oxidasas y sus usos.
US12578335B2 (en) 2020-02-05 2026-03-17 Syntara Limited Bioprobes for lysyl oxidases and uses thereof
US12233056B2 (en) 2022-04-06 2025-02-25 Syntara Limited Lysyl oxidase inhibitors for treating myeloid malignancies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2343038A1 (de) * 1973-08-25 1975-03-06 Hoechst Ag 2,3-diaryl-3-halogenallylamine und verfahren zu ihrer herstellung
SE7809127L (sv) * 1978-08-30 1980-03-01 Claesson Alf Allenaminer

Also Published As

Publication number Publication date
EP0067105B1 (en) 1987-09-23
IL65808A (en) 1986-12-31
ATE29875T1 (de) 1987-10-15
US4454158B1 (enExample) 1992-12-22
DE3277371D1 (en) 1987-10-29
IE53456B1 (en) 1988-11-23
GB2100255A (en) 1982-12-22
US4454158A (en) 1984-06-12
GB2100255B (en) 1985-10-23
CA1187500A (en) 1985-05-21
ES523874A0 (es) 1985-04-16
GB2152039B (en) 1986-04-30
IL75829A0 (en) 1985-11-29
ES512699A0 (es) 1984-03-01
EP0067105A2 (en) 1982-12-15
MX9202950A (es) 1992-07-01
AU576281B2 (en) 1988-08-18
ES8507461A1 (es) 1985-10-01
KR830010044A (ko) 1983-12-24
AU5180586A (en) 1986-06-12
JPH0422898B2 (enExample) 1992-04-20
GB2152039A (en) 1985-07-31
IE821246L (en) 1982-12-01
NO152837C (no) 1985-11-27
EP0067105A3 (en) 1984-02-22
ES8402810A1 (es) 1984-03-01
AU550607B2 (en) 1986-03-27
CA1204759A (en) 1986-05-20
DK244282A (da) 1982-12-02
ES8503639A1 (es) 1985-04-16
ZA823633B (en) 1983-03-30
ES523875A0 (es) 1985-04-16
NO821799L (no) 1982-12-02
ES523873A0 (es) 1985-10-01
JPS5823649A (ja) 1983-02-12
GR78033B (enExample) 1984-09-26
NO152837B (no) 1985-08-19
GB8428858D0 (en) 1984-12-27
ES8503638A1 (es) 1985-04-16
IL65808A0 (en) 1982-08-31
NZ200644A (en) 1986-06-11
AU8423882A (en) 1983-02-03

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