ES523874A0 - Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos. - Google Patents

Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.

Info

Publication number
ES523874A0
ES523874A0 ES523874A ES523874A ES523874A0 ES 523874 A0 ES523874 A0 ES 523874A0 ES 523874 A ES523874 A ES 523874A ES 523874 A ES523874 A ES 523874A ES 523874 A0 ES523874 A0 ES 523874A0
Authority
ES
Spain
Prior art keywords
sub
integer
hydrogen
formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES523874A
Other languages
English (en)
Other versions
ES8503638A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of ES8503638A1 publication Critical patent/ES8503638A1/es
Publication of ES523874A0 publication Critical patent/ES523874A0/es
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483Monocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486Polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Treatment Of Sludge (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ES523874A 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos. Granted ES523874A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/268,555 US4454158A (en) 1981-06-01 1981-06-01 Allyl amine MAO inhibitors

Publications (2)

Publication Number Publication Date
ES8503638A1 ES8503638A1 (es) 1985-04-16
ES523874A0 true ES523874A0 (es) 1985-04-16

Family

ID=23023513

Family Applications (4)

Application Number Title Priority Date Filing Date
ES512699A Granted ES512699A0 (es) 1981-06-01 1982-05-31 Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.
ES523875A Granted ES523875A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699
ES523873A Expired ES8507461A1 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.
ES523874A Granted ES523874A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES512699A Granted ES512699A0 (es) 1981-06-01 1982-05-31 Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.
ES523875A Granted ES523875A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699
ES523873A Expired ES8507461A1 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.

Country Status (18)

Country Link
US (1) US4454158A (es)
EP (1) EP0067105B1 (es)
JP (1) JPS5823649A (es)
KR (1) KR890002756B1 (es)
AT (1) ATE29875T1 (es)
AU (2) AU550607B2 (es)
CA (2) CA1187500A (es)
DE (1) DE3277371D1 (es)
DK (1) DK244282A (es)
ES (4) ES512699A0 (es)
GB (2) GB2100255B (es)
GR (1) GR78033B (es)
IE (1) IE53456B1 (es)
IL (2) IL65808A (es)
MX (1) MX9202950A (es)
NO (1) NO152837C (es)
NZ (1) NZ200644A (es)
ZA (1) ZA823633B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699928A (en) * 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
NZ214697A (en) * 1984-12-31 1988-10-28 Merrell Dow Pharma B-methylene-2- and 3-furanethanamine and pharmaceutical compositions
US4703058A (en) * 1984-12-31 1987-10-27 Merrell Dow Pharmaceuticals Inc. β-methylene furanethanamines and use as anti-hypertensive agents
NZ214698A (en) * 1984-12-31 1988-08-30 Merrell Dow Pharma Thiophene derivatives and pharmaceutical compositions containing such
US4650907A (en) * 1985-12-05 1987-03-17 Merrell Dow Pharmaceuticals Inc. Nonaromatic fluoroallylamine MAO inhibitors
ATE71933T1 (de) * 1985-12-05 1992-02-15 Merrell Dow Pharma Nichtaromatische fluoralkylamin-mao-inhibitoren.
US4822812A (en) * 1987-05-21 1989-04-18 Merrell Dow Pharmaceuticals Inc. β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
CA1335897C (en) * 1987-06-16 1995-06-13 Ian A. Mcdonald (e)-2-(p-fluorophenethyl)-3-fluoroallylamine
US5059714A (en) * 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5182297A (en) * 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
NZ228068A (en) * 1988-02-25 1991-11-26 Merrell Dow Pharma Brominated or chlorinated allylamines and their pharmaceutical compositions
US5252608A (en) * 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4943593A (en) * 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4965288A (en) * 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) * 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4981868A (en) * 1989-07-25 1991-01-01 Merrell Dow Pharmaceutical Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins
TR199700878T1 (xx) * 1995-03-02 1998-01-21 R.P. Scherer Limited Monamin oksidaz B inhibit�rleri i�eren farmakotik kompozisyonlar.
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
BRPI0713944A2 (pt) * 2006-07-13 2012-12-04 Basf Se compostos, processo para preparar compostos, composição, semente e, processo para combater fungos nocivos fitopatogênicos
WO2009055002A1 (en) * 2007-10-24 2009-04-30 La Jolla Pharmaceutical Company Combined inhibitors of cyclooxygenase and semicarbazide-sensitive amine oxidase (ssao) (vascular adhesion protein, vap-1)
CN101917845A (zh) 2007-11-21 2010-12-15 法马克西斯制药公司 Ssao/vap-1的卤代烯丙胺抑制剂及其用途
RS57086B1 (sr) 2012-05-02 2018-06-29 Boehringer Ingelheim Int Supstituisani 3-haloalilamin inhibitori ssao i njihova primena
WO2015087094A1 (en) * 2013-12-10 2015-06-18 Semmelweis Egyetem New arylalkenylpropargylamine derivatives exhibiting neuroprotective action for the treatment of neurodegenerative diseases
AR115906A1 (es) 2018-08-03 2021-03-10 Pharmaxis Ltd Derivados de haloalilamina sulfona como inhibidores de lisil oxidasas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2343038A1 (de) * 1973-08-25 1975-03-06 Hoechst Ag 2,3-diaryl-3-halogenallylamine und verfahren zu ihrer herstellung
SE7809127L (sv) * 1978-08-30 1980-03-01 Claesson Alf Allenaminer

Also Published As

Publication number Publication date
ES8503638A1 (es) 1985-04-16
MX9202950A (es) 1992-07-01
DK244282A (da) 1982-12-02
US4454158B1 (es) 1992-12-22
NO152837B (no) 1985-08-19
ES8503639A1 (es) 1985-04-16
IL65808A (en) 1986-12-31
EP0067105B1 (en) 1987-09-23
NO821799L (no) 1982-12-02
KR830010044A (ko) 1983-12-24
GB8428858D0 (en) 1984-12-27
GB2100255B (en) 1985-10-23
NO152837C (no) 1985-11-27
JPH0422898B2 (es) 1992-04-20
US4454158A (en) 1984-06-12
EP0067105A3 (en) 1984-02-22
IL65808A0 (en) 1982-08-31
IE53456B1 (en) 1988-11-23
IE821246L (en) 1982-12-01
GB2152039B (en) 1986-04-30
AU550607B2 (en) 1986-03-27
AU8423882A (en) 1983-02-03
ES523875A0 (es) 1985-04-16
CA1204759A (en) 1986-05-20
CA1187500A (en) 1985-05-21
KR890002756B1 (ko) 1989-07-27
DE3277371D1 (en) 1987-10-29
ES523873A0 (es) 1985-10-01
GB2152039A (en) 1985-07-31
EP0067105A2 (en) 1982-12-15
JPS5823649A (ja) 1983-02-12
ES8402810A1 (es) 1984-03-01
AU5180586A (en) 1986-06-12
GB2100255A (en) 1982-12-22
ZA823633B (en) 1983-03-30
AU576281B2 (en) 1988-08-18
NZ200644A (en) 1986-06-11
GR78033B (es) 1984-09-26
ATE29875T1 (de) 1987-10-15
ES8507461A1 (es) 1985-10-01
IL75829A0 (en) 1985-11-29
ES512699A0 (es) 1984-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020304