ES8503639A1 - Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699 - Google Patents

Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699

Info

Publication number
ES8503639A1
ES8503639A1 ES523875A ES523875A ES8503639A1 ES 8503639 A1 ES8503639 A1 ES 8503639A1 ES 523875 A ES523875 A ES 523875A ES 523875 A ES523875 A ES 523875A ES 8503639 A1 ES8503639 A1 ES 8503639A1
Authority
ES
Spain
Prior art keywords
integer
hydrogen
formula
phenyl
mao inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523875A
Other languages
English (en)
Other versions
ES523875A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of ES523875A0 publication Critical patent/ES523875A0/es
Publication of ES8503639A1 publication Critical patent/ES8503639A1/es
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Treatment Of Sludge (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS INHIBIDORES DE ALIL AMINA MONOAMINA OXIDASA.COMPRENDE: A) TRATAR A UN COMPUESTO DE FORMULA (III) O (IV), CON BENZALDEHIDO, EN PRESENCIA DE UN ALCOHOL INFERIOR (ETANOL), PARA FORMAR LA BASE DE SCHIFF; B) TRATAR A LA BASE DE SCHIFF CON TETRAFLUORUROBORATO DE TRIETILOXONIO, PARA OBTENER UN COMPUESTO INTERMEDIO; Y C) HIDROLIZAR AL COMPUESTO INTERMEDIO, PARA PRODUCIR COMPUESTOS INHIBIDORES DE ALIL AMINA MONOAMINA OXIDASA DE FORMULA (I) O (II). SIENDO: R, FENILO, 3,4-METILENO-DIOXOFENILO, 1- O 2-NAFTILO Y OTROS; R1, H, ALQUILO DE C 1 A 8 Y OTROS; X E Y INDEPENDIENTES ENTRE SI, SIGNIFICAN, H, F, CL O BR; A, UN RADICAL DE FORMULA (V); R2, H, METILO O ETILO; Y M Y N INDEPENDIENTES ENTRE SI SON NUMEROS ENTEROS DE 0 A 4, SIENDO MBN H 4.SE UTILIZAN PARA EL TRATAMIENTO DE DESORDENES PSIQUIATRICOS (DEPRESIONES).
ES523875A 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699 Expired ES8503639A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/268,555 US4454158A (en) 1981-06-01 1981-06-01 Allyl amine MAO inhibitors

Publications (2)

Publication Number Publication Date
ES523875A0 ES523875A0 (es) 1985-04-16
ES8503639A1 true ES8503639A1 (es) 1985-04-16

Family

ID=23023513

Family Applications (4)

Application Number Title Priority Date Filing Date
ES512699A Granted ES512699A0 (es) 1981-06-01 1982-05-31 Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.
ES523873A Expired ES8507461A1 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.
ES523874A Granted ES523874A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.
ES523875A Expired ES8503639A1 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES512699A Granted ES512699A0 (es) 1981-06-01 1982-05-31 Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.
ES523873A Expired ES8507461A1 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.
ES523874A Granted ES523874A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.

Country Status (18)

Country Link
US (1) US4454158A (es)
EP (1) EP0067105B1 (es)
JP (1) JPS5823649A (es)
KR (1) KR890002756B1 (es)
AT (1) ATE29875T1 (es)
AU (2) AU550607B2 (es)
CA (2) CA1187500A (es)
DE (1) DE3277371D1 (es)
DK (1) DK244282A (es)
ES (4) ES512699A0 (es)
GB (2) GB2100255B (es)
GR (1) GR78033B (es)
IE (1) IE53456B1 (es)
IL (2) IL65808A (es)
MX (1) MX9202950A (es)
NO (1) NO152837C (es)
NZ (1) NZ200644A (es)
ZA (1) ZA823633B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699928A (en) * 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
NZ214698A (en) * 1984-12-31 1988-08-30 Merrell Dow Pharma Thiophene derivatives and pharmaceutical compositions containing such
NZ214697A (en) * 1984-12-31 1988-10-28 Merrell Dow Pharma B-methylene-2- and 3-furanethanamine and pharmaceutical compositions
US4703058A (en) * 1984-12-31 1987-10-27 Merrell Dow Pharmaceuticals Inc. β-methylene furanethanamines and use as anti-hypertensive agents
US4650907A (en) * 1985-12-05 1987-03-17 Merrell Dow Pharmaceuticals Inc. Nonaromatic fluoroallylamine MAO inhibitors
ATE71933T1 (de) * 1985-12-05 1992-02-15 Merrell Dow Pharma Nichtaromatische fluoralkylamin-mao-inhibitoren.
US4822812A (en) * 1987-05-21 1989-04-18 Merrell Dow Pharmaceuticals Inc. β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
AU612655B2 (en) * 1987-06-16 1991-07-18 Merrell Dow Pharmaceuticals Inc. (e)-2-(p-fluorophenethyl)-3-fluoroallylamine
CA1338647C (en) * 1988-02-25 1996-10-15 Michael G. Palfreyman Inhibitors of lysyl oxidase
US4943593A (en) * 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5182297A (en) * 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5059714A (en) * 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5252608A (en) * 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4965288A (en) * 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) * 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4981868A (en) * 1989-07-25 1991-01-01 Merrell Dow Pharmaceutical Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins
SK284383B6 (sk) * 1995-03-02 2005-02-04 R.P. Scherer Limited Farmaceutický prostriedok na orálne podávanie obsahujúci inhibítory monoaminoxidázy B a jeho použitie
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
CN101511839A (zh) * 2006-07-13 2009-08-19 巴斯夫欧洲公司 杀真菌的唑并嘧啶、其制备方法及其在防治有害真菌中的用途以及包含它们的组合物
WO2009055002A1 (en) * 2007-10-24 2009-04-30 La Jolla Pharmaceutical Company Combined inhibitors of cyclooxygenase and semicarbazide-sensitive amine oxidase (ssao) (vascular adhesion protein, vap-1)
US8426587B2 (en) 2007-11-21 2013-04-23 Pharmaxis Ltd. Haloallylamine inhibitors of SSAO/VAP-1 and uses therefor
SG10201707020TA (en) 2012-05-02 2017-10-30 Boehringer Ingelheim Int Substituted 3-haloallylamine inhibitors of ssao and uses thereof
WO2015087094A1 (en) * 2013-12-10 2015-06-18 Semmelweis Egyetem New arylalkenylpropargylamine derivatives exhibiting neuroprotective action for the treatment of neurodegenerative diseases
CN112533897B (zh) 2018-08-03 2023-07-14 法玛西斯有限公司 赖氨酰氧化酶的卤代烯丙胺砜衍生抑制剂及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2343038A1 (de) * 1973-08-25 1975-03-06 Hoechst Ag 2,3-diaryl-3-halogenallylamine und verfahren zu ihrer herstellung
SE7809127L (sv) * 1978-08-30 1980-03-01 Claesson Alf Allenaminer

Also Published As

Publication number Publication date
EP0067105B1 (en) 1987-09-23
NO821799L (no) 1982-12-02
JPS5823649A (ja) 1983-02-12
KR890002756B1 (ko) 1989-07-27
CA1204759A (en) 1986-05-20
US4454158B1 (es) 1992-12-22
ES523875A0 (es) 1985-04-16
NZ200644A (en) 1986-06-11
ES8402810A1 (es) 1984-03-01
AU8423882A (en) 1983-02-03
DE3277371D1 (en) 1987-10-29
NO152837B (no) 1985-08-19
ES8503638A1 (es) 1985-04-16
GB2152039A (en) 1985-07-31
ATE29875T1 (de) 1987-10-15
GB2100255A (en) 1982-12-22
AU5180586A (en) 1986-06-12
ZA823633B (en) 1983-03-30
JPH0422898B2 (es) 1992-04-20
GB8428858D0 (en) 1984-12-27
GR78033B (es) 1984-09-26
AU576281B2 (en) 1988-08-18
GB2100255B (en) 1985-10-23
IE821246L (en) 1982-12-01
GB2152039B (en) 1986-04-30
DK244282A (da) 1982-12-02
IL65808A0 (en) 1982-08-31
NO152837C (no) 1985-11-27
IL65808A (en) 1986-12-31
CA1187500A (en) 1985-05-21
ES523873A0 (es) 1985-10-01
KR830010044A (ko) 1983-12-24
US4454158A (en) 1984-06-12
ES8507461A1 (es) 1985-10-01
IL75829A0 (en) 1985-11-29
ES512699A0 (es) 1984-03-01
AU550607B2 (en) 1986-03-27
EP0067105A3 (en) 1984-02-22
EP0067105A2 (en) 1982-12-15
IE53456B1 (en) 1988-11-23
MX9202950A (es) 1992-07-01
ES523874A0 (es) 1985-04-16

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FD1A Patent lapsed

Effective date: 20020304