ES8503638A1 - Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos. - Google Patents

Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.

Info

Publication number
ES8503638A1
ES8503638A1 ES523874A ES523874A ES8503638A1 ES 8503638 A1 ES8503638 A1 ES 8503638A1 ES 523874 A ES523874 A ES 523874A ES 523874 A ES523874 A ES 523874A ES 8503638 A1 ES8503638 A1 ES 8503638A1
Authority
ES
Spain
Prior art keywords
integer
hydrogen
formula
phenyl
mao inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523874A
Other languages
English (en)
Other versions
ES523874A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merrell Toraude et Cie
Original Assignee
Merrell Toraude et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie
Publication of ES8503638A1 publication Critical patent/ES8503638A1/es
Publication of ES523874A0 publication Critical patent/ES523874A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Treatment Of Sludge (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS INHIBIDORES DE ALIL AMINA MONOAMINA OXIDASA, PARA LA COMPOSICION DE PRODUCTOS FARMACEUTICOS, DE FORMULA GENERAL (I) O FORMULA GENERAL (II).CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA GENERAL (III) O FORMULA GENERAL (IV), EN LAS QUE RD ES HIDROGENO O (C1-C4) ALQUILO.DE APLICACION EN PSIQUIATRIA PARA EL TRATAMIENTO DE LA DEPRESION.
ES523874A 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos. Granted ES523874A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/268,555 US4454158A (en) 1981-06-01 1981-06-01 Allyl amine MAO inhibitors

Publications (2)

Publication Number Publication Date
ES8503638A1 true ES8503638A1 (es) 1985-04-16
ES523874A0 ES523874A0 (es) 1985-04-16

Family

ID=23023513

Family Applications (4)

Application Number Title Priority Date Filing Date
ES512699A Granted ES512699A0 (es) 1981-06-01 1982-05-31 Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.
ES523874A Granted ES523874A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.
ES523875A Expired ES8503639A1 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699
ES523873A Granted ES523873A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES512699A Granted ES512699A0 (es) 1981-06-01 1982-05-31 Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES523875A Expired ES8503639A1 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699
ES523873A Granted ES523873A0 (es) 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.

Country Status (18)

Country Link
US (1) US4454158A (es)
EP (1) EP0067105B1 (es)
JP (1) JPS5823649A (es)
KR (1) KR890002756B1 (es)
AT (1) ATE29875T1 (es)
AU (2) AU550607B2 (es)
CA (2) CA1187500A (es)
DE (1) DE3277371D1 (es)
DK (1) DK244282A (es)
ES (4) ES512699A0 (es)
GB (2) GB2100255B (es)
GR (1) GR78033B (es)
IE (1) IE53456B1 (es)
IL (2) IL65808A (es)
MX (1) MX9202950A (es)
NO (1) NO152837C (es)
NZ (1) NZ200644A (es)
ZA (1) ZA823633B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699928A (en) * 1984-07-13 1987-10-13 Merrell Dow Pharmaceuticals Inc. Fluoroallylamine derivatives
NZ214697A (en) * 1984-12-31 1988-10-28 Merrell Dow Pharma B-methylene-2- and 3-furanethanamine and pharmaceutical compositions
US4703058A (en) * 1984-12-31 1987-10-27 Merrell Dow Pharmaceuticals Inc. β-methylene furanethanamines and use as anti-hypertensive agents
NZ214698A (en) * 1984-12-31 1988-08-30 Merrell Dow Pharma Thiophene derivatives and pharmaceutical compositions containing such
US4650907A (en) * 1985-12-05 1987-03-17 Merrell Dow Pharmaceuticals Inc. Nonaromatic fluoroallylamine MAO inhibitors
ES2033233T3 (es) * 1985-12-05 1993-03-16 Merrell Dow Pharmaceuticals Inc. Un procedimiento para preparar una fluoralilamina.
US4822812A (en) * 1987-05-21 1989-04-18 Merrell Dow Pharmaceuticals Inc. β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
AU612655B2 (en) * 1987-06-16 1991-07-18 Merrell Dow Pharmaceuticals Inc. (e)-2-(p-fluorophenethyl)-3-fluoroallylamine
US4943593A (en) * 1988-02-25 1990-07-24 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
FI890827A (fi) * 1988-02-25 1989-08-26 Merrell Dow Pharma Lysyloxidas-inhibitorer.
US5252608A (en) * 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4965288A (en) * 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5059714A (en) * 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5182297A (en) * 1988-02-25 1993-01-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) * 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4981868A (en) * 1989-07-25 1991-01-01 Merrell Dow Pharmaceutical Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins
ATE241346T1 (de) * 1995-03-02 2003-06-15 Scherer Technologies Inc R P Arzneimittel enthaltend monoaminooxidase-b-hemmer
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
EP2046794A1 (de) * 2006-07-13 2009-04-15 Basf Se Fungizide azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
WO2009055002A1 (en) * 2007-10-24 2009-04-30 La Jolla Pharmaceutical Company Combined inhibitors of cyclooxygenase and semicarbazide-sensitive amine oxidase (ssao) (vascular adhesion protein, vap-1)
NZ585528A (en) 2007-11-21 2012-08-31 Pharmaxis Ltd Haloallylamine inhibitors of ssao/vap-1 and uses therefor
CN107266332B (zh) 2012-05-02 2020-07-24 勃林格殷格翰国际有限公司 Ssao的取代的3-卤代烯丙基胺抑制剂及其用途
WO2015087094A1 (en) * 2013-12-10 2015-06-18 Semmelweis Egyetem New arylalkenylpropargylamine derivatives exhibiting neuroprotective action for the treatment of neurodegenerative diseases
AU2019315330A1 (en) 2018-08-03 2021-01-21 Pharmaxis Ltd. Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2343038A1 (de) * 1973-08-25 1975-03-06 Hoechst Ag 2,3-diaryl-3-halogenallylamine und verfahren zu ihrer herstellung
SE7809127L (sv) * 1978-08-30 1980-03-01 Claesson Alf Allenaminer

Also Published As

Publication number Publication date
EP0067105A3 (en) 1984-02-22
ES523875A0 (es) 1985-04-16
CA1187500A (en) 1985-05-21
DE3277371D1 (en) 1987-10-29
ES8503639A1 (es) 1985-04-16
ES8507461A1 (es) 1985-10-01
US4454158A (en) 1984-06-12
KR890002756B1 (ko) 1989-07-27
GR78033B (es) 1984-09-26
MX9202950A (es) 1992-07-01
GB2152039A (en) 1985-07-31
JPS5823649A (ja) 1983-02-12
CA1204759A (en) 1986-05-20
AU576281B2 (en) 1988-08-18
NZ200644A (en) 1986-06-11
GB2100255B (en) 1985-10-23
GB2152039B (en) 1986-04-30
KR830010044A (ko) 1983-12-24
JPH0422898B2 (es) 1992-04-20
NO821799L (no) 1982-12-02
EP0067105A2 (en) 1982-12-15
IL65808A0 (en) 1982-08-31
DK244282A (da) 1982-12-02
US4454158B1 (es) 1992-12-22
GB8428858D0 (en) 1984-12-27
ES8402810A1 (es) 1984-03-01
IL65808A (en) 1986-12-31
ES512699A0 (es) 1984-03-01
AU550607B2 (en) 1986-03-27
NO152837B (no) 1985-08-19
EP0067105B1 (en) 1987-09-23
ZA823633B (en) 1983-03-30
IL75829A0 (en) 1985-11-29
AU5180586A (en) 1986-06-12
ES523873A0 (es) 1985-10-01
IE53456B1 (en) 1988-11-23
AU8423882A (en) 1983-02-03
IE821246L (en) 1982-12-01
NO152837C (no) 1985-11-27
ES523874A0 (es) 1985-04-16
GB2100255A (en) 1982-12-22
ATE29875T1 (de) 1987-10-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020304