KR890000864B1 - 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진- 2-카르복실산, 그 유도체 및 제조방법 - Google Patents

6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진- 2-카르복실산, 그 유도체 및 제조방법 Download PDF

Info

Publication number
KR890000864B1
KR890000864B1 KR1019830005376A KR830005376A KR890000864B1 KR 890000864 B1 KR890000864 B1 KR 890000864B1 KR 1019830005376 A KR1019830005376 A KR 1019830005376A KR 830005376 A KR830005376 A KR 830005376A KR 890000864 B1 KR890000864 B1 KR 890000864B1
Authority
KR
South Korea
Prior art keywords
fluoro
dihydro
carboxylic acid
quinolizine
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830005376A
Other languages
English (en)
Korean (ko)
Other versions
KR840006659A (ko
Inventor
마아크 스턴 리챠드
Original Assignee
라이커 레보러토리스 인코포레이티드
로날드 올리버 바우콜
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 라이커 레보러토리스 인코포레이티드, 로날드 올리버 바우콜 filed Critical 라이커 레보러토리스 인코포레이티드
Publication of KR840006659A publication Critical patent/KR840006659A/ko
Priority to KR1019890000674A priority Critical patent/KR890000863B1/ko
Application granted granted Critical
Publication of KR890000864B1 publication Critical patent/KR890000864B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1019830005376A 1982-11-12 1983-11-12 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진- 2-카르복실산, 그 유도체 및 제조방법 Expired KR890000864B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890000674A KR890000863B1 (ko) 1982-11-12 1989-01-21 퀴날딘 유도체

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/441,245 US4472405A (en) 1982-11-12 1982-11-12 Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives
US441245 1982-11-12
US441,245 1982-11-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019890000674A Division KR890000863B1 (ko) 1982-11-12 1989-01-21 퀴날딘 유도체

Publications (2)

Publication Number Publication Date
KR840006659A KR840006659A (ko) 1984-12-01
KR890000864B1 true KR890000864B1 (ko) 1989-04-11

Family

ID=23752110

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830005376A Expired KR890000864B1 (ko) 1982-11-12 1983-11-12 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진- 2-카르복실산, 그 유도체 및 제조방법

Country Status (22)

Country Link
US (1) US4472405A (https=)
EP (1) EP0109284B1 (https=)
JP (1) JPH0826017B2 (https=)
KR (1) KR890000864B1 (https=)
AT (1) ATE39926T1 (https=)
AU (1) AU568319B2 (https=)
CA (2) CA1254568A (https=)
CS (1) CS390391A3 (https=)
DE (1) DE3378912D1 (https=)
EG (1) EG16492A (https=)
ES (1) ES8504727A1 (https=)
FI (1) FI73213C (https=)
GR (1) GR79402B (https=)
IE (1) IE56232B1 (https=)
IL (1) IL70198A (https=)
IN (1) IN161391B (https=)
MX (1) MX7314E (https=)
NO (1) NO160782C (https=)
NZ (1) NZ206233A (https=)
OA (1) OA07586A (https=)
PT (1) PT77649B (https=)
ZA (1) ZA838436B (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3519926A1 (de) * 1985-06-04 1986-12-04 Bayer Ag Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel
CA1302413C (en) * 1986-01-22 1992-06-02 Bruce E. Williams Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo- 1h,5h-benzo[ij]quinolizine-2-carboxylic acid
US4898945A (en) * 1986-01-22 1990-02-06 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
GB9827865D0 (en) * 1998-12-18 1999-02-10 Woodcock Fiona Medicament
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
ES2806256T3 (es) 2010-10-12 2021-02-17 Bayer Ip Gmbh Productos masticables blandos no basados en almidón
NZ708741A (en) 2012-12-19 2019-11-29 Bayer Animal Health Gmbh Tablets with improved acceptance and good storage stability
MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
US12350281B2 (en) 2019-05-24 2025-07-08 Dechra Veterinary Products, Llc Long-acting injectable formulations and use thereof
CA3150301A1 (en) * 2019-09-06 2021-03-11 Stacy ROSS GRANULAR VETERINARY COMPOSITIONS OF PLEASANT TASTE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA728444B (en) * 1971-12-30 1973-10-31 Riker Laboratories Inc Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
JPS5655388A (en) 1979-10-11 1981-05-15 Otsuka Pharmaceut Co Ltd Benzo ij quinolidine-2-carboxylic acid derivative, and its preparation
US4301289A (en) * 1980-02-19 1981-11-17 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法

Also Published As

Publication number Publication date
FI73213C (fi) 1987-09-10
NO160782B (no) 1989-02-20
CA1254568A (en) 1989-05-23
IN161391B (https=) 1987-11-28
FI834147L (fi) 1984-05-13
NO160782C (no) 1989-05-31
IL70198A (en) 1988-11-15
EG16492A (en) 1994-11-30
FI73213B (fi) 1987-05-29
EP0109284B1 (en) 1989-01-11
IL70198A0 (en) 1984-02-29
AU2118183A (en) 1984-05-17
NO834093L (no) 1984-05-14
DE3378912D1 (de) 1989-02-16
ES527163A0 (es) 1985-05-01
ES8504727A1 (es) 1985-05-01
IE832639L (en) 1984-05-12
US4472405A (en) 1984-09-18
OA07586A (fr) 1985-03-31
GR79402B (https=) 1984-10-22
JPS59112969A (ja) 1984-06-29
PT77649A (en) 1983-12-01
PT77649B (en) 1986-03-19
MX7314E (es) 1988-05-11
NZ206233A (en) 1986-10-08
EP0109284A1 (en) 1984-05-23
KR840006659A (ko) 1984-12-01
ATE39926T1 (de) 1989-01-15
FI834147A0 (fi) 1983-11-11
JPH0826017B2 (ja) 1996-03-13
IE56232B1 (en) 1991-05-22
ZA838436B (en) 1985-06-26
CS390391A3 (en) 1992-09-16
AU568319B2 (en) 1987-12-24
CA1280755C (en) 1991-02-26

Similar Documents

Publication Publication Date Title
KR890000864B1 (ko) 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진- 2-카르복실산, 그 유도체 및 제조방법
US4067993A (en) Antimicrobial 2-nitro-3-phenylbenzofurancarboxylic acids
EP0107201A2 (en) Phenyl-substituted tricyclic antibacterial agents
US4404207A (en) Antimicrobial 8-substituted benzo [IJ]quinolizines
JPH0145468B2 (https=)
US4472407A (en) Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu
US4472406A (en) Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
US4051247A (en) Method of using 7-hydroxy-benzo[ij]quinolizine-2-carboxylic acid derivatives
KR890000863B1 (ko) 퀴날딘 유도체
US4380543A (en) Antimicrobial 8-cyano-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids
US4001243A (en) Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof
EP0079162B1 (en) Derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine
US4691016A (en) Intermediates for the preparation of 8,9-dihalobenzo[ij]quinolizine carboxylic acids
US4524148A (en) Antimicrobial 8,9-dihalobenzo[ij]quinolizine carboxylic acids
US4585868A (en) Precursors of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
US4014877A (en) Substituted benzo[ij]quinolizine-2-carboxylic acids and derivatives thereof
US4556713A (en) 6-Fluoro-5-nitroquinaldine
US4568750A (en) Precursors of 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu
US4348521A (en) Substituted pyridoquinoxaline-6-carboxylic acids and derivatives thereof
JPS6270370A (ja) キノロンカルボン酸誘導体およびその製造方法
US4456606A (en) Substituted naphtho[ij]quinolizines
US4499270A (en) Substituted pyridoquinoxaline-6-carboxylic acids and derivatives thereof
US4567269A (en) Intermediates for the preparation of 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids
US3985753A (en) 7-Hydroxy-benzo[ij]quinolizine-2-carboxylic acids and derivatives thereof
NO883545L (no) Diethyl-2-(n-(6-fluor-5-methyl-1,2,3,4-tetrahydrokinaldinyl))-methylenmalonat for anvendelse som utgangsmateriale ved fremstilling av terapeutisk aktive forbindelser.

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

FPAY Annual fee payment

Payment date: 19980403

Year of fee payment: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19990412

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19990412

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000