KR880007073A - 의 약 품 - Google Patents
의 약 품 Download PDFInfo
- Publication number
- KR880007073A KR880007073A KR870014390A KR870014390A KR880007073A KR 880007073 A KR880007073 A KR 880007073A KR 870014390 A KR870014390 A KR 870014390A KR 870014390 A KR870014390 A KR 870014390A KR 880007073 A KR880007073 A KR 880007073A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- active ingredient
- carbazole
- tetrahydro
- per unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003814 drug Substances 0.000 title claims 8
- 239000004480 active ingredient Substances 0.000 claims 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- -1 2-methyl-1H-imidazol-1-yl Chemical group 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- NSNHWTBQMQIDCF-UHFFFAOYSA-N dihydrate;hydrochloride Chemical compound O.O.Cl NSNHWTBQMQIDCF-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- 239000012458 free base Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- LXBGSDVWAMZHDD-UHFFFAOYSA-N 2-methyl-1h-imidazole Chemical compound CC1=NC=CN1 LXBGSDVWAMZHDD-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- KZCSGONCLLTHRA-UHFFFAOYSA-N carbazol-4-one Chemical compound C1=CC=CC2=C3C(=O)C=CC=C3N=C21 KZCSGONCLLTHRA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- 230000035790 physiological processes and functions Effects 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 1
- FELGMEQIXOGIFQ-UHFFFAOYSA-N Ondansetron Chemical compound CC1=NC=CN1CC1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-UHFFFAOYSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Emergency Protection Circuit Devices (AREA)
- Connection Of Batteries Or Terminals (AREA)
- Electrotherapy Devices (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868630071A GB8630071D0 (en) | 1986-12-17 | 1986-12-17 | Medicaments |
| GB8630071 | 1986-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR880007073A true KR880007073A (ko) | 1988-08-26 |
Family
ID=10609112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR870014390A Ceased KR880007073A (ko) | 1986-12-17 | 1987-12-17 | 의 약 품 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4835173A (enExample) |
| EP (1) | EP0276559B1 (enExample) |
| JP (1) | JP2732844B2 (enExample) |
| KR (1) | KR880007073A (enExample) |
| AT (1) | ATE79031T1 (enExample) |
| AU (1) | AU608794B2 (enExample) |
| CY (1) | CY1693A (enExample) |
| DE (1) | DE3780940T2 (enExample) |
| DK (1) | DK662787A (enExample) |
| ES (1) | ES2051754T3 (enExample) |
| GB (1) | GB8630071D0 (enExample) |
| GR (1) | GR3005682T3 (enExample) |
| HK (1) | HK36593A (enExample) |
| IE (1) | IE60135B1 (enExample) |
| IL (1) | IL84844A0 (enExample) |
| NZ (1) | NZ222949A (enExample) |
| PH (1) | PH25503A (enExample) |
| ZA (1) | ZA879458B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0278173B1 (en) * | 1986-12-17 | 1993-11-03 | Glaxo Group Limited | Use of heterocyclic derivatives in the treatment of depressions |
| US5246941A (en) | 1986-12-17 | 1993-09-21 | Glaxo Group Limited | Method for the treatment of depression |
| US5221687A (en) * | 1988-09-01 | 1993-06-22 | Glaxo Group Limited | Medicaments |
| GB8820653D0 (en) * | 1988-09-01 | 1988-10-05 | Glaxo Group Ltd | Medicaments |
| US5180728A (en) * | 1989-09-25 | 1993-01-19 | Fujisawa Pharmaceutical Company, Ltd. | Pyrimidoindole derivatives and processes for preparation thereof |
| US5225407A (en) * | 1990-02-22 | 1993-07-06 | Glaxo Group Limited | 5-HT3 receptor antagonists for the treatment of autism |
| AU2295792A (en) * | 1991-06-26 | 1993-01-25 | Sepracor, Inc. | Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron |
| CA2371822A1 (en) | 1999-03-01 | 2000-09-08 | Sepracor Inc. | Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron |
| US20020107275A1 (en) * | 2000-10-30 | 2002-08-08 | Ramy Lidor-Hadas | Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation |
| EP1207160A1 (en) * | 2000-11-20 | 2002-05-22 | Hanmi Pharm. Co., Ltd. | Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one |
| YU56103A (sh) * | 2001-01-11 | 2006-05-25 | Teva Pharmaceutical Industries Ltd. | Poboljšani postupak za pripremanje čistog ondansetron hidrohlorid dihidrata |
| US20020115707A1 (en) * | 2001-01-11 | 2002-08-22 | Rami Lidor-Hadas | Process for preparing pure ondansetron hydrochloride dihydrate |
| CN1665823A (zh) | 2002-04-29 | 2005-09-07 | 特瓦药厂有限公司 | 制备1,2,3,9－四氢－9－甲基－3－[(2－甲基－1h－咪唑－1－基)甲基]－4h－咔唑－4－酮的方法 |
| US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
| KR20040104677A (ko) * | 2002-04-30 | 2004-12-10 | 비오갈 기오기스제르갸르 알티. | 신규의 온단세트론 결정 형태, 그 제조 방법, 그 신규의결정 형태를 함유하는 약학 조성물 및 이들을 이용한구역질 치료 방법 |
| HU225885B1 (en) * | 2002-10-17 | 2007-11-28 | Richter Gedeon Nyrt | Process for producing ondansetron hydrochlorid dihydrate of high purity |
| WO2009027564A1 (es) * | 2007-08-08 | 2009-03-05 | Legarda Ibanez Juan Jose | Uso y métodos de uso de un antagonista del receptor (5-ht3) de la serotonina3 y un modulador selectivo de los canales de cloruro para el tratamiento de la adicción a o la dependencia de fármacos/drogas o trastornos del sistema nervioso central |
| US12403152B2 (en) | 2018-06-21 | 2025-09-02 | Societe Des Produits Nestle S.A. | Compositions and methods using a nicotinamide adenine dinucleotide (NAD+) precursor and at least one ketone or ketone precursor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN158970B (enExample) * | 1981-06-09 | 1987-02-28 | Ici Plc | |
| SE460359B (sv) * | 1984-01-25 | 1989-10-02 | Glaxo Group Ltd | 3-imidazolylmetyltetrahydrokarbazoloner, foerfarande foer framstaellning av dessa och en farmaceutisk komposition |
| GB8401888D0 (en) * | 1984-01-25 | 1984-02-29 | Glaxo Group Ltd | Heterocyclic compounds |
| DE3688296T2 (de) * | 1985-03-14 | 1993-11-04 | Beecham Group Plc | Arzneimittel zur behandlung von erbrechen. |
| GB8516083D0 (en) * | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
| GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
| NL8701682A (nl) * | 1986-07-30 | 1988-02-16 | Sandoz Ag | Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten. |
-
1986
- 1986-12-17 GB GB868630071A patent/GB8630071D0/en active Pending
-
1987
- 1987-12-16 NZ NZ222949A patent/NZ222949A/en unknown
- 1987-12-16 PH PH36241A patent/PH25503A/en unknown
- 1987-12-16 AU AU82617/87A patent/AU608794B2/en not_active Ceased
- 1987-12-16 IE IE341587A patent/IE60135B1/en not_active IP Right Cessation
- 1987-12-16 US US07/133,887 patent/US4835173A/en not_active Expired - Lifetime
- 1987-12-16 DE DE8787311082T patent/DE3780940T2/de not_active Expired - Lifetime
- 1987-12-16 DK DK662787A patent/DK662787A/da not_active Application Discontinuation
- 1987-12-16 EP EP87311082A patent/EP0276559B1/en not_active Expired - Lifetime
- 1987-12-16 JP JP62318455A patent/JP2732844B2/ja not_active Expired - Lifetime
- 1987-12-16 AT AT87311082T patent/ATE79031T1/de not_active IP Right Cessation
- 1987-12-16 ES ES87311082T patent/ES2051754T3/es not_active Expired - Lifetime
- 1987-12-16 IL IL84844A patent/IL84844A0/xx not_active IP Right Cessation
- 1987-12-17 ZA ZA879458A patent/ZA879458B/xx unknown
- 1987-12-17 KR KR870014390A patent/KR880007073A/ko not_active Ceased
-
1992
- 1992-09-10 GR GR920402010T patent/GR3005682T3/el unknown
-
1993
- 1993-04-15 HK HK365/93A patent/HK36593A/en not_active IP Right Cessation
-
1994
- 1994-01-14 CY CY169394A patent/CY1693A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2732844B2 (ja) | 1998-03-30 |
| EP0276559B1 (en) | 1992-08-05 |
| PH25503A (en) | 1991-07-24 |
| IE873415L (en) | 1988-06-17 |
| EP0276559A3 (en) | 1989-10-18 |
| DE3780940T2 (de) | 1992-12-24 |
| DK662787A (da) | 1988-06-18 |
| GB8630071D0 (en) | 1987-01-28 |
| AU608794B2 (en) | 1991-04-18 |
| NZ222949A (en) | 1997-06-24 |
| HK36593A (en) | 1993-04-23 |
| GR3005682T3 (enExample) | 1993-06-07 |
| CY1693A (en) | 1994-01-14 |
| DK662787D0 (da) | 1987-12-16 |
| EP0276559A2 (en) | 1988-08-03 |
| ES2051754T3 (es) | 1994-07-01 |
| DE3780940D1 (de) | 1992-09-10 |
| IL84844A0 (en) | 1988-06-30 |
| AU8261787A (en) | 1988-06-23 |
| US4835173A (en) | 1989-05-30 |
| JPS63165314A (ja) | 1988-07-08 |
| ZA879458B (en) | 1988-11-30 |
| ATE79031T1 (de) | 1992-08-15 |
| IE60135B1 (en) | 1994-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19871217 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19921216 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19871217 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19951012 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19960402 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19951012 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |