KR880005119A - 9,10-안트라 쎈디카르복스알데히드의 비스(2-이미다졸린-2-일히드라존)의 아실화 생성물 및 그 제조방법 - Google Patents
9,10-안트라 쎈디카르복스알데히드의 비스(2-이미다졸린-2-일히드라존)의 아실화 생성물 및 그 제조방법 Download PDFInfo
- Publication number
- KR880005119A KR880005119A KR870011805A KR870011805A KR880005119A KR 880005119 A KR880005119 A KR 880005119A KR 870011805 A KR870011805 A KR 870011805A KR 870011805 A KR870011805 A KR 870011805A KR 880005119 A KR880005119 A KR 880005119A
- Authority
- KR
- South Korea
- Prior art keywords
- dihydro
- bis
- imidazole
- anthracenediylbis
- methylidine
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- SBRUFOSORMQHES-UHFFFAOYSA-N anthracene-9,10-dialdehyde Chemical compound C1=CC=C2C(C=O)=C(C=CC=C3)C3=C(C=O)C2=C1 SBRUFOSORMQHES-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- -1 monosubstituted phenyl Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- LXCYSACZTOKNNS-UHFFFAOYSA-N diethoxy(oxo)phosphanium Chemical compound CCO[P+](=O)OCC LXCYSACZTOKNNS-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 1
- 125000005638 hydrazono group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 하기 일반식의 화합물과 약리학적으로 허용가능한 그의 염상기 식에서, R1과 R3는 같거나 다르고 수소, 알킬(C1-C6), |[여기에서 R5는 수소, 알킬(C1-C6), 페닐, 일치환 페닐(여기에서 치환기는 오르토, 메타 또는 파라일 수 있으며 플루오로, 니트로, 알킬(C1-C6), 알콕시(C1-C3) 및 시아노이다), 펜타플루오로페닐, 나프틸, 푸라닐,,-CH2CH2COOH, -CO(CH3)3, -CH2OCH3,또는 -SO3이고 ; R2와 R4는 같거나 다르며 수소, 알킬(C1-C4) 또는[여기에서 R6는 수소, 알킬(C1-C6), 페닐, 일치환페닐(여기에서 치환기는 오르토, 메타 또는 파라 위치일 수 있으며 플루오로, 니트로, 알길(C1-C6), 알콕시(C1-C3) 또는 시아노이다), 펜타플루오로페닐, 나프틸, 푸라닐 또는 -CH2OCH3]이다.
- 제1항에 있어서, 2,2′-[9,10-안트라센디일비스(메틸리딘-1-히드라지닐-2-일리덴)]비스[4,5-디히드로-1-(옥소부틸)-1H-이미다졸], 2,2′-[9,10-안트라센디일비스(메틸리딘-1-히드라지닐-2-일리덴]비스[4,5-디히드로-1-감마-옥소-1H-이미다졸-1-부타노익산][9,10-안트라센디일비스[메틸리딘-1-히드라지닐-2-일리덴(4,5-디히드로-1H-이미다졸-2,1-디일)]]비스포스폰산, 테트라에틸 에스테르, [9,10-안트라센디일비스[메틸리딘-1-히드라지닐-2-일리덴(4,5-디히드로-1H-이미다졸-2,1-디일)]]비스포스폰산, 벤조산의 2,2′-[9,10-안트라센디일디메틸리딘)비스[1-(1-벤조일-4,5-디히드로-1H-이미다졸-2-일)히드라지드], 2,2′-[9,10-안트라센디일비스(메틸리딘-1-히드라지닐-2-일리덴)]비스[4,5-디히드로-델타-옥소- 1H-이미다졸-1-펜타노익산], 2,2'-[9,10-안트라센디일비스(메틸리딘-1-히드라지닐-2-일리덴)]비스[4,5-디히드로]-1H-이미다졸-2-카르복실산], 비스-((1,1-디메틸에틸)에스테르. 3-니트로벤조산의 2,2'-(9,10-안트라센디일디메틸리딘)비스[1-4,5-디히드로-1-(3-니트로벤조일)-1H-이미다졸-2-일]히디라조노]메틸-9-안트라세닐]메틸렌]-1-(4,-디히드로-1H-이미다졸-2-일)히드라지드 또는(R*, R*)], [9,10-안트라센디일비스(메틸리딘-1-히드라지닐-2-일리덴)]비스[1-(2-아미노-1-옥소프로필)-4,5-디히드로-1H-이미다졸]테트라히드로클로라이드, [9,10-안트라센디일비스[메틸리딘-1-히드라지닐-2-일리덴(4,5-디히드로-1H-이미다졸-2,1-디일)]]포스폰산, 디에틸 에스테르, [9,10-안트라센디일비스[메틸리딘-1-히드라지닐-2-일리덴(4,5-디히드로-1H-이미다졸-2,1-디일)]]포스폰산 또는 [2-[[[10-[[4,5-디히드로-1H-이미다졸-2-일)에틸히드라조노]메틸]-9-안트라세닐]메틸렌]히드라지노]-4,5-디히드로-1H-이미다졸-1-일]포스폰산인 화합물.
- 제1항의 화합물의 종양세포붕괴 양을 온혈 동물에 투여하는 것을 포함하는 상기 동물에서 종양을 치료하는 방법.
- 포유동물 체표면적 ㎡당 제1항의 화합물 약 1mg 약 1.2g과 함께 제약상 허용 가능한 담체를 포함하는 투약단위 형태의 조성물질.
- 유기 용매속에서 9,10-안트라센디카르복스알데히드의 비스(2-이미다졸린-2-일히드라존) 현탁액과 아실화제를 반응시킴을 특징으로 하는 하기 일반식의 화합물을 제조하는 방법.상기 식에서 R1과 R2, R3와 R4는 제1항에서 정의한 바와 같다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92222086A | 1986-10-23 | 1986-10-23 | |
| US922220 | 1986-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR880005119A true KR880005119A (ko) | 1988-06-28 |
Family
ID=25446718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR870011805A KR880005119A (ko) | 1986-10-23 | 1987-10-22 | 9,10-안트라 쎈디카르복스알데히드의 비스(2-이미다졸린-2-일히드라존)의 아실화 생성물 및 그 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0264901B1 (ko) |
| JP (1) | JPS63115868A (ko) |
| KR (1) | KR880005119A (ko) |
| AT (1) | ATE109773T1 (ko) |
| AU (1) | AU602537B2 (ko) |
| CA (1) | CA1321204C (ko) |
| DE (1) | DE3750358D1 (ko) |
| DK (1) | DK553587A (ko) |
| FI (1) | FI874653A (ko) |
| HU (1) | HU206087B (ko) |
| IL (1) | IL84213A (ko) |
| NO (1) | NO170331C (ko) |
| NZ (1) | NZ222250A (ko) |
| PH (1) | PH25711A (ko) |
| PT (1) | PT85982B (ko) |
| ZA (1) | ZA877951B (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0338372A3 (en) * | 1988-04-22 | 1991-10-09 | American Cyanamid Company | Solubilized pro-drugs |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996372A (en) * | 1975-12-03 | 1976-12-07 | Shell Oil Company | Insecticidal 1-acyl-3-substituted-2-(nitro(phenylthio)-methylene)imidazolidines |
| GB2009171B (en) * | 1977-11-28 | 1982-08-18 | American Cyanamid Co | Anthracene bis-carbonyl hydrazones and derivatives |
| US4258181A (en) * | 1978-09-05 | 1981-03-24 | American Cyanamid Company | Substituted 9,10-anthracenebishydrazones |
| DE3133887A1 (de) * | 1981-08-27 | 1983-03-10 | Bayer Ag, 5090 Leverkusen | 2-arylhydrazino-2-imidazoline, deren acylderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von endo- und ektoparasiten |
-
1987
- 1987-10-19 IL IL84213A patent/IL84213A/xx not_active IP Right Cessation
- 1987-10-20 DE DE3750358T patent/DE3750358D1/de not_active Expired - Lifetime
- 1987-10-20 AT AT87115324T patent/ATE109773T1/de active
- 1987-10-20 EP EP87115324A patent/EP0264901B1/en not_active Expired - Lifetime
- 1987-10-21 CA CA000549838A patent/CA1321204C/en not_active Expired - Fee Related
- 1987-10-21 NZ NZ222250A patent/NZ222250A/en unknown
- 1987-10-22 FI FI874653A patent/FI874653A/fi not_active Application Discontinuation
- 1987-10-22 ZA ZA877951A patent/ZA877951B/xx unknown
- 1987-10-22 AU AU80033/87A patent/AU602537B2/en not_active Ceased
- 1987-10-22 DK DK553587A patent/DK553587A/da not_active Application Discontinuation
- 1987-10-22 KR KR870011805A patent/KR880005119A/ko not_active Application Discontinuation
- 1987-10-22 NO NO874404A patent/NO170331C/no unknown
- 1987-10-23 JP JP62268027A patent/JPS63115868A/ja active Pending
- 1987-10-23 HU HU874751A patent/HU206087B/hu not_active IP Right Cessation
- 1987-10-23 PT PT85982A patent/PT85982B/pt not_active IP Right Cessation
- 1987-10-23 PH PH35977A patent/PH25711A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63115868A (ja) | 1988-05-20 |
| FI874653A0 (fi) | 1987-10-22 |
| NO874404D0 (no) | 1987-10-22 |
| DE3750358D1 (de) | 1994-09-15 |
| PH25711A (en) | 1991-09-18 |
| AU8003387A (en) | 1988-04-28 |
| PT85982A (en) | 1987-11-01 |
| AU602537B2 (en) | 1990-10-18 |
| EP0264901B1 (en) | 1994-08-10 |
| DK553587A (da) | 1988-04-24 |
| NO170331C (no) | 1992-10-07 |
| HUT45505A (en) | 1988-07-28 |
| NZ222250A (en) | 1990-04-26 |
| IL84213A0 (en) | 1988-03-31 |
| FI874653A (fi) | 1988-04-24 |
| EP0264901A1 (en) | 1988-04-27 |
| ATE109773T1 (de) | 1994-08-15 |
| IL84213A (en) | 1992-09-06 |
| PT85982B (pt) | 1990-08-31 |
| ZA877951B (en) | 1988-04-26 |
| NO170331B (no) | 1992-06-29 |
| HU206087B (en) | 1992-08-28 |
| CA1321204C (en) | 1993-08-10 |
| NO874404L (no) | 1988-04-25 |
| DK553587D0 (da) | 1987-10-22 |
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