KR880002223B1 - 정제해독된 내독소 - Google Patents

정제해독된 내독소 Download PDF

Info

Publication number
KR880002223B1
KR880002223B1 KR1019840005189A KR840005189A KR880002223B1 KR 880002223 B1 KR880002223 B1 KR 880002223B1 KR 1019840005189 A KR1019840005189 A KR 1019840005189A KR 840005189 A KR840005189 A KR 840005189A KR 880002223 B1 KR880002223 B1 KR 880002223B1
Authority
KR
South Korea
Prior art keywords
rde
endotoxin
composition
spp
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840005189A
Other languages
English (en)
Korean (ko)
Other versions
KR850001696A (ko
Inventor
에른스트 리비 에드가
Original Assignee
리비 이뮤노켐 리서어치 인코오퍼레이션
닐스 에이.리비
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리비 이뮤노켐 리서어치 인코오퍼레이션, 닐스 에이.리비 filed Critical 리비 이뮤노켐 리서어치 인코오퍼레이션
Publication of KR850001696A publication Critical patent/KR850001696A/ko
Application granted granted Critical
Publication of KR880002223B1 publication Critical patent/KR880002223B1/ko
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019840005189A 1983-08-26 1984-08-25 정제해독된 내독소 Expired KR880002223B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52696783A 1983-08-26 1983-08-26
US526967 1983-08-26
US526,967 1983-08-26

Publications (2)

Publication Number Publication Date
KR850001696A KR850001696A (ko) 1985-04-01
KR880002223B1 true KR880002223B1 (ko) 1988-10-20

Family

ID=24099553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840005189A Expired KR880002223B1 (ko) 1983-08-26 1984-08-25 정제해독된 내독소

Country Status (22)

Country Link
JP (1) JPS6072825A (enrdf_load_stackoverflow)
KR (1) KR880002223B1 (enrdf_load_stackoverflow)
AT (1) AT389228B (enrdf_load_stackoverflow)
AU (1) AU554039B2 (enrdf_load_stackoverflow)
BE (1) BE900377A (enrdf_load_stackoverflow)
CA (1) CA1225592A (enrdf_load_stackoverflow)
CH (1) CH660125A5 (enrdf_load_stackoverflow)
DE (2) DE3431058A1 (enrdf_load_stackoverflow)
DK (1) DK389384A (enrdf_load_stackoverflow)
ES (1) ES8606883A1 (enrdf_load_stackoverflow)
FI (1) FI843204L (enrdf_load_stackoverflow)
FR (1) FR2550945B1 (enrdf_load_stackoverflow)
GB (1) GB2147806B (enrdf_load_stackoverflow)
HU (1) HU191713B (enrdf_load_stackoverflow)
IL (1) IL72675A (enrdf_load_stackoverflow)
IN (1) IN157910B (enrdf_load_stackoverflow)
IT (1) IT1177974B (enrdf_load_stackoverflow)
NL (1) NL192326C (enrdf_load_stackoverflow)
NO (1) NO843243L (enrdf_load_stackoverflow)
NZ (1) NZ209233A (enrdf_load_stackoverflow)
SE (1) SE8404090L (enrdf_load_stackoverflow)
ZA (1) ZA846309B (enrdf_load_stackoverflow)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
DE10115310A1 (de) * 2001-03-28 2002-10-10 Nodar A Daniela Bakteriophagen-Präparation
KR100868443B1 (ko) * 2002-05-27 2008-11-11 주식회사 포스코 폭과 길이가 가변 조정되는 런치박스 제작장치

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160326B1 (enrdf_load_stackoverflow) * 1971-11-19 1975-02-07 Anvar
BE793260A (fr) * 1971-12-24 1973-06-22 Pasteur Institut Agent immunostimulant, medicaments le contenant et procede de fabrication de cet agent immunostimulant
DE2527636A1 (de) * 1974-06-20 1976-01-08 Anvar Verfahren zur herstellung von mycobakteriellen fraktionen
FR2393065A1 (fr) * 1977-05-31 1978-12-29 Merieux Inst Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4435386A (en) * 1982-05-26 1984-03-06 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product

Also Published As

Publication number Publication date
IN157910B (enrdf_load_stackoverflow) 1986-07-19
IL72675A0 (en) 1984-11-30
SE8404090D0 (sv) 1984-08-14
FI843204A7 (fi) 1985-02-27
ES535124A0 (es) 1986-05-01
IT8448757A1 (it) 1986-02-24
FR2550945A1 (fr) 1985-03-01
GB2147806B (en) 1986-10-22
HU191713B (en) 1987-03-30
AT389228B (de) 1989-11-10
AU3221584A (en) 1985-02-28
CH660125A5 (de) 1987-03-31
JPH0556326B2 (enrdf_load_stackoverflow) 1993-08-19
GB8420612D0 (en) 1984-09-19
IT8448757A0 (it) 1984-08-24
DK389384D0 (da) 1984-08-13
FI843204A0 (fi) 1984-08-14
CA1225592A (en) 1987-08-18
NO843243L (no) 1985-02-27
JPS6072825A (ja) 1985-04-24
BE900377A (fr) 1985-02-18
ATA273384A (de) 1989-04-15
NL192326C (nl) 1997-06-04
ZA846309B (en) 1985-03-27
KR850001696A (ko) 1985-04-01
NL192326B (nl) 1997-02-03
IT1177974B (it) 1987-09-03
DE3448164C2 (enrdf_load_stackoverflow) 1987-06-25
SE8404090L (sv) 1985-02-27
AU554039B2 (en) 1986-08-07
IL72675A (en) 1988-04-29
GB2147806A (en) 1985-05-22
FI843204L (fi) 1985-02-27
NL8402515A (nl) 1985-03-18
NZ209233A (en) 1987-11-27
HUT34887A (en) 1985-05-28
DE3431058C2 (enrdf_load_stackoverflow) 1987-06-11
FR2550945B1 (fr) 1988-09-16
DK389384A (da) 1985-02-27
ES8606883A1 (es) 1986-05-01
DE3431058A1 (de) 1985-03-07

Similar Documents

Publication Publication Date Title
US4866034A (en) Refined detoxified endotoxin
KR870000842B1 (ko) 정제 해독된 내독소 및 그의 제조방법
US4436728A (en) Refined detoxified endotoxin product
US4877611A (en) Vaccine containing tumor antigens and adjuvants
US4877612A (en) Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
US4435386A (en) Refined detoxified endotoxin product
US4036953A (en) Process for preparing vaccine adjuvant
KR870000843B1 (ko) 피리딘 가용성 추출물의 제조방법
Ribi et al. Preparation and antitumor activity of nontoxic lipid A
US4505900A (en) Refined detoxified endotoxin product
US4505899A (en) Refined detoxified endotoxin product
US4152423A (en) Immunological agents
KR880002223B1 (ko) 정제해독된 내독소
JP2709979B2 (ja) マイコバクテリウムケロナエの極性糖ペプチド脂質に基づく免疫刺激薬
RU2260053C2 (ru) Способ выделения биологически активной фракции (баф), содержащей s-липополисахариды (s-лпс) из грамотрицательных бактерий, баф для лечения и профилактики заболеваний, вызываемых грамотрицательными бактериями, производящими эндотоксичные s-лпс, фармацевтическая композиция, способы индукции протективного иммунитета и улучшения состояния пациента при состояниях, требующих повышения иммунного статуса
HU185315B (en) Siliconpolymer compositions for treating textile materials
RU2111012C1 (ru) Вакцинный препарат для профилактики брюшного тифа
AU615016B2 (en) Immunological adjuvent and process for preparing the same, pharmaceutical compositions, and process
Lederer Cord factor and related synthetic trehalose diesters
KITAGAWA et al. Chemical Studies on Cellular Components of Hemophilus pertussis II. Isolation of Toxic Lipopolysaccharide

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

J2X1 Appeal (before the patent court)

Free format text: APPEAL AGAINST DECISION TO DECLINE REFUSAL

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19911021

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19911021

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000