KR870006054A - 치료 시스템의 제조방법 - Google Patents
치료 시스템의 제조방법Info
- Publication number
- KR870006054A KR870006054A KR860010686A KR860010686A KR870006054A KR 870006054 A KR870006054 A KR 870006054A KR 860010686 A KR860010686 A KR 860010686A KR 860010686 A KR860010686 A KR 860010686A KR 870006054 A KR870006054 A KR 870006054A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- active substance
- optionally
- weight
- storage layer
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 239000013543 active substance Substances 0.000 claims 8
- 239000010410 layer Substances 0.000 claims 5
- 239000004908 Emulsion polymer Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 125000004494 ethyl ester group Chemical group 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001477 organic nitrogen group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- ZNXAJGZPUQOEDZ-UHFFFAOYSA-N 6-ethyl-4,5,7,8-tetrahydro-[1,3]oxazolo[4,5-d]azepin-2-amine Chemical group C1CN(CC)CCC2=C1OC(N)=N2 ZNXAJGZPUQOEDZ-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 239000005062 Polybutadiene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- -1 hexahydrobenzyl Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000001050 lubricating effect Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 230000007096 poisonous effect Effects 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920002239 polyacrylonitrile Polymers 0.000 claims 1
- 229920002857 polybutadiene Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 229920001290 polyvinyl ester Polymers 0.000 claims 1
- 239000011241 protective layer Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Materials For Medical Uses (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 염기성 말단 그룹을 갖는 에멀젼 중합체 1 내지 50중량%를 임의로 함유하는 에멀젼 중합체 또는 에멀젼 공중합체를 일반식(I)의 활성물질 또는 이의 생리학적으로 무독한 [무기 또는 유기산과의 산부가염과 함께, 임의로는 활성물질의 양을 기준으로 하여 1 내지 5중량%의 유기 질소-함유 염기를 가하면서 유기 용매에 용해시키고 쏟아부어 필름을 형성시킨다음 건조시키고, 필름을 활정물질에 대해 불투과성인 배면층 및 제거가능한 보호층에 임의로 적용시켜 포장함을 특징으로 하여, 활성물질에 대해 불투과성인 배면층, 활성물질을 함유하는 저장층 및 피부에 부착하기 위한 재료로 이루어지며 활성물질의 경피 투여를 위한 피부 플라스틱 형태의 치료 시스템을 제조하는 방법.상기식에서, R1은 수소원자; 하이드록실 그룹에 의해 임의로 치환된 탄소수 1 내지 4의 직쇄 또는 측쇄알킬 그룹;또는 알릴, 사이클로알킬, 헥사하이드로벤질, 페닐, 페닐에틸 또는 벤질그룹을 나타내며, 여기에서 벤질그룹은 핵부위에서 1 또는 2개의 할로겐 원자, 1 내지 3개의 메톡시그룹, 또는 탄소수 1 내지 3의 알킬 또는 트리플루오로메탈 그룹에 의해 치환될 수 있고, X가 황원자이면, R2는 수소원자, 탄소수 1 내지 5의 직쇄 또는 측쇄 알킬 그룹, 알릴그룹, 사이클로알킬그룹, 페닐그룹, 벤질그룹 또는 페닐에틸그룹을 나타내거나, X가 산소원자이면, R2는 수소원자를 나타낸다.
- 제1항에 있어서, 활성물질이 2-아미노-6-에틸-4,5,7,8-테트라하이드르-6H-옥사졸로[5,4-d] 아제핀 또는 그의 약물학적으로 무독한 산부가염인 방법.
- 제1항에 있어서, 활성 물질이 6-알릴-2-아미노-6-에틸-4,5,7,8-테트라하이드로-6H-티아졸로[5,4-d]아제핀 또는 그의 약물학적으로 무독한 산부가염인 방법.
- 제1항 내지 3항중의 어느 한항에 있어서, 저장층이 폴리비닐 클로라이드, 폴리락타이드, 폴리스티렌, 폴리비닐 아세데이트, 폴리부타디엔, 폴리아크릴로니트릴, 폴리비닐에스테르, 아크릴산의 메틸 또는 에틸에스테르, 및 메타크릴산의 메틸 또는 에틸 에스테르로 이루어진 그룹 중에서 선택된 에멀젼 중합체 또는 에멀젼 공중합체와 임의로는 중합체 전량을 기준으로 하여 1 내지 50중량%의, 염기성 말단 그룹을 갖는 에멀젼 중합체 또는 공중합체로 이루어지는 방법.
- 제4항에 있어서, 저장층이 활성 성분의 양을 기준으로하여 0.5 내지 5중량%의 유기 질소-함유 염기를 함유하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3544311 | 1985-12-14 | ||
| DEP3544311.1 | 1985-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR870006054A true KR870006054A (ko) | 1987-07-09 |
Family
ID=6288476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR860010686A KR870006054A (ko) | 1985-12-14 | 1986-12-13 | 치료 시스템의 제조방법 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4826686A (ko) |
| EP (1) | EP0227988A3 (ko) |
| JP (1) | JPS62148422A (ko) |
| KR (1) | KR870006054A (ko) |
| AU (1) | AU593863B2 (ko) |
| CA (1) | CA1291039C (ko) |
| DK (1) | DK599986A (ko) |
| FI (1) | FI865069A (ko) |
| IL (1) | IL80950A (ko) |
| NO (1) | NO865028L (ko) |
| NZ (1) | NZ218616A (ko) |
| PT (1) | PT83919B (ko) |
| ZA (1) | ZA869373B (ko) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
| EP0523150A4 (en) * | 1990-04-06 | 1993-09-29 | Pharmetrix Corporation | Device and method for enhanced administration of physostigmine |
| US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
| US5498417A (en) * | 1994-05-12 | 1996-03-12 | Coating Sciences, Inc. | Transdermal delivery of appetite suppressant drug |
| US5543133A (en) * | 1995-02-14 | 1996-08-06 | Nanosystems L.L.C. | Process of preparing x-ray contrast compositions containing nanoparticles |
| DE19653605C2 (de) * | 1996-12-20 | 2002-11-28 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems |
| ITPD20020138A1 (it) * | 2002-05-24 | 2003-11-24 | Matteo Bevilacqua | Composizione di sostanze a base terpenica, metodo di preparazione e metodo di dispersione in ambiente della medesima. |
| JP5137286B2 (ja) * | 2003-06-10 | 2013-02-06 | 帝國製薬株式会社 | フェンタニル含有口腔粘膜貼付剤 |
| CN101166531A (zh) * | 2005-04-20 | 2008-04-23 | 日绊株式会社 | 经皮吸收制剂 |
| WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG17786A3 (ko) * | 1970-08-14 | 1973-12-25 | ||
| DE2040510C3 (de) * | 1970-08-14 | 1980-03-06 | Dr. Karl Thomae Gmbh, 7950 Biberach | Oxazole- und Thiazole eckige Klammer auf 5,4-d] azepin- Derivate |
| DE2836387A1 (de) * | 1978-08-19 | 1980-02-28 | Boehringer Sohn Ingelheim | Retardform fuer einen blutdrucksenkenden und antanginoes wirkenden stoff |
| JPS56133381A (en) * | 1980-03-25 | 1981-10-19 | Nippon Kayaku Co Ltd | Pressure-sensitive adhesive tape or sheet containing nitroglycerin |
| AU553343B2 (en) * | 1981-08-10 | 1986-07-10 | Advance Electrode Kabushikikaisya | Absorbent adhesive bandage with medicament release |
| US4400378A (en) * | 1981-11-02 | 1983-08-23 | Karl Thomae Gesellschaft Mit Beschrankter Haftung | Pharmaceutical composition for the treatment of glaucoma |
| DE3204551A1 (de) * | 1982-02-10 | 1983-08-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung einer pharmazeutischen zubereitung in form eines polyacrylat-films |
| CA1225594A (en) * | 1983-05-20 | 1987-08-18 | Jourge Heller | Method for percutaneously administering physiologically active agents |
| JPS60174716A (ja) * | 1984-02-21 | 1985-09-09 | Yamanouchi Pharmaceut Co Ltd | パツチ剤 |
| DE3428342A1 (de) * | 1984-08-01 | 1986-02-13 | Boehringer Ingelheim Vetmedica GmbH, 6507 Ingelheim | Futtermittelzusatz zur verbesserung des wachstums bei landwirtschaftlichen nutztieren |
| US4690683A (en) * | 1985-07-02 | 1987-09-01 | Rutgers, The State University Of New Jersey | Transdermal varapamil delivery device |
-
1986
- 1986-12-02 US US06/937,160 patent/US4826686A/en not_active Expired - Fee Related
- 1986-12-09 EP EP86117109A patent/EP0227988A3/de not_active Withdrawn
- 1986-12-12 CA CA000525154A patent/CA1291039C/en not_active Expired - Fee Related
- 1986-12-12 PT PT83919A patent/PT83919B/pt not_active IP Right Cessation
- 1986-12-12 DK DK599986A patent/DK599986A/da not_active Application Discontinuation
- 1986-12-12 NZ NZ218616A patent/NZ218616A/xx unknown
- 1986-12-12 JP JP61296489A patent/JPS62148422A/ja active Pending
- 1986-12-12 IL IL80950A patent/IL80950A/xx unknown
- 1986-12-12 ZA ZA869373A patent/ZA869373B/xx unknown
- 1986-12-12 FI FI865069A patent/FI865069A/fi not_active IP Right Cessation
- 1986-12-12 AU AU66450/86A patent/AU593863B2/en not_active Ceased
- 1986-12-12 NO NO865028A patent/NO865028L/no unknown
- 1986-12-13 KR KR860010686A patent/KR870006054A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL80950A (en) | 1991-05-12 |
| US4826686A (en) | 1989-05-02 |
| NO865028L (no) | 1987-06-15 |
| JPS62148422A (ja) | 1987-07-02 |
| EP0227988A2 (de) | 1987-07-08 |
| AU593863B2 (en) | 1990-02-22 |
| DK599986D0 (da) | 1986-12-12 |
| AU6645086A (en) | 1987-06-18 |
| PT83919A (en) | 1987-01-01 |
| DK599986A (da) | 1987-06-15 |
| CA1291039C (en) | 1991-10-22 |
| FI865069A (fi) | 1987-06-15 |
| FI865069A0 (fi) | 1986-12-12 |
| EP0227988A3 (de) | 1990-04-11 |
| PT83919B (pt) | 1989-05-12 |
| ZA869373B (en) | 1988-08-31 |
| NO865028D0 (no) | 1986-12-12 |
| NZ218616A (en) | 1990-02-26 |
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