KR870002068A - 사이클로헥산 알카노산 및 그의 제조방법 - Google Patents

사이클로헥산 알카노산 및 그의 제조방법 Download PDF

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KR870002068A
KR870002068A KR1019860006983A KR860006983A KR870002068A KR 870002068 A KR870002068 A KR 870002068A KR 1019860006983 A KR1019860006983 A KR 1019860006983A KR 860006983 A KR860006983 A KR 860006983A KR 870002068 A KR870002068 A KR 870002068A
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South Korea
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loweralkyl
hydroxy
compound
integer
tetradecylidene
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KR1019860006983A
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KR900002821B1 (ko
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제이. 크레그 로버트
에스. 사볼 제프리
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개리 디. 스트리트
메렐 다우 파마슈 티컬스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

내용 없음.

Description

사이클로헥산 알카노산 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(I)의 화합물.
    상기 식에서, m은 1 내지 5의 정수이고; n은 0 내지 2의 정수이며; R은 탄소원자 8 내지 15개를 함유하는 직쇄 알킬이고; X는 수소이거나, n이 1 또는 2인 경우에는 -NH2일 수 있고; Y는 하이드록시, -O-(저급알킬), -NH2, -NH-(저급알킬), -N-(저급알킬)2또는 -NHCH2COOH이며; Z는 하이드록시, -O-(저급알킬), -NH2, -NH-(저급알킬), 또는 -N-(저급알킬)2이다.
  2. 제1항에 있어서, 하기 일반식(II)로 표시되는 화합물.
    상기 식에서, m은 1 내지 5의 정수이고; n은 0 내지 2의 정수이며; R은 탄소원자 8 내지 15개를 함유하는 직쇄 알킬이며; X는 수소이거나, n이 1 또는 2인 경우에는 X는 -NH2일 수 있다.
  3. 제1항에 있어서, 하기 일반식(III)으로 표시되는 화합물.
    상기 식에서, m은 1 내지 5의 정수이고; n은 0 내지 2의 정수이다.
  4. 제1항에 있어서, (1α,2β,3α,4E)-3-[(카복시메틸)티오]-2-하이드록시-4-테트라 데실리덴 사이클로 헥산 아세트산인 화합물.
  5. 제1항에 있어서, (1α,2β,3α,4E)-3-[(2-카복시에틸)티오]-2-하이드록 시-4-테트라 데실리덴 사이클로 헥산 아세트산인 화합물.
  6. 제1항에 있어서, (1α,2α,3β,4E)-3-[(카복시메틸)티오]-2-하이드록시-4-테트라 데실리덴 사이클로 헥산 프로피온산인 화합물.
  7. 제1항에 있어서, (1α,2α,3β,4E)-3-[(2-카복시에틸)티오]-2-하이드록 시-4-테트라 데실리덴 사이클로 헥산 프로피온산인 화합물.
  8. 제1항에 있어서, (1α,2β,3α,4E)-3-[(카복시메틸)티오]-2-하이드록시-4-테트라 데실리덴 사이클로 헥산 프로피온산인 화합물.
  9. 제1항에 있어서, (1α,2α,3α,4E)-3-[(카복시메틸)티오]-2-하이드록시-4-테트라 데실리덴 사이클로 헥산 아세트산인 화합물.
  10. 일반식(IV)의 에폭시드를 염기의 존재하에, 적절한 용매 중에서 일반식(V)의 머캅토 알카노산 유도체와 반응시키고, 임의로 계속해서 Y′,Y″ 또는 Z′가 -O-(저급알킬)인 경우에는, 무기 강염기로 처리한 다음 강산으로 산성화시켜 Y,Y″ 또는 Z가 -OH인 화합물을 수득함을 특징으로 하여, 일반식(I)의 화합물을 제조하는 방법.
    상기 식에서, m은 1 내지 5의 정수이고; n은 0 내지 2의 정수이며; R은 탄소원자 8 내지 15개를 함유하는 알킬이고; X는 수소이거나, n이 1 또는 2인 경우에는 -NH2일 수 있고; Y는 하이드록시, -O-(저급알킬), -NH2, -NH(저급알킬), -N-(저급 알킬)2또는 -NHCH2COOH이며; Z는 하이드록시, -O-(저급알킬), -NH2, -NH-(저급알킬), -N-(저급알킬)2이고; Z′은 -O-(저급알킬), -NH2, -NH-(저급알킬), 또는 -N-(저급알킬)2이며; X′은 수소이거나, n이 1 또는 2인 경우에는 Q-NH-일 수 있으며, 여기에서, Q는 아민-보호-그룹이며; Y′은 -O-(저급알킬), -NH2, -NH-(저급알킬), -N-(저급알킬)2또는이며 여기에서, Y″은 -O-(저급알킬)이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860006983A 1985-08-23 1986-08-23 사이클로헥산 알카노산 및 그의 제조방법 KR900002821B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US768769 1985-08-23
US06/768,769 US4622422A (en) 1985-08-23 1985-08-23 Cyclohexanealkanoic acids
US768,769 1985-08-23

Publications (2)

Publication Number Publication Date
KR870002068A true KR870002068A (ko) 1987-03-28
KR900002821B1 KR900002821B1 (ko) 1990-05-01

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ID=25083435

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KR1019860006983A KR900002821B1 (ko) 1985-08-23 1986-08-23 사이클로헥산 알카노산 및 그의 제조방법

Country Status (21)

Country Link
US (1) US4622422A (ko)
EP (1) EP0213547B1 (ko)
JP (1) JPS6248663A (ko)
KR (1) KR900002821B1 (ko)
CN (1) CN1019195B (ko)
AR (1) AR241179A1 (ko)
AT (1) ATE59382T1 (ko)
AU (1) AU605466B2 (ko)
CA (1) CA1283250C (ko)
DE (1) DE3676594D1 (ko)
DK (1) DK401786A (ko)
ES (1) ES2001573A6 (ko)
FI (1) FI84263C (ko)
GR (1) GR862164B (ko)
HU (1) HU196744B (ko)
IL (1) IL79770A0 (ko)
NO (1) NO164533C (ko)
NZ (1) NZ217249A (ko)
PH (1) PH22129A (ko)
PT (1) PT83238B (ko)
ZA (1) ZA866216B (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748274A (en) * 1986-11-07 1988-05-31 Merrell Dow Pharmaceuticals Inc. 4-hydroxy-4-(substituted alkenyl)cyclohexanecarboxylic acids
US6863111B1 (en) 2000-10-03 2005-03-08 Tser-Wen Chou Positive engagement end stop for window covering systems
JP4746511B2 (ja) * 2006-10-23 2011-08-10 株式会社東芝 固体高分子型燃料電池システム

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NO863388D0 (no) 1986-08-22
FI84263C (fi) 1991-11-11
FI863410A0 (fi) 1986-08-22
KR900002821B1 (ko) 1990-05-01
CA1283250C (en) 1991-04-16
DK401786D0 (da) 1986-08-22
PH22129A (en) 1988-06-01
IL79770A0 (en) 1986-11-30
FI863410A (fi) 1987-02-24
ZA866216B (en) 1987-03-25
ATE59382T1 (de) 1991-01-15
DE3676594D1 (de) 1991-02-07
EP0213547A1 (en) 1987-03-11
AU605466B2 (en) 1991-01-17
EP0213547B1 (en) 1990-12-27
NZ217249A (en) 1989-11-28
HU196744B (en) 1989-01-30
NO863388L (no) 1987-02-24
FI84263B (fi) 1991-07-31
DK401786A (da) 1987-02-24
CN1019195B (zh) 1992-11-25
GR862164B (en) 1986-12-23
HUT43813A (en) 1987-12-28
CN86105165A (zh) 1987-04-08
NO164533C (no) 1990-10-17
PT83238A (en) 1986-09-01
PT83238B (pt) 1988-07-01
AU6164786A (en) 1987-02-26
NO164533B (no) 1990-07-09
JPS6248663A (ja) 1987-03-03
US4622422A (en) 1986-11-11
ES2001573A6 (es) 1988-06-01
AR241179A1 (es) 1992-01-31

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