KR870001070B1 - 비스-에스테르 항균제의 제조방법 - Google Patents

비스-에스테르 항균제의 제조방법 Download PDF

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Publication number
KR870001070B1
KR870001070B1 KR1019840001662A KR840001662A KR870001070B1 KR 870001070 B1 KR870001070 B1 KR 870001070B1 KR 1019840001662 A KR1019840001662 A KR 1019840001662A KR 840001662 A KR840001662 A KR 840001662A KR 870001070 B1 KR870001070 B1 KR 870001070B1
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KR
South Korea
Prior art keywords
acid
formula
added
compound
mixture
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KR1019840001662A
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English (en)
Korean (ko)
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KR840008918A (ko
Inventor
죤 제이시스 바이토터스
Original Assignee
화이자 인코포레이티드
윌리엄 데이비스 휸
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Publication of KR840008918A publication Critical patent/KR840008918A/ko
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Publication of KR870001070B1 publication Critical patent/KR870001070B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catching Or Destruction (AREA)
  • Tents Or Canopies (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019840001662A 1983-03-31 1984-03-30 비스-에스테르 항균제의 제조방법 Expired KR870001070B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US481,108 1983-03-31
US06/481,108 US4462934A (en) 1983-03-31 1983-03-31 Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US481108 1983-03-31

Publications (2)

Publication Number Publication Date
KR840008918A KR840008918A (ko) 1984-12-20
KR870001070B1 true KR870001070B1 (ko) 1987-05-27

Family

ID=23910642

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001662A Expired KR870001070B1 (ko) 1983-03-31 1984-03-30 비스-에스테르 항균제의 제조방법

Country Status (18)

Country Link
US (1) US4462934A (enExample)
EP (1) EP0121383B1 (enExample)
JP (1) JPS59216891A (enExample)
KR (1) KR870001070B1 (enExample)
AT (1) ATE19633T1 (enExample)
AU (1) AU545941B2 (enExample)
CA (1) CA1199909A (enExample)
DE (1) DE3460125D1 (enExample)
DK (1) DK114084A (enExample)
ES (1) ES531194A0 (enExample)
FI (1) FI841287A7 (enExample)
GR (1) GR79873B (enExample)
HU (1) HU191650B (enExample)
IL (1) IL71391A (enExample)
PH (1) PH22367A (enExample)
PL (1) PL144812B1 (enExample)
PT (1) PT78314B (enExample)
YU (1) YU58384A (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119627A (en) * 1996-11-17 2002-03-10 Yissum Res Dev Co PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT
EP0961614A4 (en) * 1996-12-30 2002-07-24 Univ Bar Ilan OXYALKYLESTERS CONTAINING AND USING THE TRICARBOXYL ACIDS
GB0128052D0 (en) * 2001-11-22 2002-01-16 Drug Discovery Lab As Compounds
EP1561748A4 (en) * 2002-10-18 2011-03-02 Meiji Seika Kaisha MONOESTERS OF MALONIC ACID AND METHOD OF MAKING SAME
US7973194B1 (en) 2010-03-18 2011-07-05 Eastman Chemical Company High solvating cyclohexane dicarboxylate diesters plasticizers

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US28744A (en) 1860-06-19 eaton
US2985648A (en) 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
BE639104A (enExample) 1962-11-02
US3520876A (en) 1967-11-01 1970-07-21 American Home Prod Process for the preparation of 6-(alpha-aminoacylamino)penicillanic acids
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49880B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4364957A (en) 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
US4323499A (en) * 1981-01-05 1982-04-06 Pfizer Inc. 6-(2-Aryl-2-(1,1-dioxopenicillanoyloxy-methoxycarbonyl)acetamido penicillanic acids
EP0083977A1 (en) 1982-01-11 1983-07-20 Pfizer Inc. 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor
US4377590A (en) * 1982-05-10 1983-03-22 Pfizer Inc. Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors

Also Published As

Publication number Publication date
HU191650B (en) 1987-03-30
CA1199909A (en) 1986-01-28
PH22367A (en) 1988-08-12
FI841287A0 (fi) 1984-03-30
EP0121383A1 (en) 1984-10-10
US4462934A (en) 1984-07-31
YU58384A (en) 1986-06-30
AU545941B2 (en) 1985-08-08
JPS647077B2 (enExample) 1989-02-07
DE3460125D1 (en) 1986-06-12
DK114084A (da) 1984-10-01
ATE19633T1 (de) 1986-05-15
PT78314B (en) 1986-08-08
IL71391A (en) 1987-10-30
JPS59216891A (ja) 1984-12-06
EP0121383B1 (en) 1986-05-07
PL144812B1 (en) 1988-07-30
AU2626584A (en) 1984-10-04
KR840008918A (ko) 1984-12-20
IL71391A0 (en) 1984-06-29
FI841287A7 (fi) 1984-10-01
DK114084D0 (da) 1984-02-28
PT78314A (en) 1984-04-01
GR79873B (enExample) 1984-10-31
ES8506724A1 (es) 1985-08-01
ES531194A0 (es) 1985-08-01
PL246933A1 (en) 1985-03-26

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