EP0961614A4 - Tricarboxylic acid-containing oxyalkyl esters and uses thereof - Google Patents
Tricarboxylic acid-containing oxyalkyl esters and uses thereofInfo
- Publication number
- EP0961614A4 EP0961614A4 EP97952599A EP97952599A EP0961614A4 EP 0961614 A4 EP0961614 A4 EP 0961614A4 EP 97952599 A EP97952599 A EP 97952599A EP 97952599 A EP97952599 A EP 97952599A EP 0961614 A4 EP0961614 A4 EP 0961614A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- tricarboxylic acid
- containing oxyalkyl
- oxyalkyl esters
- esters
- tricarboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/42—Glutaric acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US781905 | 1996-12-30 | ||
US08/781,905 US6130248A (en) | 1996-12-30 | 1996-12-30 | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
US81436597A | 1997-03-11 | 1997-03-11 | |
US814365 | 1997-03-11 | ||
PCT/US1997/023725 WO1998029114A1 (en) | 1996-12-30 | 1997-12-30 | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0961614A1 EP0961614A1 (en) | 1999-12-08 |
EP0961614A4 true EP0961614A4 (en) | 2002-07-24 |
Family
ID=27119918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97952599A Withdrawn EP0961614A4 (en) | 1996-12-30 | 1997-12-30 | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0961614A4 (en) |
AU (1) | AU5617398A (en) |
WO (1) | WO1998029114A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6228362B1 (en) | 1992-08-21 | 2001-05-08 | Immunomedics, Inc. | Boron neutron capture therapy using pre-targeting methods |
AU7993500A (en) * | 1999-11-15 | 2001-05-30 | New Millennium Pharmaceutical Research, Inc. | Intranasal administration of raloxifene and tamoxifen |
EP1170008A1 (en) * | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
AUPR059400A0 (en) * | 2000-10-06 | 2000-11-02 | Bar-Ilan University | Formaldehyde-releasing prodrugs |
US6562995B1 (en) * | 2000-12-21 | 2003-05-13 | Beacon Laboratories, Inc. | Delta dicarbonyl compounds and methods for using the same |
ZA200800901B (en) | 2005-07-14 | 2010-05-26 | Takeda San Diego Inc | Histone deacetylase inhibitors |
CN102123763B (en) | 2008-08-19 | 2014-10-08 | 什诺波特有限公司 | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use |
EP2887935A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
JP2015527372A (en) * | 2012-08-22 | 2015-09-17 | ゼノポート,インコーポレイティド | Method for administering monomethyl fumarate and prodrug thereof for reducing side effects |
PL2970101T3 (en) | 2013-03-14 | 2018-11-30 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various deseases |
US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
US9416096B2 (en) | 2013-09-06 | 2016-08-16 | Xenoport, Inc. | Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use |
WO2015127450A1 (en) | 2014-02-24 | 2015-08-27 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
WO2017060418A1 (en) * | 2015-10-07 | 2017-04-13 | Neurovive Pharmaceutical Ab | Protected carboxylic acid-based metabolites for the treatment of mitochondria-related diseases |
WO2017060422A1 (en) * | 2015-10-07 | 2017-04-13 | Neurovive Pharmaceutical Ab | Protected carboxylic acid-based metabolites for the treatment of mitochondrial disorders |
PL3762368T3 (en) | 2018-03-08 | 2022-06-06 | Incyte Corporation | Aminopyrazine diol compounds as pi3k-y inhibitors |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4462934A (en) * | 1983-03-31 | 1984-07-31 | Pfizer Inc. | Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides |
EP0276942A1 (en) * | 1987-01-27 | 1988-08-03 | Pfizer Inc. | 6-Beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof |
JPH06192273A (en) * | 1992-10-26 | 1994-07-12 | Lederle Japan Ltd | Carbapenem-3-carboxylic ester derivative |
-
1997
- 1997-12-30 EP EP97952599A patent/EP0961614A4/en not_active Withdrawn
- 1997-12-30 WO PCT/US1997/023725 patent/WO1998029114A1/en not_active Application Discontinuation
- 1997-12-30 AU AU56173/98A patent/AU5617398A/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4462934A (en) * | 1983-03-31 | 1984-07-31 | Pfizer Inc. | Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides |
EP0276942A1 (en) * | 1987-01-27 | 1988-08-03 | Pfizer Inc. | 6-Beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof |
JPH06192273A (en) * | 1992-10-26 | 1994-07-12 | Lederle Japan Ltd | Carbapenem-3-carboxylic ester derivative |
Non-Patent Citations (3)
Title |
---|
DATABASE WPI Derwent World Patents Index; * |
PATENT ABSTRACTS OF JAPAN vol. 018, no. 542 (C - 1261) 17 October 1994 (1994-10-17) * |
See also references of WO9829114A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU5617398A (en) | 1998-07-31 |
WO1998029114A1 (en) | 1998-07-09 |
EP0961614A1 (en) | 1999-12-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990730 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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AX | Request for extension of the european patent |
Free format text: AL PAYMENT 19990730;LT PAYMENT 19990730;LV PAYMENT 19990730;MK PAYMENT 19990730;RO PAYMENT 19990730;SI PAYMENT 19990730 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020610 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20020903 |