KR850003894A - 밀베마이신 유도체의 제조방법과 그것을 활성성분으로 하는 살충제 조성물 - Google Patents
밀베마이신 유도체의 제조방법과 그것을 활성성분으로 하는 살충제 조성물 Download PDFInfo
- Publication number
- KR850003894A KR850003894A KR1019840006869A KR840006869A KR850003894A KR 850003894 A KR850003894 A KR 850003894A KR 1019840006869 A KR1019840006869 A KR 1019840006869A KR 840006869 A KR840006869 A KR 840006869A KR 850003894 A KR850003894 A KR 850003894A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- active ingredient
- same
- compound
- reaction
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 7
- 239000004480 active ingredient Substances 0.000 title claims 3
- 239000000575 pesticide Substances 0.000 title claims 2
- 238000006243 chemical reaction Methods 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000003504 photosensitizing agent Substances 0.000 claims 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 싱귤레(singulett) 산소산화에 의해 식(Ⅱ)의 화합물을 산화시키고 중간 물질로서 얻어지는 15-과산화물 또는 14-과산화물을 환원시켜 식(Ⅰ)의 화합물을 생성하는 것을 특징으로 하는 밀베마이신 유도체의 제조방법과 그것을 활성성분으로 하는 살충제 조성물;(I)(Ⅱ)상기식에서 A는 또는 구조를 가지며 X는 -CH(OR1)- 또는 -CO- 이며, R1은 수소, 실릴그룹 또는 아실그룹이며 R2는 메틸, 에틸, 이소프로필 또는 2차-부틸임.
- 제1항에 있어서, 반응은 불활성 용매 내에서 온도가 -90°내지 +45℃의 범위이고, 정상압에서 감광제의 존재하에 가시광선을 사용하여 수행되는 것을 특징으로 하는 방법.
- 제2항에 있어서, 반응은 0°내지 +20℃ 범위의 온도로 수행되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 반응은 60 내지 500와트의 램프를 가진 방사기내에서 수행되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 반응단계는 NaBH4, LiAIH4또는 P(C6H5)3을 사용하여 수행되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 밀베마이신 D 또는 5-케토-밀베마이신 D의 싱귤렐 산소 산화와 환원에 의하여, A가 상기식과 같고, X가 -CH0H 또는 -CO- 이거나, R2가 이소프로필인 식(Ⅰ)의 일베마이신 유도체를 제조하는 것을 특징으로 하는 방법.
- 적합한 담체 및/또는 희석재와 함께 식(Ⅰ)의 화합물을 적어도 하나의 활성성분으로 포함하는 것을 특징으로 하는 살충제 조성물.
- 제7항에 있어서, 제1항에 따른 화합물을 적어도 한개를 포함하는 것을 특징으로 하는 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH5909/83-6 | 1983-11-02 | ||
| CH590983 | 1983-11-02 | ||
| CH473684 | 1984-10-02 | ||
| CH4736/84-3 | 1984-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850003894A true KR850003894A (ko) | 1985-06-29 |
Family
ID=25696163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840006869A KR850003894A (ko) | 1983-11-02 | 1984-11-02 | 밀베마이신 유도체의 제조방법과 그것을 활성성분으로 하는 살충제 조성물 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4582852A (ko) |
| EP (1) | EP0144285B1 (ko) |
| JP (1) | JPS60120880A (ko) |
| KR (1) | KR850003894A (ko) |
| AT (1) | ATE38230T1 (ko) |
| AU (1) | AU575871B2 (ko) |
| CA (1) | CA1257586A (ko) |
| DE (1) | DE3474825D1 (ko) |
| DK (1) | DK519984A (ko) |
| IL (1) | IL73384A (ko) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60126289A (ja) * | 1983-11-14 | 1985-07-05 | Sankyo Co Ltd | ミルベマイシン類の５−カ−ボネ−ト誘導体 |
| US4584314A (en) * | 1983-11-25 | 1986-04-22 | Ciba-Geigy Corporation | Lactone derivative, process for the preparation thereof, and use thereof in pest control |
| DK614084A (da) * | 1983-12-30 | 1985-07-01 | Ciba Geigy Ag | Milbemycim-derivater samt deres fremstilling og anvendelse |
| US4696922A (en) * | 1984-11-26 | 1987-09-29 | Ciba-Geigy Corporation | 5-azolylacetoxymilbemycins as ecto- and endoparasites |
| US4857509A (en) * | 1985-01-22 | 1989-08-15 | Ciba-Geigy Corporation | 13β-alkylmilbemycin derivatives for controlling parasites of animals and plants |
| US4666937A (en) * | 1985-03-04 | 1987-05-19 | Merck & Co., Inc. | Avermectin bioconversion products |
| AR243528A1 (es) * | 1986-12-11 | 1993-08-31 | Sankyo Co | Procedimiento para preparar compuestos de macrolida y un procedimiento para producir con los mismos una composicion parasiticida. |
| US5212322A (en) * | 1986-12-11 | 1993-05-18 | Sankyo Company, Limited | Macrolide compounds, their preparation and their use |
| EP0285561A3 (de) * | 1987-03-27 | 1989-10-25 | Ciba-Geigy Ag | Parasitizide und insektizide Milbemycin-Derivate |
| JPH0631246B2 (ja) * | 1988-02-02 | 1994-04-27 | 三共株式会社 | ５−オキソミルベマイシン誘導体の製造方法 |
| EP0524686A1 (en) * | 1991-07-23 | 1993-01-27 | Merck & Co. Inc. | A process for the 14a-hydroxylation of avermectin compounds |
| US5312753A (en) * | 1992-03-23 | 1994-05-17 | Merck & Co., Inc. | Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions |
| JP4373080B2 (ja) * | 2002-12-24 | 2009-11-25 | 三井化学アグロ株式会社 | ミルベマイシン類の精製法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201861A (en) * | 1977-10-03 | 1980-05-06 | Merck & Co., Inc. | Acyl derivatives of C-076 compounds |
| US4173571A (en) * | 1977-12-19 | 1979-11-06 | Merck & Co., Inc. | 13-Halo and 13-deoxy derivatives of C-076 compounds |
| US4328335A (en) * | 1979-08-13 | 1982-05-04 | Merck & Co., Inc. | Process for the interconversion of C-076 compounds |
| US4289760A (en) * | 1980-05-02 | 1981-09-15 | Merck & Co., Inc. | 23-Keto derivatives of C-076 compounds |
| US4469682A (en) * | 1983-01-28 | 1984-09-04 | Merck & Co., Inc. | Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use |
| US4584314A (en) * | 1983-11-25 | 1986-04-22 | Ciba-Geigy Corporation | Lactone derivative, process for the preparation thereof, and use thereof in pest control |
| DK614084A (da) * | 1983-12-30 | 1985-07-01 | Ciba Geigy Ag | Milbemycim-derivater samt deres fremstilling og anvendelse |
| EP0165900A3 (de) * | 1984-06-08 | 1986-05-28 | Ciba-Geigy Ag | Neue Lactone, Verfahren zu ihrer Herstellung und ihre Verwendung in der Schädlingsbekämpfung |
-
1984
- 1984-10-25 US US06/664,677 patent/US4582852A/en not_active Expired - Lifetime
- 1984-10-29 EP EP84810519A patent/EP0144285B1/de not_active Expired
- 1984-10-29 AT AT84810519T patent/ATE38230T1/de not_active IP Right Cessation
- 1984-10-29 DE DE8484810519T patent/DE3474825D1/de not_active Expired
- 1984-10-31 IL IL73384A patent/IL73384A/xx unknown
- 1984-10-31 CA CA000466670A patent/CA1257586A/en not_active Expired
- 1984-11-01 DK DK519984A patent/DK519984A/da not_active Application Discontinuation
- 1984-11-01 AU AU34907/84A patent/AU575871B2/en not_active Ceased
- 1984-11-01 JP JP59229065A patent/JPS60120880A/ja active Granted
- 1984-11-02 KR KR1019840006869A patent/KR850003894A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU575871B2 (en) | 1988-08-11 |
| IL73384A (en) | 1988-01-31 |
| DK519984A (da) | 1985-05-03 |
| EP0144285B1 (de) | 1988-10-26 |
| EP0144285A1 (de) | 1985-06-12 |
| JPS60120880A (ja) | 1985-06-28 |
| AU3490784A (en) | 1985-05-09 |
| DK519984D0 (da) | 1984-11-01 |
| DE3474825D1 (en) | 1988-12-01 |
| JPH0564154B2 (ko) | 1993-09-14 |
| CA1257586A (en) | 1989-07-18 |
| IL73384A0 (en) | 1985-01-31 |
| ATE38230T1 (de) | 1988-11-15 |
| US4582852A (en) | 1986-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |