KR850002833A - 젬-디아미노알칸 유도체 감미료 - Google Patents

젬-디아미노알칸 유도체 감미료 Download PDF

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KR850002833A
KR850002833A KR1019840002963A KR840002963A KR850002833A KR 850002833 A KR850002833 A KR 850002833A KR 1019840002963 A KR1019840002963 A KR 1019840002963A KR 840002963 A KR840002963 A KR 840002963A KR 850002833 A KR850002833 A KR 850002833A
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스테펀 버어랜더 마이클 (외 2)
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마아빈 이. 아이슨스타트
컴버랜드 팩킹 코오퍼레이션
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Abstract

내용 없음

Description

젬-디아미노알칸 유도체 감미료
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (32)

  1. 다음 일반식의 화합물:
    여기서 n은 0 또는 1이고, R은 저알킬, 저히드록시알킬 또는 저티오알킬이여, R´는 수소 또는 저알킬이고, R˝는 3-10 탄소원자의 분기알킬, 3-7 탄소원자의 시클로알킬, 1-5 저알킬기로 치환된 시클로알킬, 저알킬-시클로알킬, 디시클로알킬, 헤테로원자가 산소, 질소 또는 황이고 시클로알킬기는 4-7 탄소 원자의 것인 헤테로시클로알킬, 저알킬치환헤테로시클로알킬, 용융폴리시클로알킬, 페닐 또는 저알킬치환 페닐이다.
  2. 제1항에 있어서, 용융폴리시클로알킬은 노르보닐, 휀칠, 1-아다맨틸 또는 2-아다맨틸인 상기 화합물.
  3. 제1항에 있어서, 시클로알킬은 5-6 탄소원자인 상기 화합물.
  4. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 시클로펜틸인 상기 화합물.
  5. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 트리메틸 아세틸인 상기 화합물.
  6. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 노르보닐인 상기 화합물.
  7. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 2-메틸시클로헥실인 상기 화합물.
  8. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 디시클로프로필메틸인 상기 화합물.
  9. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 디메틸시클로펜틸인 상기 화합물.
  10. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 테트라메틸 시클로펜틸인 상기 화합물.
  11. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 디메틸시클로헤실인 상기 화합물.
  12. 제1항에 있어서, n=1, R은 메틸, R´는 수소 그리고 R˝는 t-부틸시클로헥실인 상기 화합물.
  13. 제1항에 있어서, n=1, R은 히드록시메틸, R´는 수소 그리고 R˝는 테트라메틸 시클로펜틸인 상기 화합물.
  14. 제1항에 있어서, n=1, R과 R´는 메틸 그리고 R˝는 시클로펜틸인 상기 화합물.
  15. 제1항의 화합물 유효량과 비독성담체로 이루어지는 것을 특징으로 하는 식용감미물질 조성물.
  16. 제1항의 화합물 유효량과 식용물질로 이루어지는 것을 특징으로 하는 식용감미 조성물.
  17. 제1항의 화합물 향증진 유효량과 비독성담체로 이루어지는 것을 특징으로 하는 식용물질의 향 증진 조성물.
  18. 제1항의 화합물 향증진 유효량과 식용물질로 이루어지는 것을 특징으로 하는 향증진식용조성물.
  19. 제1항의 화합물 향증진 유효 감미량을 식용물질에 첨가하는 것으로 이루어지는 식용물질 감미방법.
  20. 제1항의 화합물 향증진유효량을 식용물질에 첨가하는 것으로 이루어지는 식용물질의 향증진방법.
  21. 다음 일반식의 보호아미노산을,
    (여기서 n은 1 또는 2, X는 아민보호기 그리고 Y는 카르보닐 보호기이다)
    다음 일반식의 아미노산 유도체,
    (여기서 R은 저알킬, 저히드록시알킬 또는 저티오알킬이고 R´는 수소 또는 저알킬이며 Z는 수소 또는 카르복실 보호기이다)와 반응시켜 다음 일반식의 화합물
    을 생성하는 단계와, 보호기 Z를, 그것이 수소가 아닌 경우에는, 제거하여 다음 일반식의 화합물
    을 생성하는 단계와, 그리고 이 화합물을 다음 일반식의 해당하는 모노아실레이트젬-디아미노 알칸염
    (여기서 R, R´, n, X 및 Y는 상기와 같은 정의를 가지며 A는 음이온이다)으로 전환시키는 단계, 그리고 이 화합물을 일반식 R˝COC1의 화합물(여기서 R˝는 상기와 같은 정의를 갖는다)의 산염화물과 반응시켜서 다음 일반식의 해당하는 보호된 감미료 유도체
    를 생성하는 단계와, 보호기 X와 Y를 제거하는 단계로 이루어지는 다음 일반식의 화합물을 제조하는 방법.
    여기서 n은 0 또는 1이고, R은 저알킬, 저히드록시알킬 또는 저티오알킬이며, R´는 수소 또는 저알킬이고, R˝는 3-10 탄소원자의 분기알킬, 3-7 탄소원자의 시클로 알킬, 1-5 저알킬기로 치환된 시클로알킬, 저알킬-시클로알킬, 디시클로알킬, 헤테로원자가 산소, 질소 또는 황이고 시클로알킬기가 4-7 탄소원자의 것인 헤테로 시클로알킬, 저알킬-치환헤테로 시클로알킬, 용융폴리시클로알킬, 페닐 또는 저알킬-치환페닐이다.
  22. 제21항에 있어서, 카르복실산 유도체의 모노아실레이트 젬-디아미노알칸염으로의 전환은 커티우스(Curtius)전이 반응에 의하여 실행되는 것을 특징으로 하는 상기 화합물의 제조방법.
  23. 제21항에 있어서, 카르복실산 유도체의 모노아실레이트 젬-디아미노알칸염으로의 전환은 슈미트(Schmidt)전이반응에 의하여 달성되는 것을 특징으로 하는 상기 화합물의 제조방법.
  24. 제21항에 있어서, 카르복실산 유도체의 모노아실레이트 젬-디아미노알칸염으로의 전환은 처음에 카르복실산 유도체를 암모니아와의 축합반응에 의하여 해당하는 아미드로 전환시키고 다음에 아미드를 호프만(Hofmann)전이 반응에 의하여 젬-디아미노 알칸염으로 전한시킴으로써 실행되는 것을 특징으로 하는 상기 화합물의 제조방법.
  25. 다음 일반식의 아미노산 유도체
    (여기서 R은 저알킬, 저히드록시알킬 또는 저 티오-알킬이고 R´는 수소 또는 저알킬이며 Z는 카르복실 보호기이다)를 일반식 R˝COC1의 산염화물(R˝는 상기와 같은 정의를 갖는다)과 반응시켜 다음 일반식의 해당화합물
    를 생성하는 단계와, 보호기 Z를 제거시켜 다음 일반식의 해당하는 아실레이트 아미노산 유도체
    를 생성하는 단계, 이 화합물을 다음 일반식의 1차 아미드 유도체
    로 전환시키는 단계, 이와 같이 얻은 1차 아미드유도체를 전이 반응시켜 다음 일반식의 화합물
    (여기서 A는 음이온이다)을 생성하는 단계, 그리고 이와 같이 얻은 전이반응된 화합물을 다음 일반식의 브호된 아미노말론사 또는 아스파르트산 유도체
    (여기서 X는 아민 보호기이고, Y는 카르복실 보호기 그리고 n은 1 또는 2이다)와 축합반응시켜 다음 일반식의 X와 Y에 의하여 보호된 아민과 카르복실기를 갖는 해당하는 젬-디아미노알칸
    을 생성하는 단계, 그리고 보호기 X와 Y를 제거하는 단계로 이루어지는 다음 일반식의 화합물을 제조하는 방법
    여기서 n은 0 또는 1, R은 저알킬, 저히드록시 알킬 또는 저티오-알킬, R´는 수소 또는 저알킬, 그리고 R˝는 3-10 탄소원자인 분기알킬, 3-7 탄소원자인 시클로알킬, 1-5 저알킬기로 치환된 시클로알킬, 저알킬-시클로알킬, 디시클로알킬, 헤테로원자가 산소, 질소 또는 황이고 시클로알킬기가 4-7 탄소원자의 것인 헤테로시클로알킬, 저알킬-치환헤테로시클로알킬, 용융폴리시클로알킬, 페닐 또는 저알킬-치환페닐이다.
  26. 제25항에 있어서, 다음 일반식의 아민염
    이 다음 일반식의 아미노말론산 또는 아스파르트산의 환산유도체
    (여기서 W는 산소 또는 황이다)와 함께 최종 일반식의 해당 화합물을 형성하는 것을 특징으로 하는 상기 화합물의 제조방법.
  27. 화합물 2,2,5,5-테트라메틸시클로펜탄온.
  28. 화합물 1,2,2,5,5-펜타메틸시클로펜탄올.
  29. 화합물 1-메틸렌-2,2,5,5-테트라메틸시클로펜탄.
  30. 화합물 2,2,5,5-테트라메틸시클로펜틸메탄올.
  31. 화합물 2,2,5,5-테트라메틸시클로펜탄카르복실산.
  32. 제1항에 있어서, 생리적으로 허용되는 양이온 및 산 첨가염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840002963A 1983-06-13 1984-05-29 젬-디아미노알칸 유도체 감미료 KR910000406B1 (ko)

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US06/503,853 US4571345A (en) 1983-06-13 1983-06-13 1,1-Diaminoalkane derived sweeteners
US503853 1983-06-13

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692512A (en) * 1984-07-13 1987-09-08 The Procter & Gamble Company Alpha-L-aspartyl-D-phenylglycine esters and amides useful as high intensity sweeteners
US4654219A (en) * 1984-12-27 1987-03-31 General Foods Corporation L-aminodicarboxylic-(O-cycloalkyl)-L-aminocarboxylate alkyl ester sweeteners
EP0196461A3 (en) * 1985-03-01 1987-04-22 Kyowa Hakko Kogyo Co., Ltd. Cyclopentane derivatives
US4619782A (en) * 1985-04-15 1986-10-28 General Foods Corporation L-aminodicarboxylic acid gem-diamines
US4636396A (en) * 1985-04-15 1987-01-13 General Foods Corporation Foodstuff with L-aminodicarboxylic acid gem-diamines
US4666729A (en) * 1985-05-24 1987-05-19 General Foods Corporation Sweetening with L-aminodicarboxylic acid amides of alkoxyalkylamines
US4654439A (en) * 1985-05-24 1987-03-31 General Foods Corporation L-aminodicarboxylic acid amides of alkoxyalkylamines
IL80577A0 (en) * 1985-11-27 1987-02-27 Schering Ag Process for the preparation of cyclopentanecarboxylic acid derivatives
US4692513A (en) * 1985-12-20 1987-09-08 The Procter & Gamble Company Alpha-L-aspartyl-D-heteroaromatic-substituted glycine esters and amides useful as high intensity sweeteners
DE3617605A1 (de) * 1986-05-23 1987-11-26 Schering Ag Verfahren zur herstellung von diaminoalkan-derivaten
FR2630304B1 (fr) * 1988-04-22 1990-08-31 Bernard Lyon I Universite Clau Derives n-hydrocarbones des acides aspartique et glutamique alpha-monoamides utiles comme agents edulcorants
IT1228451B (it) * 1989-02-22 1991-06-19 Sclavo S P A Siena Nuovi derivati diamminici geminali e loro impiego nelle sintesi di peptidi retro-inversi
WO1996028413A1 (en) * 1995-03-16 1996-09-19 Hoechst Celanese Corporation Synthesis of amidocarboxylic acid derivatives
NZ545747A (en) * 2003-08-06 2010-06-25 Senomyx Inc T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
US9101160B2 (en) * 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20070116839A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition With C-Reactive Protein Reducing Substance and Compositions Sweetened Therewith
US8945652B2 (en) * 2005-11-23 2015-02-03 The Coca-Cola Company High-potency sweetener for weight management and compositions sweetened therewith
US8377491B2 (en) * 2005-11-23 2013-02-19 The Coca-Cola Company High-potency sweetener composition with vitamin and compositions sweetened therewith
US8940350B2 (en) * 2005-11-23 2015-01-27 The Coca-Cola Company Cereal compositions comprising high-potency sweeteners
US20070116829A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Pharmaceutical Composition with High-Potency Sweetener
US8435587B2 (en) * 2005-11-23 2013-05-07 The Coca-Cola Company High-potency sweetener composition with long-chain primary aliphatic saturated alcohol and compositions sweetened therewith
US20070116800A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company Chewing Gum with High-Potency Sweetener
US8435588B2 (en) * 2005-11-23 2013-05-07 The Coca-Cola Company High-potency sweetener composition with an anti-inflammatory agent and compositions sweetened therewith
US8367138B2 (en) * 2005-11-23 2013-02-05 The Coca-Cola Company Dairy composition with high-potency sweetener
EP1971228A1 (en) * 2005-11-23 2008-09-24 The Coca-Cola Company Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
US8940351B2 (en) * 2005-11-23 2015-01-27 The Coca-Cola Company Baked goods comprising high-potency sweetener
US20070116833A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition with Calcium and Compositions Sweetened Therewith
US8524303B2 (en) * 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with phytosterol and compositions sweetened therewith
US8524304B2 (en) * 2005-11-23 2013-09-03 The Coca-Cola Company High-potency sweetener composition with probiotics/prebiotics and compositions sweetened therewith
US8512789B2 (en) * 2005-11-23 2013-08-20 The Coca-Cola Company High-potency sweetener composition with dietary fiber and compositions sweetened therewith
KR101387563B1 (ko) 2006-04-21 2014-04-25 세노믹스, 인코포레이티드 고효능의 조미용 향료를 포함하는 식품 조성물 및 이의 제조 방법
US8017168B2 (en) * 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US7632792B2 (en) * 2007-11-16 2009-12-15 International Flavors & Fragrances Inc. Methyl cyclohexane carboxylates and their use in perfume compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492131A (en) * 1966-04-18 1970-01-27 Searle & Co Peptide sweetening agents
US4338346A (en) * 1978-12-21 1982-07-06 The Procter & Gamble Company Non-nutritive sweetener
US4411925A (en) * 1980-01-21 1983-10-25 Pfizer Inc. Branched amides of L-aspartyl-d-amino acid dipeptides
US4399163A (en) * 1980-11-05 1983-08-16 Pfizer Inc. Branched amides of L-aspartyl-D-amino acid dipeptides
US4423029A (en) * 1981-06-25 1983-12-27 The Procter & Gamble Company (S)-3-Amino-4-[(S,S)-1-(1-hydroxyethyl)alkyl amino]-4-oxo-butyric acid compounds suitable as non-nutritive sweetners

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AU567944B2 (en) 1987-12-10
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ES8704879A1 (es) 1987-04-16
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EP0242896A2 (en) 1987-10-28
CA1221683A (en) 1987-05-12
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EP0128654A3 (en) 1985-05-29
US4571345A (en) 1986-02-18
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