DK372083A - Fremgangsmaade til fremstilling af peptidderivater, der er inhibitorer overfor proteasesyrer - Google Patents

Fremgangsmaade til fremstilling af peptidderivater, der er inhibitorer overfor proteasesyrer Download PDF

Info

Publication number
DK372083A
DK372083A DK372083A DK372083A DK372083A DK 372083 A DK372083 A DK 372083A DK 372083 A DK372083 A DK 372083A DK 372083 A DK372083 A DK 372083A DK 372083 A DK372083 A DK 372083A
Authority
DK
Denmark
Prior art keywords
preparation
peptide derivatives
group
formula
proteic
Prior art date
Application number
DK372083A
Other languages
English (en)
Other versions
DK372083D0 (da
Inventor
Catherine Cazaubon
Joseph Diaz
Jean-Pierre Gagnol
Remy Guegan
Bernard Castro
Genevieve Evin
Pierre Corvol
Original Assignee
Sanofi Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa
Publication of DK372083D0 publication Critical patent/DK372083D0/da
Publication of DK372083A publication Critical patent/DK372083A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK372083A 1982-08-17 1983-08-15 Fremgangsmaade til fremstilling af peptidderivater, der er inhibitorer overfor proteasesyrer DK372083A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8214219A FR2531951A1 (fr) 1982-08-17 1982-08-17 Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent

Publications (2)

Publication Number Publication Date
DK372083D0 DK372083D0 (da) 1983-08-15
DK372083A true DK372083A (da) 1984-02-18

Family

ID=9276914

Family Applications (1)

Application Number Title Priority Date Filing Date
DK372083A DK372083A (da) 1982-08-17 1983-08-15 Fremgangsmaade til fremstilling af peptidderivater, der er inhibitorer overfor proteasesyrer

Country Status (13)

Country Link
US (1) US4481192A (da)
EP (1) EP0104964B1 (da)
JP (1) JPH0680076B2 (da)
AT (1) ATE28078T1 (da)
AU (1) AU563230B2 (da)
CA (1) CA1245632A (da)
DE (1) DE3372289D1 (da)
DK (1) DK372083A (da)
ES (1) ES8405365A1 (da)
FR (1) FR2531951A1 (da)
GR (1) GR79635B (da)
NZ (1) NZ205296A (da)
ZA (1) ZA835962B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1039267B (de) * 1953-12-19 1958-09-18 Schenk Bau G M B H Vorrichtung zum Erzeugen gerichteter Schwingungen mit umlaufender Unwucht
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
DE3381565D1 (de) * 1982-12-27 1990-06-21 Merck & Co Inc Reninhemmende tripeptide.
DK110285A (da) * 1984-03-12 1985-09-13 Pfizer Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater
FR2564844A1 (fr) * 1984-05-25 1985-11-29 Sanofi Sa Nouveaux peptides derives de la statine, procede d'obtention et compositions pharmaceutiques les contenant
FR2565584B1 (fr) * 1984-06-06 1986-10-17 Sanofi Sa Derives d'acide heptanoique, leur procede de preparation ainsi que leur utilisation
FR2577226B1 (fr) * 1985-02-12 1990-06-15 Sanofi Sa Analogues de pepstatine inhibiteurs de la renine et des proteases acides
FR2577225B1 (fr) * 1985-02-12 1987-08-28 Sanofi Sa Derives peptidiques inhibiteurs de la renine et des proteases acides
CA1286846C (en) * 1985-02-12 1991-07-23 Catherine Cazaubon Peptide derivatives which inhibit renin and acid proteases
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4777286A (en) * 1985-06-18 1988-10-11 The Upjohn Company Certain aryl or hetero-hydroxamic acid esters useful as renin inhibitors
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
US4906613A (en) * 1985-11-05 1990-03-06 Schering Corporation Antiglaucoma compositions and methods
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
FR2646353B1 (fr) * 1989-04-27 1994-02-25 Sanofi Utili sation de peptides contenant de la statine pour la preparation de medicaments utiles pour le traitement des maladies virales
US5688770A (en) * 1989-12-14 1997-11-18 Schering Corporation Antiglaucoma compositions and methods
JPH06505474A (ja) * 1991-01-31 1994-06-23 アボツト・ラボラトリーズ エンドセリン転換酵素阻害剤
AU7714594A (en) * 1993-08-13 1995-03-14 Merck & Co., Inc. Substituted ketone derivatives as inhibitors of interleukin-1beta converting enzyme
WO1996012738A2 (en) * 1994-10-20 1996-05-02 Nzym, Inc. Pepstatin-derivatives for the treatment and detection of fungal infections
US5798442A (en) * 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
EP2113510A1 (en) * 2008-04-30 2009-11-04 Freie Universität Berlin Pepstatin A derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840516A (en) * 1969-06-13 1974-10-08 Microbial Chem Res Found Biologically active substance,pepstatin and production processes thereof
JPS5022116B1 (da) * 1970-04-28 1975-07-28
DK132899C (da) * 1972-04-07 1976-07-26 Takeda Chemical Industries Ltd Fremgangsmade til fremstilling af de proteaseinhiberende stoffer pepsinostreptiner eller salte deraf
DE2506601C3 (de) * 1974-02-28 1980-12-11 Sanraku-Ocean Co., Ltd., Tokio Tetrapeptide und Verfahren zu ihrer Herstellung
JPS52108925A (en) * 1976-03-09 1977-09-12 Sumitomo Chem Co Ltd Protease inhibitor
JPS5938220B2 (ja) * 1976-12-16 1984-09-14 住友化学工業株式会社 ペプタイド
JPS54163826A (en) * 1978-06-12 1979-12-26 Sumitomo Chemical Co Hypertension treating agent
JPS56147718A (en) * 1980-04-16 1981-11-16 Sumitomo Chem Co Ltd Acidic protease inhibitor and antiulcerative composed thereof
JPS56164153A (en) * 1980-05-20 1981-12-17 Eisai Co Ltd Novel desacylvalypepsidin derivative and its preparation

Also Published As

Publication number Publication date
EP0104964A1 (fr) 1984-04-04
EP0104964B1 (fr) 1987-07-01
ATE28078T1 (de) 1987-07-15
JPS5989649A (ja) 1984-05-23
ES525553A0 (es) 1984-06-01
US4481192A (en) 1984-11-06
DE3372289D1 (en) 1987-08-06
CA1245632A (fr) 1988-11-29
ES8405365A1 (es) 1984-06-01
AU563230B2 (en) 1987-07-02
FR2531951A1 (fr) 1984-02-24
DK372083D0 (da) 1983-08-15
NZ205296A (en) 1987-10-30
JPH0680076B2 (ja) 1994-10-12
AU1787483A (en) 1984-02-23
FR2531951B1 (da) 1985-01-18
GR79635B (da) 1984-10-31
ZA835962B (en) 1984-10-31

Similar Documents

Publication Publication Date Title
DK372083D0 (da) Fremgangsmade til fremstilling af peptidderivater, der er inhibitorer overfor proteasesyrer
FR2281162A1 (fr) Aminoacides n-acyles et derives d'acides amines n-acyles comme agents gelifiants
RU94046295A (ru) L-аспартил-d- альфа -аминоалканоил-(s)-n-d-алкилбензиламиды, используемые в качестве искусственных подслащивающих агентов, пищевой состав, способ подслащивания пищевого состава
DE3166150D1 (en) N-(vinblastinoyl-23) derivatives of amino acids and peptides and their preparation
DE3784799T2 (de) Malonsaeurederivate und ihre synthesemethoden.
HU913331D0 (en) Peptides and process for their production
IL104716A (en) 7-1-oxo-2- (substituted mercapto)-3- phenylpropyl) amino| octahydro-6-pyrido £2, 1-a| benzazepine- 4-carboxylic acid derivatives and analogs, their preparation and pharmaceutical compositions containing them for inhibiting enkephalinase and ace
ES2091359T3 (es) Nuevo compuesto peptidico y un procedimiento para su preparacion.
RU96104348A (ru) Профилактика спида
HU896606D0 (en) Process for the preparation of aminoacid derivatives inhibiting enzymes and pharmaceutical compositions thereof
DK0752425T3 (da) Peptidligander for den konstante region på immunoglobuliner
ES548052A0 (es) Procedimiento para preparar peptidos
IL70663A0 (en) Novel condensed pyrrole derivatives,processes for their preparation and pharmaceutical compositions containing the same
HU896772D0 (en) Process for preparation of 34des(acetyl-glucosaminyl)-4-desoci-teicoplanin-c63-amide-derivatives
DE69102069D1 (de) 5-aminosalicylsäurederivate zur therapie chronisch entzündlicher baucherkrankungen.
SE8306112L (sv) Biologiskt aktiva peptider
JPS5645449A (en) Novel peptide, its pharmaceutically acceptable salt and preparation of the same
ATE27822T1 (de) Hexapeptid, verfahren zur herstellung und pharmazeutische zusammensetzungen hieraus.
TH15712A (th) กรรมวิธีสำหรับผลิตอะมิโนแอลคิลกัวนิดีน
ES2054208T3 (es) Nuevos derivados gem-diaminicos y su empleo en la sintesis de peptidos retro-inversos.
KR830004213A (ko) 생물학적 활성을 가지는 펲타이드의 제조방법
JPS5782352A (en) Glutamine derivative
TH27915B (th) การปรับปรุงความสามารถที่จะทนทานได้ของกรด(สูตร)- อะมิโนที่ออกฤทธิ์ทางเภสัชกรรม
TH21704B (th) เพพไทด์ชนิดใหม่ที่มีผลปรับภูมิคุ้มกัน
JPS5782353A (en) Glutamine derivative

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment