KR830004213A - 생물학적 활성을 가지는 펲타이드의 제조방법 - Google Patents
생물학적 활성을 가지는 펲타이드의 제조방법 Download PDFInfo
- Publication number
- KR830004213A KR830004213A KR1019800003664A KR800003664A KR830004213A KR 830004213 A KR830004213 A KR 830004213A KR 1019800003664 A KR1019800003664 A KR 1019800003664A KR 800003664 A KR800003664 A KR 800003664A KR 830004213 A KR830004213 A KR 830004213A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- amino acid
- amino
- protecting group
- groups
- Prior art date
Links
- 230000004071 biological effect Effects 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- -1 2,4-dichlorobenzyl Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 4
- 150000008575 L-amino acids Chemical group 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 150000008574 D-amino acids Chemical group 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000003862 amino acid derivatives Chemical class 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Chemical group O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 펩타이드 결합에 필요한 말단 카복실그룹이나 말단아미노 그룹을 활성화시키고 나머지 반응성 그룹은 보호하여서 후술하는 순서(順序)의 아미노산이나 아미노산 유도체 및 또는 이러한 순서의 아미노산이나 이들의 유도체를 함유하는 펩타이드 분획을 축합시켜 목적하는 구조식(I)의 화합물과 이들의 약학적으로 무독한 염을 제조하는 방법.상기 구조식(Ⅰ)에서X는 수소이거나 아실형보호그룹, 방향족 우레탄형보호그룹, 알킬형 보호그룹, 알킬형 보호그룹, 지방족 우레탄 보호그룹중에서 선택한 N-말단 보호그룹이며 이와는 달리 천연의 L-아미노산기이거나 두개의 아미노그룹이 전술한 N-말단 보호그룹중의 어느 것으로나 치환된 두 개의 천연 L-아미노산으로 이루어진 디펩타이드이며,Y는 수소이거나 타이로신의 하이드록실기에 대한 테트라 하이드로피라닐, 메틸, 3급-부틸, 트리틸, 벤질, 2,4-디클로로벤질, 벤질옥시카보닐, 2-브로모벤질옥시카보닐, 3급-부틸옥시카보닐중에서 선택된 보호그룹 또는 저급아실,A는 측쇄가 저급알킬이나 저급티오알킬그룹으로 이루어진 D-아미노산잔기이며,B는 중성 L-아미노산 잔기, 글라이신잔기나 N-메틸화된 아미노산 잔기,C는 존재하거나 부재하며 존재하는 경우에는 아미노산기나 디- 또는 트리-펩타이드로서 아미노산은 염기성이나 산성이 아닌 것을 전제로 하여 L이나 D 배열인 α-아미노, α-이미노, β-이미노나 N-메틸아미노이며, 하이드록시 아미노산인 경우에는 하이드록시기가 유리상태이거나 Y항에서 정의된 보호그룹중의 하나로 보호되며 언급한 디-또는 트리-펩타이드는 C항에서 정의한 아미노산으로 이루어진다.W는 OH,OR,NH2,NR2,NHNHR'이며 이때 R는 치환되거나 치환되지 않은 C1-10의 직쇄나 측쇄의 알킬-C1-10사이클로알킬C6-8아랄킬, 편리하게는 페닐, 벤질이나 페닐에틸이며,R1는 수소-C1-10의 직쇄나 측쇄알킬, 사이클로알킬 또는 C6-8아랄킬-C2-8알케닐-치환되지 않거나 하이드록시, 아미노, 할로겐 원소나 C1-4안콕시로 치환된 C1-16의 직쇄, 측쇄, 지환족 아실형그룹,-치환되지 않거나 하이드록시, 아미노, 할로겐 원소나 C1-4알콕시로 치환된 방향족 아실형그룹 측쇄 그룹이 있는 직쇄 또는 C3-11의 지환족 우레탄형 그룹-방향족 우레탄형의 그룹이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019800003664A KR850001157B1 (ko) | 1980-09-18 | 1980-09-18 | 펩티드의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019800003664A KR850001157B1 (ko) | 1980-09-18 | 1980-09-18 | 펩티드의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830004213A true KR830004213A (ko) | 1983-07-06 |
| KR850001157B1 KR850001157B1 (ko) | 1985-08-16 |
Family
ID=19217746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800003664A KR850001157B1 (ko) | 1980-09-18 | 1980-09-18 | 펩티드의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR850001157B1 (ko) |
-
1980
- 1980-09-18 KR KR1019800003664A patent/KR850001157B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR850001157B1 (ko) | 1985-08-16 |
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| E701 | Decision to grant or registration of patent right |