ATE28078T1 - Peptide derivate, inhibitor von saeureproteasen, verfahren zu deren herstellung. - Google Patents

Peptide derivate, inhibitor von saeureproteasen, verfahren zu deren herstellung.

Info

Publication number
ATE28078T1
ATE28078T1 AT83401641T AT83401641T ATE28078T1 AT E28078 T1 ATE28078 T1 AT E28078T1 AT 83401641 T AT83401641 T AT 83401641T AT 83401641 T AT83401641 T AT 83401641T AT E28078 T1 ATE28078 T1 AT E28078T1
Authority
AT
Austria
Prior art keywords
peptide derivatives
group
formula
production
statyl2
Prior art date
Application number
AT83401641T
Other languages
English (en)
Inventor
Catherine Cazaubon
Joseph Diaz
Jean-Pierre Gagnol
Remy Guegan
Bernard Castro
Pierre Corvol
Genevieve Evin
Original Assignee
Sanofi Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Inst Nat Sante Rech Med filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE28078T1 publication Critical patent/ATE28078T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT83401641T 1982-08-17 1983-08-10 Peptide derivate, inhibitor von saeureproteasen, verfahren zu deren herstellung. ATE28078T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8214219A FR2531951A1 (fr) 1982-08-17 1982-08-17 Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
EP83401641A EP0104964B1 (de) 1982-08-17 1983-08-10 Peptide Derivate, Inhibitor von Säureproteasen, Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
ATE28078T1 true ATE28078T1 (de) 1987-07-15

Family

ID=9276914

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83401641T ATE28078T1 (de) 1982-08-17 1983-08-10 Peptide derivate, inhibitor von saeureproteasen, verfahren zu deren herstellung.

Country Status (13)

Country Link
US (1) US4481192A (de)
EP (1) EP0104964B1 (de)
JP (1) JPH0680076B2 (de)
AT (1) ATE28078T1 (de)
AU (1) AU563230B2 (de)
CA (1) CA1245632A (de)
DE (1) DE3372289D1 (de)
DK (1) DK372083A (de)
ES (1) ES8405365A1 (de)
FR (1) FR2531951A1 (de)
GR (1) GR79635B (de)
NZ (1) NZ205296A (de)
ZA (1) ZA835962B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1039267B (de) * 1953-12-19 1958-09-18 Schenk Bau G M B H Vorrichtung zum Erzeugen gerichteter Schwingungen mit umlaufender Unwucht
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
DE3381565D1 (de) * 1982-12-27 1990-06-21 Merck & Co Inc Reninhemmende tripeptide.
FI850948L (fi) * 1984-03-12 1985-09-13 Pfizer Renin inhibitorer som innehaoller statin eller dess derivat.
FR2564844A1 (fr) * 1984-05-25 1985-11-29 Sanofi Sa Nouveaux peptides derives de la statine, procede d'obtention et compositions pharmaceutiques les contenant
FR2565584B1 (fr) * 1984-06-06 1986-10-17 Sanofi Sa Derives d'acide heptanoique, leur procede de preparation ainsi que leur utilisation
CA1286846C (en) * 1985-02-12 1991-07-23 Catherine Cazaubon Peptide derivatives which inhibit renin and acid proteases
FR2577226B1 (fr) * 1985-02-12 1990-06-15 Sanofi Sa Analogues de pepstatine inhibiteurs de la renine et des proteases acides
FR2577225B1 (fr) * 1985-02-12 1987-08-28 Sanofi Sa Derives peptidiques inhibiteurs de la renine et des proteases acides
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4777286A (en) * 1985-06-18 1988-10-11 The Upjohn Company Certain aryl or hetero-hydroxamic acid esters useful as renin inhibitors
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
US4906613A (en) * 1985-11-05 1990-03-06 Schering Corporation Antiglaucoma compositions and methods
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
FR2646353B1 (fr) * 1989-04-27 1994-02-25 Sanofi Utili sation de peptides contenant de la statine pour la preparation de medicaments utiles pour le traitement des maladies virales
US5688770A (en) * 1989-12-14 1997-11-18 Schering Corporation Antiglaucoma compositions and methods
EP0569487A1 (de) * 1991-01-31 1993-11-18 Abbott Laboratories Endothelin konvertierende enzyminhibitoren
AU7714594A (en) * 1993-08-13 1995-03-14 Merck & Co., Inc. Substituted ketone derivatives as inhibitors of interleukin-1beta converting enzyme
WO1996012738A2 (en) * 1994-10-20 1996-05-02 Nzym, Inc. Pepstatin-derivatives for the treatment and detection of fungal infections
US5798442A (en) * 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
EP2113510A1 (de) * 2008-04-30 2009-11-04 Freie Universität Berlin Pepstatin-A-Derivate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840516A (en) * 1969-06-13 1974-10-08 Microbial Chem Res Found Biologically active substance,pepstatin and production processes thereof
JPS5022116B1 (de) * 1970-04-28 1975-07-28
DK132899C (da) * 1972-04-07 1976-07-26 Takeda Chemical Industries Ltd Fremgangsmade til fremstilling af de proteaseinhiberende stoffer pepsinostreptiner eller salte deraf
DE2506601C3 (de) * 1974-02-28 1980-12-11 Sanraku-Ocean Co., Ltd., Tokio Tetrapeptide und Verfahren zu ihrer Herstellung
JPS52108925A (en) * 1976-03-09 1977-09-12 Sumitomo Chem Co Ltd Protease inhibitor
JPS5938220B2 (ja) * 1976-12-16 1984-09-14 住友化学工業株式会社 ペプタイド
JPS54163826A (en) * 1978-06-12 1979-12-26 Sumitomo Chemical Co Hypertension treating agent
JPS56147718A (en) * 1980-04-16 1981-11-16 Sumitomo Chem Co Ltd Acidic protease inhibitor and antiulcerative composed thereof
JPS56164153A (en) * 1980-05-20 1981-12-17 Eisai Co Ltd Novel desacylvalypepsidin derivative and its preparation

Also Published As

Publication number Publication date
JPS5989649A (ja) 1984-05-23
DK372083D0 (da) 1983-08-15
AU1787483A (en) 1984-02-23
ES525553A0 (es) 1984-06-01
DK372083A (da) 1984-02-18
EP0104964B1 (de) 1987-07-01
FR2531951A1 (fr) 1984-02-24
JPH0680076B2 (ja) 1994-10-12
EP0104964A1 (de) 1984-04-04
GR79635B (de) 1984-10-31
DE3372289D1 (en) 1987-08-06
CA1245632A (fr) 1988-11-29
US4481192A (en) 1984-11-06
ES8405365A1 (es) 1984-06-01
NZ205296A (en) 1987-10-30
ZA835962B (en) 1984-10-31
AU563230B2 (en) 1987-07-02
FR2531951B1 (de) 1985-01-18

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