KR850002276A - Spf-100의 제조방법 - Google Patents
Spf-100의 제조방법 Download PDFInfo
- Publication number
- KR850002276A KR850002276A KR1019840004559A KR840004559A KR850002276A KR 850002276 A KR850002276 A KR 850002276A KR 1019840004559 A KR1019840004559 A KR 1019840004559A KR 840004559 A KR840004559 A KR 840004559A KR 850002276 A KR850002276 A KR 850002276A
- Authority
- KR
- South Korea
- Prior art keywords
- spf
- reaction
- absorption spectrum
- insoluble
- aqueous solution
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000862 absorption spectrum Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims 1
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 claims 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 229960004853 betadex Drugs 0.000 claims 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 238000000921 elemental analysis Methods 0.000 claims 1
- 238000002523 gelfiltration Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052750 molybdenum Inorganic materials 0.000 claims 1
- 239000011733 molybdenum Substances 0.000 claims 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N3/00—Spore forming or isolating processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 SPF－100의 0.1％ 수용액의 자외선 흡수 스펙트럼이고, 제2도는 SPF－100의 적외선 흡수 스펙트럼.
Claims (4)
- 다음의 물리화학적 성질을 갖는 SPF－100으로 불리워지는 물질.(1) 원소분석:C;46.42∼43.69％, H; 5.94∼4.85％ 및 N;11.42∼9.50％.(2) 분자량 : 겔 여과에 의해 결정된 대략 500 내지 25000.(3) 분해점 : 160℃에서 갈색으로 변하고, 200℃에서 검은색으로 변하고 분해된다.(4) 고유광 회전도 :＝＋45.0°(C＝1.00)(5) 자외선 흡수 스펙트럼 : 제1도는 0.1％의 수용액의 자외선 흡수 스펙트럼을 보여주고, 257,265,280, 287 및 325㎜에서 흡수에 의해 특징된다.(6) 적외선 흡수 스펙트럼 : 제2도는 적외선 흡수 스팩드럼을 보여준다.(7) 용매에 대한 용해도 : 물에 녹고, 메탄올 및 에탄올에 부분적으로 녹고, n－부탄올, 이소부탄올, n－프로판올, n－헥산, 클로로포름, 아세톤, 메틸이소부틸케톤 및 에틸에테르를 포함하는 용매에 의한 거의 녹지 않거나 또는 녹지 않는다.(8) 산도 : 1.0％ 수용액의 PH값은 6.5이다.(9) 형태 : 연노랑 분말.(10) 색반응 : 닌히드린 반응;＋, 뷰레트 반응;＋, 몰리취 반응;－, 디스췌 반응;－, 안트론 반응;－ 및, 황산시스테인 반응;－.(11) 안정도 : L－시스테인, 디티오트레이톨(DTT), 글리세롤, 알부민, 글로블린, α－ 및 β－시클로덱스트린, (NH4)2SO4, 보통염 등을 가하여 안정화될 수 있다.
- 제1항에 있어서, SPF－1 및 SPF－2로 분류됨을 특징으로 하는 SPF－100으로 불리워지는 물질.
- 연쇄상구균은 배양하고, 배양액으로부터 SPF－100으로 불리워지는 물질을 회수함을 특징으로 하는 SPF－100의 제조방법.
- 제3항에 있어서, 한 종양물질 SPF－100을 생산하는 연쇄상구균의 박테리아를 배양하는 과정동안 배양액에 페니실린 또는 관련된 물질을 가함을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58-139384 | 1983-08-01 | ||
| JP58139385A JPS6030689A (ja) | 1983-08-01 | 1983-08-01 | 生理活性物質ｓｐｆ−１及びその製法 |
| JP13938483A JPS6030677A (ja) | 1983-08-01 | 1983-08-01 | ストレプトコツカス属細菌の培養法 |
| JP58-139385 | 1983-08-01 | ||
| JP59072866A JPS60218324A (ja) | 1984-04-13 | 1984-04-13 | 生理活性物質ｓｐｆ−２及びその製法 |
| JP59072865A JPS60218323A (ja) | 1984-04-13 | 1984-04-13 | 抗腫瘍性物質ｓｐｆ―１０００及びその製法 |
| JP59-72866 | 1984-04-13 | ||
| JP59-72865 | 1984-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850002276A true KR850002276A (ko) | 1985-05-10 |
Family
ID=27465515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840004559A KR850002276A (ko) | 1983-08-01 | 1984-07-31 | Spf-100의 제조방법 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4656037A (ko) |
| KR (1) | KR850002276A (ko) |
| CA (1) | CA1237085A (ko) |
| CH (1) | CH663033A5 (ko) |
| DE (1) | DE3428017A1 (ko) |
| FR (1) | FR2550223B1 (ko) |
| GB (1) | GB2146028B (ko) |
| NL (1) | NL8402388A (ko) |
| SE (1) | SE461532B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0405569A1 (de) * | 1989-06-30 | 1991-01-02 | Cernitin S.A. | Produkt mit antimikrobieller Wirksamkeit, Verfahren zu dessen Isolierung aus dem Kulturmedium von Streptokokkus faecium und pharmazeutisches Präparat, enthaltend dieses Produkt mit antimikrobieller Wirksamkeit |
| WO1992009627A1 (fr) * | 1990-11-30 | 1992-06-11 | Asahi Glass Company Ltd. | Peptide ayant le pouvoir d'inhiber l'infiltration des cellules cancereuses, composite a base de ce peptide et inhibiteur de la metastase du cancer |
| WO2002062983A1 (fr) * | 2001-02-08 | 2002-08-15 | Six Forest Bio-Science Institute Limited | Levure faisant preuve d'une activite immunoregulatrice des lymphocytes t, son procede de preparation et ses applications |
| WO2002062981A1 (fr) * | 2001-02-08 | 2002-08-15 | Six Forest Bio-Science Institute Limited | Immunoregulateur humain de levure et son procede de preparation |
| WO2002062985A1 (fr) * | 2001-02-08 | 2002-08-15 | Six Forest Bio-Science Institute Limited | Levure faisant preuve d'un activite immunoregulatrice cellulaire nk, son procede de preparation et ses applications |
| CN104151137B (zh) * | 2014-08-08 | 2016-01-27 | 洪泽县恒泰科工贸有限公司 | 高压常压双塔精馏分离正丁醇和mibk共沸物系的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5632492A (en) * | 1979-08-28 | 1981-04-01 | Mitsui Toatsu Chem Inc | Antitumor active substance, its preparation and pharmaceutical |
| JPS5927833A (ja) * | 1982-08-06 | 1984-02-14 | Advance Res & Dev Co Ltd | コレステロール乃至トリグリセリド低下剤 |
-
1984
- 1984-07-20 CA CA000459394A patent/CA1237085A/en not_active Expired
- 1984-07-23 GB GB08418745A patent/GB2146028B/en not_active Expired
- 1984-07-30 CH CH3684/84A patent/CH663033A5/fr not_active IP Right Cessation
- 1984-07-30 DE DE19843428017 patent/DE3428017A1/de not_active Withdrawn
- 1984-07-31 SE SE8403914A patent/SE461532B/sv not_active IP Right Cessation
- 1984-07-31 FR FR8412119A patent/FR2550223B1/fr not_active Expired
- 1984-07-31 KR KR1019840004559A patent/KR850002276A/ko not_active Application Discontinuation
- 1984-07-31 NL NL8402388A patent/NL8402388A/nl not_active Application Discontinuation
-
1985
- 1985-06-19 US US06/746,514 patent/US4656037A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CH663033A5 (fr) | 1987-11-13 |
| FR2550223B1 (fr) | 1988-09-30 |
| FR2550223A1 (fr) | 1985-02-08 |
| CA1237085A (en) | 1988-05-24 |
| GB2146028B (en) | 1987-06-10 |
| GB2146028A (en) | 1985-04-11 |
| NL8402388A (nl) | 1985-03-01 |
| DE3428017A1 (de) | 1985-03-28 |
| GB8418745D0 (en) | 1984-08-30 |
| US4656037A (en) | 1987-04-07 |
| SE461532B (sv) | 1990-02-26 |
| SE8403914D0 (sv) | 1984-07-31 |
| SE8403914L (sv) | 1985-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |