KR850000468A - 사이클릭 펩타이드의 제조방법 - Google Patents

사이클릭 펩타이드의 제조방법 Download PDF

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Publication number
KR850000468A
KR850000468A KR1019840000444A KR840000444A KR850000468A KR 850000468 A KR850000468 A KR 850000468A KR 1019840000444 A KR1019840000444 A KR 1019840000444A KR 840000444 A KR840000444 A KR 840000444A KR 850000468 A KR850000468 A KR 850000468A
Authority
KR
South Korea
Prior art keywords
formula
preparing
iii
compound
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019840000444A
Other languages
English (en)
Korean (ko)
Inventor
프레드리히 액셀 (외 4)
Original Assignee
하인리히 벡커 베른하르트 벡크
훽스트 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 하인리히 벡커 베른하르트 벡크, 훽스트 아크티엔 게젤샤프트 filed Critical 하인리히 벡커 베른하르트 벡크
Publication of KR850000468A publication Critical patent/KR850000468A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
KR1019840000444A 1983-02-02 1984-01-31 사이클릭 펩타이드의 제조방법 Ceased KR850000468A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833303345 DE3303345A1 (de) 1983-02-02 1983-02-02 Cyclische peptide mit somatostatin-wirkung
DEP3303345.5 1983-02-02

Publications (1)

Publication Number Publication Date
KR850000468A true KR850000468A (ko) 1985-02-27

Family

ID=6189751

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840000444A Ceased KR850000468A (ko) 1983-02-02 1984-01-31 사이클릭 펩타이드의 제조방법

Country Status (15)

Country Link
US (1) US4621073A (https=)
EP (1) EP0117447B1 (https=)
JP (1) JPS59141549A (https=)
KR (1) KR850000468A (https=)
AT (1) ATE31314T1 (https=)
AU (1) AU566208B2 (https=)
CA (1) CA1245638A (https=)
DE (2) DE3303345A1 (https=)
DK (1) DK45784A (https=)
ES (1) ES8500219A1 (https=)
GR (1) GR79752B (https=)
IE (1) IE56718B1 (https=)
IL (1) IL70848A (https=)
PT (1) PT78046B (https=)
ZA (1) ZA84739B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4505897A (en) * 1983-04-18 1985-03-19 The Administrators Of The Tulane Educational Fund Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith
US4612366A (en) * 1985-06-17 1986-09-16 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
US5965694A (en) * 1992-09-01 1999-10-12 The Trustees Of The University Of Pennsylvania Somatostatin mimics and synthetic methods therefor
US5700905A (en) * 1992-09-01 1997-12-23 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
US6001960A (en) * 1992-09-01 1999-12-14 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
GB0318682D0 (en) * 2003-08-08 2003-09-10 Novartis Ag Organic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs

Also Published As

Publication number Publication date
EP0117447A1 (de) 1984-09-05
CA1245638A (en) 1988-11-29
PT78046A (de) 1984-03-01
ES529301A0 (es) 1984-10-01
AU2399784A (en) 1984-08-09
ATE31314T1 (de) 1987-12-15
GR79752B (https=) 1984-10-31
IE56718B1 (en) 1991-11-20
JPS59141549A (ja) 1984-08-14
AU566208B2 (en) 1987-10-15
US4621073A (en) 1986-11-04
IE840243L (en) 1984-08-02
PT78046B (de) 1986-07-15
IL70848A0 (en) 1984-05-31
DK45784A (da) 1984-08-03
ZA84739B (en) 1984-09-26
IL70848A (en) 1987-10-30
DE3303345A1 (de) 1984-08-02
EP0117447B1 (de) 1987-12-09
DK45784D0 (da) 1984-02-01
ES8500219A1 (es) 1984-10-01
DE3468031D1 (en) 1988-01-21

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19840131

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19890130

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19840131

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19910723

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19910930

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19910723

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I