KR890701118A - 혈소판 감소증 예방 및 치료제 - Google Patents
혈소판 감소증 예방 및 치료제Info
- Publication number
- KR890701118A KR890701118A KR1019890700778A KR890700778A KR890701118A KR 890701118 A KR890701118 A KR 890701118A KR 1019890700778 A KR1019890700778 A KR 1019890700778A KR 890700778 A KR890700778 A KR 890700778A KR 890701118 A KR890701118 A KR 890701118A
- Authority
- KR
- South Korea
- Prior art keywords
- thrombocytopenia
- prevention
- treatment
- general formula
- dipeptiide
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title claims 2
- 206010043554 thrombocytopenia Diseases 0.000 title claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229960001153 serine Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 하기 일반식의 무라밀디펩티드 유도체를 활성성분으로서 함유하는 혈소판 감소증예방 및 치료제 :상기식에서, X는 L - 알라닌, L - 세린 및 L - 발린중에서 선택된 아미노산 잔기이고 ; Y는 일반식 (여기에서, R1은 카복실그룹이고, n은 1 내지 6의 정수이며, A는 측쇄를 함유할 수 있는 포화된 C7 - 29지방족 탄화수소 그룹이다)이며 ; 아실은 C1- C6아실룹이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21993787 | 1987-09-02 | ||
JP219937/87 | 1987-09-02 | ||
PCT/JP1988/000883 WO1989001778A1 (en) | 1987-09-02 | 1988-09-02 | Agents for prophylaxis and treatment of thrombopenia |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890701118A true KR890701118A (ko) | 1989-12-19 |
KR970003049B1 KR970003049B1 (ko) | 1997-03-14 |
Family
ID=16743362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890700778A KR970003049B1 (ko) | 1987-09-02 | 1988-09-02 | 혈소판감소증 예방 및 치료제 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5037804A (ko) |
EP (1) | EP0331756B1 (ko) |
JP (1) | JP2545279B2 (ko) |
KR (1) | KR970003049B1 (ko) |
AU (1) | AU609524B2 (ko) |
DE (1) | DE3881377T2 (ko) |
WO (1) | WO1989001778A1 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2123912C (en) * | 1991-11-19 | 2007-04-17 | Roger Aston | Muramyl compounds for treatment of septic shock |
JP2002529502A (ja) | 1998-11-17 | 2002-09-10 | スミスクライン・ビーチャム・コーポレイション | 血小板減少症の治療法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5543030A (en) * | 1978-09-21 | 1980-03-26 | Dai Ichi Seiyaku Co Ltd | Prophylactic and remedy for microbial infection disease |
US4357322A (en) * | 1980-07-29 | 1982-11-02 | Syntex (U.S.A.) Inc. | Method of preventing, reducing or inhibiting inflammation |
US4684625A (en) * | 1982-07-08 | 1987-08-04 | Syntex (U.S.A.) Inc. | Method for enhancing the anti-infective activity of muramyldipeptide derivatives |
NL8401226A (nl) * | 1984-04-16 | 1985-11-18 | Univ Utrecht | Farmaceutisch produkt met anti-tumorwerking; gebruik van een farmaceutisch produkt of van farmaceutische samenstellingen in een anti-tumortherapie. |
JPS6227079A (ja) * | 1985-07-27 | 1987-02-05 | Toyota Motor Corp | ヘムシ−ラ加熱予備硬化方法 |
DK585886A (da) * | 1985-12-24 | 1987-06-25 | Takeda Chemical Industries Ltd | Immunstimulerende middel og anvendelse deraf |
US4895835A (en) * | 1987-11-20 | 1990-01-23 | Nisshin Oil Mills, Ltd. | Muramyl peptide derivatives and use thereof |
-
1988
- 1988-09-02 JP JP63507075A patent/JP2545279B2/ja not_active Expired - Lifetime
- 1988-09-02 US US07/381,718 patent/US5037804A/en not_active Expired - Fee Related
- 1988-09-02 DE DE8888907810T patent/DE3881377T2/de not_active Expired - Fee Related
- 1988-09-02 AU AU23210/88A patent/AU609524B2/en not_active Ceased
- 1988-09-02 KR KR1019890700778A patent/KR970003049B1/ko not_active IP Right Cessation
- 1988-09-02 EP EP88907810A patent/EP0331756B1/en not_active Expired - Lifetime
- 1988-09-02 WO PCT/JP1988/000883 patent/WO1989001778A1/ja active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US5037804A (en) | 1991-08-06 |
EP0331756A1 (en) | 1989-09-13 |
EP0331756A4 (en) | 1990-12-12 |
KR970003049B1 (ko) | 1997-03-14 |
DE3881377T2 (de) | 1993-09-23 |
EP0331756B1 (en) | 1993-05-26 |
DE3881377D1 (de) | 1993-07-01 |
JP2545279B2 (ja) | 1996-10-16 |
AU609524B2 (en) | 1991-05-02 |
WO1989001778A1 (en) | 1989-03-09 |
AU2321088A (en) | 1989-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2214418C2 (ru) | Аналоги glp-1 | |
KR890003720A (ko) | 벤조티아졸 및 그를 유효성분으로 함유하는 항류머티스제 | |
DE68922405D1 (de) | Deletionsanaloga von magaininpeptiden. | |
ES2075040T3 (es) | 2',3'-dideoxi-2',2'-difluoronucleosidos. | |
RU2002123877A (ru) | Кахалалидные соединения | |
DE59002863D1 (de) | Lysolecithinderivate zur behandlung von autoimmunerkrankungen. | |
KR900003163A (ko) | 시클로헥산 유도체 | |
KR960006915A (ko) | 췌장염의 치료 조성물 | |
ES8200353A1 (es) | Procedimiento para la obtencion de amidas de acido tetrazo- liloxicarboxilico de efecto herbicida | |
KR910019632A (ko) | 비스(알킬-치환-4-히드록시페닐티오)알칸 유사체를 유효성분으로 함유하는 백내장 발병 억제용 제약 조성물 | |
KR970061246A (ko) | 테스토스테론을 증가시키기 위한 약학 조성물 | |
ES2103440T3 (es) | Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
ES2059688T3 (es) | Derivados de aminoacidos inhibidores de enzimas, procedimiento para su preparacion, agentes que los contienen y su utilizacion. | |
KR890000009A (ko) | 농업용 생리활성제 | |
KR890701118A (ko) | 혈소판 감소증 예방 및 치료제 | |
ATE40987T1 (de) | Acetylenische phenoxypropanolderivate und pharmazeutische zusammensetzungen fuer die behandlung von bluthochdruck. | |
KR930009498A (ko) | 개선된 어류 양산법 | |
KR880012219A (ko) | p-히드록시 시남아미드 유도체 및 이를 함유한 멜라닌 억제제 | |
KR920018076A (ko) | 신규 폴리펩티드 | |
KR890001540A (ko) | 심부전증 치료제 | |
KR880002441A (ko) | 살균제 조성물 | |
KR880009644A (ko) | 궤양성 대장질환 치료용 약한 조성물 | |
KR910000645A (ko) | 개선된 경련치료제 | |
KR890017363A (ko) | 스트로빌루린 유도체, 이들의 제법 및 용도 | |
DE69006360D1 (de) | L-alpha-glycerophosphoryl-d-myoinositol zur behandlung peripherer neuropathien und cerebropathien. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |