KR850000445A - 6-(아미노메틸)페니실란 1,1-디옥사이드 에스테르의 제조방법 - Google Patents

6-(아미노메틸)페니실란 1,1-디옥사이드 에스테르의 제조방법 Download PDF

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Publication number
KR850000445A
KR850000445A KR1019840003121A KR840003121A KR850000445A KR 850000445 A KR850000445 A KR 850000445A KR 1019840003121 A KR1019840003121 A KR 1019840003121A KR 840003121 A KR840003121 A KR 840003121A KR 850000445 A KR850000445 A KR 850000445A
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South Korea
Prior art keywords
compound
formula
preparing
aminomethyl
methyl
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KR1019840003121A
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KR870000323B1 (ko
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에른스트 바즈 웨인
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윌리암 데이비스 휸
화이자 인코포레이티드
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Publication of KR850000445A publication Critical patent/KR850000445A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음.

Description

6-(아미노메틸)페니실란 1,1-디옥사이드 에스테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 다음 일반식(III) 또는 (IV)의 화물화을 완화한 수성산 조건하, 0내지 50℃에서 가수 분해시킴을 특징으로 하여, 다음 일반식(I) 또는 (II)의 알파- 또는 베타- 락담 에스테르 또는 약학적으로 허용되는 이의 산부가염을 제조하는 방법.
    상기식에서 Y'는 (C1-C3)알킬이고 R1은 수소이거나, 생리학적 조건하에서 가수분해 가능한 통상의 에스테르-형성라디칼이다.
  2. 제1항에 있어서, R1이 -CHR2OCOR3또는 -CHR20COOR3이고 R2가 수소 또는 메틸이고, R3가 (C1-C6)알킬인 방법.
  3. 제2항에 있어서, R1이
    인 방법.
  4. 제1,2 또는 3항에 있어서, Y'가 메틸인 방법.
  5. 제1항에 있어서, 일반식(III)화합들을 일반식(I)화합물로 전환시키는 방법.
  6. 제1항에 있어서, 일반식(IV)화합물을 일반식(II)화합물로 전환시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840003121A 1983-06-06 1984-06-05 6-(아미노메틸)페니실란 1,1-디옥사이드 에스테르의 제조방법 KR870000323B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50145183A 1983-06-06 1983-06-06
US501,451 1983-06-06
US577,478 1984-02-06
US06/577,478 US4536393A (en) 1983-06-06 1984-02-06 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor

Publications (2)

Publication Number Publication Date
KR850000445A true KR850000445A (ko) 1985-02-27
KR870000323B1 KR870000323B1 (ko) 1987-02-27

Family

ID=27053819

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840003121A KR870000323B1 (ko) 1983-06-06 1984-06-05 6-(아미노메틸)페니실란 1,1-디옥사이드 에스테르의 제조방법

Country Status (19)

Country Link
US (1) US4536393A (ko)
EP (1) EP0128719B1 (ko)
KR (1) KR870000323B1 (ko)
AT (1) ATE23862T1 (ko)
AU (1) AU551338B2 (ko)
CA (1) CA1206957A (ko)
DE (1) DE3461467D1 (ko)
DK (1) DK275784A (ko)
ES (1) ES533146A0 (ko)
FI (1) FI842254A (ko)
GR (1) GR82215B (ko)
HU (1) HU193930B (ko)
IL (1) IL72005A (ko)
NO (1) NO842249L (ko)
NZ (1) NZ208382A (ko)
PH (1) PH19077A (ko)
PL (1) PL143943B1 (ko)
PT (1) PT78688A (ko)
YU (1) YU97384A (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4590073A (en) * 1984-10-22 1986-05-20 Pfizer Inc. 6-substituted penicillanic acid 1,1-dioxide compounds
US4613462A (en) * 1985-07-02 1986-09-23 Pfizer, Inc. 6-substituted penicillanic acid 1,1-dioxide compounds
US5006661A (en) * 1987-06-16 1991-04-09 University Of Cincinnati Selective stereospecific biologically active beta-lactams
US4855419A (en) * 1987-06-16 1989-08-08 University Of Cincinnati Application of 4-[1-oxoalkyl]-2,5-oxazolidinediones in selective stereospecific formation of biologically active α-lactams
GB2206579B (en) * 1987-07-10 1991-05-29 Erba Farmitalia 6a and 6b-(substituted methyl)-penicillanic acid derivatives

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487079A (en) * 1966-01-14 1969-12-30 Bristol Myers Co Certain alpha-amino bicyclic beta-lactam carboxylic acids
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49880B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
US4237051A (en) * 1979-04-19 1980-12-02 Schering Corporation Stereospecific production of 6- or 7-carbon-substituted-β-lactams
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
US4260598A (en) * 1979-10-22 1981-04-07 Pfizer Inc. Method for increasing antibacterial effectiveness of a β-lactam antibiotic
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
EP0069962B1 (en) * 1981-07-15 1985-01-02 Kanebo, Ltd. Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
JPS5832882A (ja) * 1981-07-18 1983-02-25 Kanebo Ltd ６−〔（ヘキサヒドロ−１ｈ−アゼピン−１−イル）メチレンアミノ〕ペニシラン酸の新規エステルおよびその製造法

Also Published As

Publication number Publication date
US4536393A (en) 1985-08-20
HUT34202A (en) 1985-02-28
ATE23862T1 (de) 1986-12-15
PL143943B1 (en) 1988-03-31
ES8506023A1 (es) 1985-06-01
NZ208382A (en) 1987-05-29
DK275784D0 (da) 1984-06-04
PT78688A (en) 1984-07-01
EP0128719A1 (en) 1984-12-19
DK275784A (da) 1984-12-07
AU2907884A (en) 1984-12-13
CA1206957A (en) 1986-07-02
FI842254A0 (fi) 1984-06-05
EP0128719B1 (en) 1986-11-26
IL72005A0 (en) 1984-10-31
YU97384A (en) 1986-06-30
DE3461467D1 (en) 1987-01-15
GR82215B (ko) 1984-12-13
IL72005A (en) 1988-02-29
NO842249L (no) 1984-12-07
PH19077A (en) 1985-12-19
AU551338B2 (en) 1986-04-24
KR870000323B1 (ko) 1987-02-27
PL248044A1 (en) 1985-03-26
FI842254A (fi) 1984-12-07
ES533146A0 (es) 1985-06-01
HU193930B (en) 1987-12-28

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