KR840008281A - 서방출 정제의 제조방법 - Google Patents
서방출 정제의 제조방법 Download PDFInfo
- Publication number
- KR840008281A KR840008281A KR1019840002044A KR840002044A KR840008281A KR 840008281 A KR840008281 A KR 840008281A KR 1019840002044 A KR1019840002044 A KR 1019840002044A KR 840002044 A KR840002044 A KR 840002044A KR 840008281 A KR840008281 A KR 840008281A
- Authority
- KR
- South Korea
- Prior art keywords
- polyacrylate
- active
- tablets
- active material
- sustained release
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- 239000007939 sustained release tablet Substances 0.000 title 1
- 229920000058 polyacrylate Polymers 0.000 claims 7
- 239000000463 material Substances 0.000 claims 6
- 239000011149 active material Substances 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000011261 inert gas Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 활성물질이 서방출되는 분할가능 정제제조에 있어서, 폴리아크릴레이드 물질과 함께 약학적으로 활성물질을 유기용매에 용해시키고, 용매를 증발시킨후, 고체활성물질 함유 폴리아크릴레이트를 그라스 온도 이하의 저온에서 분쇄하여, 활성물질 함유 폴리아크릴레이트 분말을 정제용 부형제와 함께과 립화하고, 과립을 정제로 압축시킴을 특징으로 하는 방법.
- 제1항에 있어서, 분쇄물질을 고체 또는 액체 이산화탄소, 액체공기, 액체질소 혹은 다른 액화불활성 가스를 사용하여 냉각시킴을 특징으로 하는 방법.
- 제1항 또는 2항에 있어서, 불활성 충진제를 분쇄물질에 첨가함을 특징으로 하는 방법.
- 제3항에 있어서, 충진제로서 락토오즈, 미분쇄된 실리카, 마그네슘 스테아레이트 또는 다른 미분쇄된활탁제를 사용함을 특징으로 하는 방법.
- 제1항에 있어서, 정제용 부형제와 폴리아크릴레이트 물질의 압측공간과 폴리머중의 분자상 분산물로서 혼입된 활성물질을 포함함을 특징으로 하는 활성물질이 서방출되는 분할가능한 폴리아크릴레이트-기제 정제를 제조하는 방법.
- 제5항에 있어서, 폴리아크릴레이트 물질이 평균 분자량 약 800,000을 갖는 아크릴산 및 메트아크릴산의 메틸 및/또는 에틸 에스테르의 공중합체를 포함함을 특징으로 하는 방법.
- 제6항에 있어서, 산성 또는 염기성 그룹을 갖는 에틸렌폴리머가 폴리아크릴레이트 물질과 혼합됨을 특징으로 하는 방법.
- 제5항 내지 제7항 중 어느 항에 있어서, 활성물질로서 1회 용량 50mg 까지이며 분자량 약 500까지 이고 확산계수 약 10-5내지 10-7cm2·h-1를 갖는 유기물질을 함유함을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833314003 DE3314003A1 (de) | 1983-04-18 | 1983-04-18 | Teilbare tablette mit verzoegerter wirkstofffreigabe und verfahren zu deren herstellung |
DEP3314003.0 | 1983-04-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840008281A true KR840008281A (ko) | 1984-12-14 |
KR910001924B1 KR910001924B1 (ko) | 1991-03-30 |
Family
ID=6196696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840002044A KR910001924B1 (ko) | 1983-04-18 | 1984-04-18 | 서방출 정제의 제조방법 |
Country Status (27)
Country | Link |
---|---|
US (3) | US4547359A (ko) |
EP (1) | EP0122574B2 (ko) |
JP (1) | JPH0623096B2 (ko) |
KR (1) | KR910001924B1 (ko) |
AT (1) | ATE23110T1 (ko) |
AU (1) | AU575045B2 (ko) |
CA (1) | CA1232202A (ko) |
CS (1) | CS247079B2 (ko) |
DD (1) | DD223063A5 (ko) |
DE (2) | DE3314003A1 (ko) |
DK (1) | DK161183C (ko) |
ES (1) | ES531684A0 (ko) |
FI (1) | FI80590C (ko) |
GB (1) | GB2138290B (ko) |
GR (1) | GR79858B (ko) |
HK (1) | HK1690A (ko) |
HU (1) | HU191558B (ko) |
IE (1) | IE57141B1 (ko) |
IL (1) | IL71558A (ko) |
NO (1) | NO164957C (ko) |
NZ (1) | NZ207876A (ko) |
PH (1) | PH19612A (ko) |
PL (1) | PL144291B1 (ko) |
PT (1) | PT78434B (ko) |
SG (1) | SG68889G (ko) |
SU (1) | SU1356951A3 (ko) |
ZA (1) | ZA842815B (ko) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3314003A1 (de) * | 1983-04-18 | 1984-10-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Teilbare tablette mit verzoegerter wirkstofffreigabe und verfahren zu deren herstellung |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US4666705A (en) * | 1985-06-03 | 1987-05-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
DE3525767A1 (de) * | 1985-07-19 | 1987-01-22 | Boehringer Ingelheim Kg | Pharmazeutische zubereitung mit kontrollierter und verzoegerter wirkstofffreigabe und verfahren zu deren herstellung |
US4970075A (en) * | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
WO1988007366A1 (en) * | 1987-03-25 | 1988-10-06 | E.I. Du Pont De Nemours And Company | Use of vinyl alcohol homopolymers and copolymers for tableting active materials |
GB8707416D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
US5051261A (en) * | 1987-11-24 | 1991-09-24 | Fmc Corporation | Method for preparing a solid sustained release form of a functionally active composition |
US5445830A (en) * | 1989-07-25 | 1995-08-29 | Otsuka Pharmaceutical Co., Ltd. | Highly absorbable pharmaceutical composition |
DE4029591C2 (de) * | 1990-09-19 | 1995-01-26 | Stockhausen Chem Fab Gmbh | Verfahren zur Herstellung von Absorptionsmaterial auf Polymerbasis mit Zusatz von wasserlöslichen Substanzen und Verwendung dieses Absorptionsmaterials zur Aufnahme und/oder zur nachfolgenden Abgabe von Wasser oder wäßrigen Lösungen |
DE4032096C2 (de) * | 1990-10-10 | 1995-03-30 | Boehringer Ingelheim Kg | Verwendung emulgatorfreier Emulsionspolymere in pharmazeutischen Zubereitungen mit verzögerter Wirkstofffreigabe |
US5266331A (en) * | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
DE4406424A1 (de) * | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
FR2766089B1 (fr) * | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
US6699963B2 (en) | 2002-03-18 | 2004-03-02 | The Procter & Gamble Company | Grinding process for plastic material and compositions therefrom |
US6770099B2 (en) | 2002-11-19 | 2004-08-03 | Zimmer Technology, Inc. | Femoral prosthesis |
ES2620293T3 (es) | 2005-09-09 | 2017-06-28 | Paladin Labs Inc. | Composición de liberación sostenida de fármacos |
US20070160960A1 (en) * | 2005-10-21 | 2007-07-12 | Laser Shot, Inc. | System and method for calculating a projectile impact coordinates |
AU2007266574A1 (en) * | 2006-06-01 | 2007-12-06 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
US7985419B1 (en) | 2006-12-22 | 2011-07-26 | Watson Laboratories, Inc. | Divisible tablet and associated methods |
US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB768291A (en) * | 1953-12-16 | 1957-02-13 | Schering Corp | Pharmaceutical tablets |
BE575343A (ko) * | 1955-09-09 | |||
US2987445A (en) * | 1958-10-10 | 1961-06-06 | Rohm & Haas | Drug composition |
US3087860A (en) * | 1958-12-19 | 1963-04-30 | Abbott Lab | Method of prolonging release of drug from a precompressed solid carrier |
BE632692A (ko) * | 1963-05-28 | |||
CH468192A (de) * | 1964-06-19 | 1969-02-15 | Ciba Geigy | Verfahren zur Herstellung von Arzneimitteln in Perlenform |
AT270071B (de) * | 1966-08-12 | 1969-04-10 | Roehm & Haas Gmbh | Dragierlack für Arzneiformen |
US3608063A (en) * | 1969-08-15 | 1971-09-21 | Gilbert S Banker | Molecular drug entrapment process and compositions |
US3629392A (en) * | 1969-08-15 | 1971-12-21 | Gilbert S Banker | Entrapment compositions and processes |
DE2031871C3 (de) * | 1970-06-27 | 1974-06-27 | Roehm Gmbh, 6100 Darmstadt | Überzugsmasse für Arzneiformen |
CH582002A5 (ko) * | 1972-06-09 | 1976-11-30 | Purdue Research Foundation | |
US4013820A (en) * | 1974-11-07 | 1977-03-22 | Abbott Laboratories | Universally useable tableting ingredients |
JPS51118817A (en) * | 1975-04-08 | 1976-10-19 | Nippon Shinyaku Co Ltd | A process for preparing absorbable steroid glycoside pharmaceutical |
US4248855A (en) * | 1976-08-27 | 1981-02-03 | Hydrophilics International, Inc. | Pharmaceutical base salts |
US4391797A (en) * | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
GB1576376A (en) * | 1977-03-30 | 1980-10-08 | Benzon As Alfred | Multiple-unit drug dose |
NZ189022A (en) * | 1977-12-08 | 1981-11-19 | Beecham Group Ltd | Pharmaceutically acceptable particles of clavulanates dispersed in a polymeric binder |
DD146547A5 (de) * | 1978-07-15 | 1981-02-18 | Boehringer Sohn Ingelheim | Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen |
US4152415A (en) * | 1978-08-18 | 1979-05-01 | Iowa State University Research Foundation, Inc. | Method of increasing the effectiveness of oral vaccination for swine dysentery |
US4152413A (en) * | 1978-08-18 | 1979-05-01 | Chromalloy American Corporation | Oral vaccine for swine dysentery and method of use |
US4152414A (en) * | 1978-08-18 | 1979-05-01 | Iowa State University Research Foundation, Inc. | Combination vaccine for swine dysentery and method of use |
FI63335B (fi) * | 1979-02-02 | 1983-02-28 | Orion Yhtymae Oy | Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne |
US4258027A (en) * | 1979-03-26 | 1981-03-24 | Mead Johnson & Company | Multi-fractionable tablet structure |
CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
US4353887A (en) * | 1979-08-16 | 1982-10-12 | Ciba-Geigy Corporation | Divisible tablet having controlled and delayed release of the active substance |
EP0052076B1 (de) * | 1980-11-12 | 1985-05-29 | Ciba-Geigy Ag | Schnellzerfallende Arzneimittel-Presslinge |
DE3124090A1 (de) * | 1981-06-19 | 1983-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue orale dipyridamolformen |
US4357312A (en) * | 1981-07-16 | 1982-11-02 | The Children's Hospital Medical Center | Method of making prolonged release body |
DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
GB2119648A (en) * | 1982-05-06 | 1983-11-23 | Joseph Hodgson Briggs | Anorexogenic pharmaceutical composition |
DE3314003A1 (de) * | 1983-04-18 | 1984-10-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Teilbare tablette mit verzoegerter wirkstofffreigabe und verfahren zu deren herstellung |
-
1983
- 1983-04-18 DE DE19833314003 patent/DE3314003A1/de not_active Withdrawn
-
1984
- 1984-02-28 DK DK119084A patent/DK161183C/da not_active IP Right Cessation
- 1984-03-21 US US06/591,988 patent/US4547359A/en not_active Expired - Lifetime
- 1984-04-09 DE DE8484103930T patent/DE3461054D1/de not_active Expired
- 1984-04-09 EP EP84103930A patent/EP0122574B2/de not_active Expired - Lifetime
- 1984-04-09 AT AT84103930T patent/ATE23110T1/de not_active IP Right Cessation
- 1984-04-16 GR GR74433A patent/GR79858B/el unknown
- 1984-04-16 IL IL71558A patent/IL71558A/xx not_active IP Right Cessation
- 1984-04-16 DD DD84262017A patent/DD223063A5/de not_active IP Right Cessation
- 1984-04-16 NO NO841518A patent/NO164957C/no not_active IP Right Cessation
- 1984-04-16 FI FI841508A patent/FI80590C/fi not_active IP Right Cessation
- 1984-04-16 SU SU843725952A patent/SU1356951A3/ru active
- 1984-04-17 HU HU841484A patent/HU191558B/hu unknown
- 1984-04-17 AU AU27011/84A patent/AU575045B2/en not_active Expired
- 1984-04-17 GB GB08410010A patent/GB2138290B/en not_active Expired
- 1984-04-17 CA CA000452163A patent/CA1232202A/en not_active Expired
- 1984-04-17 PT PT78434A patent/PT78434B/pt unknown
- 1984-04-17 JP JP59077464A patent/JPH0623096B2/ja not_active Expired - Fee Related
- 1984-04-17 ES ES531684A patent/ES531684A0/es active Granted
- 1984-04-17 NZ NZ207876A patent/NZ207876A/en unknown
- 1984-04-17 ZA ZA842815A patent/ZA842815B/xx unknown
- 1984-04-17 IE IE945/84A patent/IE57141B1/en not_active IP Right Cessation
- 1984-04-17 PL PL1984247289A patent/PL144291B1/pl unknown
- 1984-04-18 CS CS842913A patent/CS247079B2/cs unknown
- 1984-04-18 PH PH30585A patent/PH19612A/en unknown
- 1984-04-18 KR KR1019840002044A patent/KR910001924B1/ko not_active IP Right Cessation
-
1985
- 1985-07-03 US US06/751,790 patent/US4595587A/en not_active Expired - Lifetime
-
1986
- 1986-01-31 US US06/824,782 patent/US4683131A/en not_active Expired - Lifetime
-
1989
- 1989-10-11 SG SG688/89A patent/SG68889G/en unknown
-
1990
- 1990-01-11 HK HK16/90A patent/HK1690A/xx not_active IP Right Cessation
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