KR840006969A - 치환된 1,4-디하이드로피리딘의 제조방법 - Google Patents

치환된 1,4-디하이드로피리딘의 제조방법 Download PDF

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Publication number
KR840006969A
KR840006969A KR1019830006046A KR830006046A KR840006969A KR 840006969 A KR840006969 A KR 840006969A KR 1019830006046 A KR1019830006046 A KR 1019830006046A KR 830006046 A KR830006046 A KR 830006046A KR 840006969 A KR840006969 A KR 840006969A
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KR
South Korea
Prior art keywords
mole
formula
compound
starting material
oxadiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019830006046A
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English (en)
Korean (ko)
Inventor
스쾨나핀게르(외 3) 칼
Original Assignee
한스-게오르그 우르바흐, 한스 오이흐너
카세라 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한스-게오르그 우르바흐, 한스 오이흐너, 카세라 아크티엔게젤샤프트 filed Critical 한스-게오르그 우르바흐, 한스 오이흐너
Publication of KR840006969A publication Critical patent/KR840006969A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Storage Of Fruits Or Vegetables (AREA)
  • Protection Of Plants (AREA)
KR1019830006046A 1982-12-20 1983-12-20 치환된 1,4-디하이드로피리딘의 제조방법 Ceased KR840006969A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823247118 DE3247118A1 (de) 1982-12-20 1982-12-20 Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DEP3247118.1 1982-12-20

Publications (1)

Publication Number Publication Date
KR840006969A true KR840006969A (ko) 1984-12-04

Family

ID=6181182

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830006046A Ceased KR840006969A (ko) 1982-12-20 1983-12-20 치환된 1,4-디하이드로피리딘의 제조방법

Country Status (20)

Country Link
US (1) US4558058A (cg-RX-API-DMAC10.html)
EP (1) EP0116708B1 (cg-RX-API-DMAC10.html)
JP (1) JPS59118783A (cg-RX-API-DMAC10.html)
KR (1) KR840006969A (cg-RX-API-DMAC10.html)
AT (1) ATE19776T1 (cg-RX-API-DMAC10.html)
AU (1) AU562583B2 (cg-RX-API-DMAC10.html)
CA (1) CA1194480A (cg-RX-API-DMAC10.html)
CS (1) CS241144B2 (cg-RX-API-DMAC10.html)
DD (1) DD215548A5 (cg-RX-API-DMAC10.html)
DE (2) DE3247118A1 (cg-RX-API-DMAC10.html)
DK (1) DK562683A (cg-RX-API-DMAC10.html)
ES (1) ES528175A0 (cg-RX-API-DMAC10.html)
FI (1) FI834451A7 (cg-RX-API-DMAC10.html)
GR (1) GR79484B (cg-RX-API-DMAC10.html)
HU (1) HU194556B (cg-RX-API-DMAC10.html)
NO (1) NO834480L (cg-RX-API-DMAC10.html)
PH (1) PH20327A (cg-RX-API-DMAC10.html)
PL (1) PL140526B1 (cg-RX-API-DMAC10.html)
SU (1) SU1360585A3 (cg-RX-API-DMAC10.html)
ZA (1) ZA839382B (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
DE3431152A1 (de) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel
DE3431862A1 (de) * 1984-08-30 1986-03-13 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5326772A (en) * 1984-09-28 1994-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Diaryl compounds for their use
JPS6191185A (ja) * 1984-10-11 1986-05-09 Sumitomo Seiyaku Kk 新規なオキサジアゾリル−１，４−ジヒドロピリジン誘導体
DE3443179A1 (de) * 1984-11-27 1986-05-28 Cassella Ag, 6000 Frankfurt 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung
US4650805A (en) * 1985-12-02 1987-03-17 Warner-Lambert Company 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
AU1626488A (en) * 1987-03-27 1988-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine enantiomers
SE8703881D0 (sv) * 1987-10-08 1987-10-08 Haessle Ab New pharmaceutical preparation
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
DE3807895A1 (de) * 1988-03-10 1989-09-21 Knoll Ag Erzeugnisse, enthaltend einen calciumantagonisten und einen lipidsenker
US5276150A (en) * 1989-05-31 1994-01-04 Fujirebio Inc. 1,4-dihydropyridine derivatives
FR2758459B1 (fr) 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
US6531158B1 (en) 2000-08-09 2003-03-11 Impax Laboratories, Inc. Drug delivery system for enhanced bioavailability of hydrophobic active ingredients
US7312337B2 (en) * 2004-09-30 2007-12-25 Eastman Kodak Company Oxadiazoles and their manufacture
DE102006044696A1 (de) * 2006-09-22 2008-03-27 Bayer Healthcare Ag 3-Cyano-5-thiazaheteroaryl-dihydropyridine und ihre Verwendung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647809A (en) * 1968-04-26 1972-03-07 Chinoin Gyogyszer Es Vegyeszet Certain pyridyl-1 2 4-oxadiazole derivatives
DE1963186C3 (de) * 1969-12-17 1979-02-15 Bayer Ag, 5090 Leverkusen Schwefelhaltige 1,4-Dihydropyridin-33-dicarbonsäureester
DE2005116C3 (de) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester
CA962269A (en) * 1971-05-05 1975-02-04 Robert E. Grahame (Jr.) Thiazoles, and their use as insecticides
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
US4144343A (en) * 1978-01-04 1979-03-13 Merck & Co., Inc. Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3022030A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use

Also Published As

Publication number Publication date
PL140526B1 (en) 1987-05-30
HU194556B (en) 1988-02-29
ATE19776T1 (de) 1986-05-15
EP0116708A1 (de) 1984-08-29
CA1194480A (en) 1985-10-01
FI834451A7 (fi) 1984-06-21
NO834480L (no) 1984-06-21
GR79484B (cg-RX-API-DMAC10.html) 1984-10-30
DE3363545D1 (en) 1986-06-19
DE3247118A1 (de) 1984-06-20
ES8406193A1 (es) 1984-08-01
CS961383A2 (en) 1985-07-16
PH20327A (en) 1986-12-02
US4558058A (en) 1985-12-10
DK562683A (da) 1984-06-21
SU1360585A3 (ru) 1987-12-15
AU562583B2 (en) 1987-06-11
JPS59118783A (ja) 1984-07-09
AU2253383A (en) 1984-06-28
ES528175A0 (es) 1984-08-01
PL245200A1 (en) 1985-02-27
DD215548A5 (de) 1984-11-14
ZA839382B (en) 1984-08-29
DK562683D0 (da) 1983-12-06
CS241144B2 (en) 1986-03-13
FI834451A0 (fi) 1983-12-05
EP0116708B1 (de) 1986-05-14

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Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19831220

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Patent event code: PA02012R01D

Patent event date: 19880210

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Patent event code: PA02011R01I

Patent event date: 19831220

Comment text: Patent Application

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Patent event date: 19900428

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19900713

Comment text: Decision to Refuse Application

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Patent event date: 19900428

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I