KR840006803A - 폴로프레닐화합물, 그 제법 및 그것을 함유하는 의약 - Google Patents

폴로프레닐화합물, 그 제법 및 그것을 함유하는 의약 Download PDF

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KR840006803A
KR840006803A KR1019830005659A KR830005659A KR840006803A KR 840006803 A KR840006803 A KR 840006803A KR 1019830005659 A KR1019830005659 A KR 1019830005659A KR 830005659 A KR830005659 A KR 830005659A KR 840006803 A KR840006803 A KR 840006803A
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polyprenyl
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이사오 야마쓰
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나이또오 유우지
에 자이 가부시기가이샤
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Abstract

내용 없음

Description

폴리프레닐화합물, 그 제법 및 그것을 함유하는 의약
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(Ⅱ)의 폴리프레닐 카르복시산 또는 그의 유도체를 일반식(Ⅲ)의 아민과 반응시켜 이 카르복시산 또는 그 유도체를 아민화시키는 것을 특징으로 하는 일반식(Ⅰ)의 폴리프레닐 화합물의 제조방법
    상기 식에서, A, B, Y 및 Z는 각기 수소이거나, 또는 A, B 및/또는 Y, Z는 그들이 부착되어 있는 탄소원자간에 서로 2중결합을 형성하는 직접원자가 결합을 표시하고 ; n는 0 또는 1내지 4의 정수이고 ; R은
    이고 ; X는 할로겐원자이고 ; m,q,ω 및 y는 각각 1내지 5의 정수이고 ; p,t,μ,υ 및 x는 각각 0내지 5의 정수이고, r과 s는 2 또는 3이고 ; k와 I은 같거나 다르고, 각각 1내지 5의 정수이고 ; R1,R3,R4,R5,R6,R7,R11,R12,R16,R17, 및 R18은 각각 수소 또는 저급알킬이고 ; R8,R9,R10,R13,R14및 R15는 각각 저급알킬이고 ; R2는 수소, 저급알킬 또는 아릴이다.
  2. 일반식(Ⅱ)의 화합물 또는 그의 반응성 유도체를 일반식(Ⅲa)내지 (Ⅲi) 중의 어느 한 아민화합물과 반응시킴을 특징으로 하는 일반식(Ⅰ″)의 폴리프레닐 화합물의 제조방법.
    상기식에서 A,B,Y 및 Z의 정의는 제1항에서와 같고 ; n은 1내지 3의 정수이며 ; X는
    중의 어느 한 기이며 ; a,b,c,d,e,f는 1내지 5의 정수이고 R30,R31,R32,R33,R34는 각각 저급 알킬기이고 ; R35,R36,R37,R38은 각각 수소 또는 저급알킬기이다.
  3. 일반식(Ⅳ)의 폴리프레닐 화합물을 일반식(Ⅴ)의 카르복시산과 반응시킴을 특징으로 하는 일반식(Ⅰ″)의 폴리프레닐 화합물의 제조방법.
    상기식에서 A,B,Y, 및 Z의 정의는 제1항에서와 같고 ; n은 1내지 3의 정수이며 ; g는 1내지 5의 정수이고 ; R39와 R40은 각각 수소 또는 저급알킬기이다.
  4. 일반식(Ⅵ)의 폴리프레닐 화합물의 할로겐화합물을 일반식(Ⅶ)의 아민화합물과 반응시켜 탈할로겐화함을 특징으로 하는 일반식(Ⅰ″)의 폴리프레닐 화합물의 제조방법.
    상기식에서 A, B, Y 및 Z의 정의는 제1항에서와 같고 ; n은 1내지 3의 정수이며 ; h는 1내지 5의 정수이고 ; Hal은 할로겐원자이고 ; R41과 R42는 각각 수소 또는 저급알킬기이다.
  5. 일반식(Ⅶ)의 화합물을 염화티오닐, 취화티오닐 또는 불화티오닐과 반응시켜 일반식(Ⅸ)의 산 할로겐합물을 얻고 이를 일반식(Ⅹ)의 아민화합물과 반응시키는 것을 특징으로 하는 일반식(Ⅰ″)의 폴리프레닐 화합물의 제조방법.
    상기식에서 A, B, Y 및 Z의 정의는 제1항에서와 같고 ; n은 1내지 3의 정수이고 ; Hal은 할로겐원자이고 ; R21은 수소, 저급알킬 또는 할로겐원자이고 ; R22는
    중의 어느 한 기이며 ; m,k,l,g,i는 각각 1내지 5의 정수이고 ; p는 0내지 5의 정수이고 ; R23,R24,R25는 각각 수소 또는 저급알킬이고 ; R26,R27,R28,R29는 각각 저급알킬이다.
  6. 일반식(XI)의 폴리프레닐 화합물을 염화티오닐, 취화티오닐 또는 불화티오닐과 반응시켜 일반식(XII)의 산할로겐화물을 얻고 이어 이 산화합물을 일반식(Ⅹ)의 아민화합물과 반응시킴을 특징으로 하는 일반식(Ⅰ″)의 폴리프레닐 화합물의 제조방법.
    상기식에서 A, B, Y 및 Z는 제1항의 정의와 같고 ; n은 1내지 3의 정수이고 ; Hal은 할로겐원자이고 ; K와 L은 모두 수소이거나 그들이 부착되어 있는 탄소원자간의 직접원자가 결합을 표시하고 ; R22는 제5항에서의 정의와 같다.
  7. 각 일반식(XIV), (XV), (XVI)의 폴리프레닐 화합물을 염화티오닐, 취화티오닐 또는 불화티오닐과 반응시켜 각 폴리프레닐 화합물의 산할로겐화물을 얻고 이를 일반식(Ⅹ)의 아민화합물과 반응시킴을 특징으로 하는 각 일반식(Ⅰ″a), (Ⅰ″b), (Ⅰ″c)의 프레닐 화합물을 제조하는 방법.
    상기식에서 A, B, Y 및 Z는 제1항에서의 정의와 같고 ; n은 1내지 3의 정수이고 ; R22는 제5항에서의 정의와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005659A 1982-11-30 1983-11-30 폴리프레닐 화합물의 제조방법 KR860001879B1 (ko)

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JP208678 1982-11-30
JP57208678A JPS59101448A (ja) 1982-11-30 1982-11-30 ポリプレニルカルボン酸アミドおよびその製造方法ならびにそれを含有する医薬

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JPS5791932A (en) * 1980-11-28 1982-06-08 Kuraray Co Ltd Polyprenyl compound
JPS60123451A (ja) * 1983-12-07 1985-07-02 Eisai Co Ltd ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
CA1280414C (en) * 1985-03-15 1991-02-19 Saichi Matsumoto Isoprenoidamine derivatives and antiulcer agents
JPH0629218B2 (ja) * 1985-03-15 1994-04-20 エーザイ株式会社 ポリプレニル系化合物
US4917045A (en) * 1988-07-22 1990-04-17 Ethyl Corporation Silicon compounds in poultry hatching
JPH0418056A (ja) * 1990-05-09 1992-01-22 Sanwa Kagaku Kenkyusho Co Ltd ポリイソプレン化合物及びその塩、これ等の製法並びにこれ等を有効成分とする消化性潰瘍治療剤
WO1992003415A1 (en) * 1990-08-14 1992-03-05 Nova Pharmaceutical Corporation Protein kinase c modulators
US5189046A (en) * 1990-08-14 1993-02-23 Nova Pharmaceutical Corporation Protein kinase C modulators
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
JP2007504256A (ja) * 2003-09-01 2007-03-01 メイン・ファ−マ・インタ−ナショナル・プロプライエタリ−・リミテッド 生物活性剤の送達のための組成物及び方法
CN1956716B (zh) * 2004-02-25 2010-12-15 国立大学法人东京大学 具有抑制转录因子klf5的活化作用的药物
IL187247A0 (en) 2007-11-08 2008-12-29 Hadasit Med Res Service Novel synthetic analogs of sphingolipids
ES2675356T3 (es) 2011-02-23 2018-07-10 Université D'aix-Marseille Uso de derivados de polyamina isoprenilo en tratamiento antibiótico o antiséptico

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH122286A (de) * 1925-09-02 1927-09-01 Chem Ind Basel Verfahren zur Darstellung einer neuen Gallensäureverbindung.
US2649438A (en) * 1950-10-28 1953-08-18 Ind Rayon Corp Copolymers of acrylonitrile and basic acrylamides
US2595907A (en) * 1950-12-30 1952-05-06 American Cyanamid Co Polymerizable and polymerized acrylonitrile-dialkylaminopropylacrylamide compositions
US2760977A (en) * 1953-06-03 1956-08-28 Research Corp N-alkylol unsaturated amides
US3528987A (en) * 1964-07-31 1970-09-15 Geigy Chem Corp N-(substituted pyridyl)rinolamides and -linolenamides
CH514550A (de) * 1966-09-15 1971-10-31 Zoecon Corp Verfahren zur Herstellung neuer ungesättigter Carbonsäureamide
US4021224A (en) * 1971-12-09 1977-05-03 Stauffer Chemical Company Herbicide compositions
US4148926A (en) * 1977-10-04 1979-04-10 Stauffer Chemical Company Dialkyl amino ethyl amides as anti-ripening agents
US4456603A (en) * 1979-08-14 1984-06-26 Eisai Co., Ltd. Polyprenylcarboxylic acid amides useful for treating liver dysfunction
JPS56113718A (en) * 1980-01-12 1981-09-07 Agency Of Ind Science & Technol Bifunctional terpenoid, its preparation, and ulcer preventive agent comprising it
JPS5731615A (en) * 1980-07-31 1982-02-20 Eisai Co Ltd Remedy for skin disease with keratinization
JPS57192340A (en) * 1981-05-18 1982-11-26 Nisshin Flour Milling Co Ltd Isoprenylamine derivative

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ES8600212A1 (es) 1985-10-01
ES534567A0 (es) 1985-09-01
ES8505936A1 (es) 1985-06-16
ES534571A0 (es) 1985-07-01
US4762829A (en) 1988-08-09
ES8506262A1 (es) 1985-07-01
EP0110397B1 (en) 1989-06-14
DE3380062D1 (en) 1989-07-20
ES534570A0 (es) 1985-06-16
ES8506593A1 (es) 1985-08-01
ES8506261A1 (es) 1985-07-01
EP0110397A2 (en) 1984-06-13
ES8601104A1 (es) 1985-10-16
EP0110397A3 (en) 1985-01-23
ES527634A0 (es) 1985-10-01
JPS59101448A (ja) 1984-06-12
ES534566A0 (es) 1985-08-01
PH20921A (en) 1987-06-05
ES8507470A1 (es) 1985-09-01
KR860001879B1 (ko) 1986-10-24
ES534569A0 (es) 1985-07-01
JPH0330585B2 (ko) 1991-04-30
US4742058A (en) 1988-05-03
CA1204750A (en) 1986-05-20
ES534568A0 (es) 1985-10-16

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