KR840006338A - 4-옥소-1,4-디하이드로 니코틴산 유도체의 제조방법 - Google Patents

4-옥소-1,4-디하이드로 니코틴산 유도체의 제조방법 Download PDF

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KR840006338A
KR840006338A KR1019830005102A KR830005102A KR840006338A KR 840006338 A KR840006338 A KR 840006338A KR 1019830005102 A KR1019830005102 A KR 1019830005102A KR 830005102 A KR830005102 A KR 830005102A KR 840006338 A KR840006338 A KR 840006338A
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oxo
carboxyl
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unsubstituted
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KR1019830005102A
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KR880000727B1 (ko
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히로까주 나리따
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나까노 다다오
도야마 가가꾸 고고가부시끼 가이샤
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Abstract

내용 없음

Description

4-옥소-1,4-디하이드로 니코틴산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(Ⅲ)의 화합물을 폐반환응시켜 하기 일반식(Ⅳ)의 4-옥소-1,4,5,6-테트라하이드로 니코틴산 유도체를 생성시킨후 이를 탈수소화 반응시킨후 이를 탈수소화 반응시키고, 필요에 따라 카복실-보호그룹을 제거시킴을 특징으로하여, 하기 일반식(Ⅰ)의 4-옥소-1,4-디하이드로 니코틴산 유도체 및 이의염을 제조하는 방법.
    상기 일반식에서 R1은 수소 또는 카복실-보호그룹이고, R2는 치환된 아릴그룹, 또는 비치환되거나 치환된 헤테로 사이클릭그룹이고, R3은 할로알킬그룹, 아미노 알킬그룹, 또는 비치환 되거나 치환된 알케닐, 아르알케닐, 아르알킬, 아르알카디에닐, 아르알키닐, 헤테로 사이클릭알킬, 헤테로사이클릭알케닐, 아릴, 사이클로알킬, 사이클로알케닐, 아실, 아미노알킬, 헤테로사이클릭 또는 가교된 탄화수고이고, R8은 R1에서와 동일한 카복실-보호그룹이다.
  2. 하기 일반식(Ⅳ)의 4-옥소-1,5,5,6-테트라하이드로니코틴산 유도체를 탈수소화시키고, 필요에 따라 카복실-보호그룹을 제거시킴을 특징으로 하여, 하기 일반식(Ⅰ)의 4-옥소-1,4-디하이드로니코틴산 유도체 및 이의 염을 제조하는 방법.
    상기 일반식에서, R1은 수소 또는 카복실-보호그룹이고, R2는 치환된 아릴그룹, 또는 비치환되거나 치환된 헤테로 사이클릭그룹이고, R3은 할로알킬그룹, 아미노알킬그룹, 또는 비치환 되거나 치환된 알케닐, 아르알케닐, 아르알킬, 아르알카디에닐, 아르알키닐, 헤테로사이클릭알킬, 헤테로사이클릭알케닐, 아릴, 사이클로알킬, 사이클로알케닐, 아실, 아미노알킬, 헤테로사이클릭 또는 가교된 탄화수고이고, R8은R1에서와 동일한 카복실-보호그룹이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005102A 1982-10-29 1983-10-28 4-옥소-1,4-디하이드로 니코틴산 유도체의 제조방법 KR880000727B1 (ko)

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JP188930/82 1982-10-29
JP188930 1982-10-29
JP57188930A JPS5980665A (ja) 1982-10-29 1982-10-29 ４−オキソ−１，４−ジヒドロニコチン酸誘導体
JP197624/83 1983-10-24
JP58197624A JPH066575B2 (ja) 1983-10-24 1983-10-24 ４―オキソ―１、４―ジヒドロニコチン酸またはその塩を含有する抗菌剤

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KR840006338A true KR840006338A (ko) 1984-11-29
KR880000727B1 KR880000727B1 (ko) 1988-04-29

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KR1019830005102A KR880000727B1 (ko) 1982-10-29 1983-10-28 4-옥소-1,4-디하이드로 니코틴산 유도체의 제조방법

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US (1) US4698352A (ko)
KR (1) KR880000727B1 (ko)
BE (1) BE898123A (ko)
CA (1) CA1326023C (ko)
CH (1) CH661505A5 (ko)
DE (1) DE3338846A1 (ko)
DK (1) DK160421C (ko)
FR (1) FR2535320B1 (ko)
GB (1) GB2130580B (ko)
IT (1) IT1218336B (ko)
SE (1) SE455092B (ko)

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CA1110234A (en) * 1978-01-18 1981-10-06 Hoffmann-La Roche Limited 4-pyridone-3-carboxylic acids and process for the preparation thereof
DE3346175A1 (de) * 1983-12-21 1985-07-11 Merck Patent Gmbh, 6100 Darmstadt Pyridylthiophene
NZ222968A (en) * 1986-12-24 1990-05-28 Allergan Inc Ethynylheteroaromatic derivatives and medicaments
US5149705A (en) * 1987-03-13 1992-09-22 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a tetralin group and having retinoid like activity
GB2238788A (en) * 1989-12-07 1991-06-12 Wellcome Found Tetrahydropyridine compounds
US5364869A (en) * 1992-03-09 1994-11-15 Abbott Laboratories Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists
GB9718375D0 (en) * 1997-08-29 1997-11-05 Zeneca Ltd Herbicidal method
AU1881900A (en) 1998-12-23 2000-07-31 Aventis Pharma Limited Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines
US8835437B2 (en) 2007-06-08 2014-09-16 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687918C (en) * 2007-06-08 2016-11-08 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
CL2008001671A1 (es) * 2007-06-08 2009-07-17 Janssen Pharmaceutica Nv Compuestos derivados de piperidina/piperazina inhibidores de dgat1, composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades metabolicas especialmente diabetes.
EP2296659B1 (en) 2008-06-05 2016-12-21 Janssen Pharmaceutica, N.V. Drug combinations comprising a DGAT inhibitor and a PPAR-agonist
AU2012302022A1 (en) 2011-08-29 2014-03-13 Ptc Therapeutics, Inc. Antibacterial compounds and methods for use
WO2013033258A1 (en) 2011-08-29 2013-03-07 Ptc Therapeutics, Inc. Antibacterial compounds and methods for use
EP3360554B1 (en) * 2015-10-05 2021-07-28 FUJIFILM Toyama Chemical Co., Ltd. Anti-hepatitis b virus agent
EP3604301B1 (en) 2017-03-31 2021-09-22 FUJIFILM Corporation 4-pyridone compound or salt thereof, and pharmaceutical composition and formulation including same
CN117136187A (zh) * 2021-06-24 2023-11-28 上海齐鲁制药研究中心有限公司 新型抗乙肝化合物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051142A (en) * 1976-05-24 1977-09-27 Rohm And Haas Company 1-Aryl-4-pyridones
US4115101A (en) * 1976-05-24 1978-09-19 Rohm And Haas Company 1-Aryl-4-pyridones
CA1110234A (en) * 1978-01-18 1981-10-06 Hoffmann-La Roche Limited 4-pyridone-3-carboxylic acids and process for the preparation thereof

Also Published As

Publication number Publication date
GB2130580A (en) 1984-06-06
CA1326023C (en) 1994-01-11
CH661505A5 (de) 1987-07-31
GB8328784D0 (en) 1983-11-30
GB2130580B (en) 1986-01-29
FR2535320B1 (fr) 1987-02-20
DK160421B (da) 1991-03-11
IT1218336B (it) 1990-04-12
KR880000727B1 (ko) 1988-04-29
US4698352A (en) 1987-10-06
DK493083A (da) 1984-04-30
SE455092B (sv) 1988-06-20
BE898123A (fr) 1984-04-30
IT8349240A0 (it) 1983-10-28
SE8305950L (sv) 1984-04-30
SE8305950D0 (sv) 1983-10-28
DE3338846C2 (ko) 1990-09-13
FR2535320A1 (fr) 1984-05-04
DK160421C (da) 1991-09-09
DK493083D0 (da) 1983-10-27
DE3338846A1 (de) 1984-05-03

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