KR840002453A - 뉴클레오시드 생산의 개량방법 - Google Patents

뉴클레오시드 생산의 개량방법 Download PDF

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KR840002453A
KR840002453A KR1019820005332A KR820005332A KR840002453A KR 840002453 A KR840002453 A KR 840002453A KR 1019820005332 A KR1019820005332 A KR 1019820005332A KR 820005332 A KR820005332 A KR 820005332A KR 840002453 A KR840002453 A KR 840002453A
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South Korea
Prior art keywords
oxygen
medium
inosine
adenine
guanosine
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KR1019820005332A
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English (en)
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KR880001455B1 (ko
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야스히로(외2) 스미노
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구라바야시 이꾸시로
다께다 야꾸힝 고오고 가부시끼가이샤
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Publication of KR880001455B1 publication Critical patent/KR880001455B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/818—Aeration or oxygen transfer technique
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음.

Description

뉴클레오시드 생산의 개량방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 아데닌-요구 및 이노신 및 또는 구아노산-생산 미생물이 발효 브로스중에서 이노신 및 또는 구아노신을 동화 및 축적할 수 있도록 하기 위하여 상기 미생물을 배양 배지중에서 배양하고 상기 브로스로부터 이노신 및 또는 구아노신을 회수함으로써 이노신 및 또는 구아노신을 생산함에 있어서, 보통의 공기를 사용하여 호기성 배양물에서 이노신 및 또는 구아노신을 수율의 최대로하는 아데닌의 양이상의 과량으로 아데닌원을 배지중에 존재하고 산소가 풍부한 기체를 배지중에 부글부글하게 공급하면서 상기 미생물을 배양함을 특징으로 하는 방법.
  2. 제1항에 있어서, 미생물이 바실루스 속에 속함을 특징으로 하는 방법.
  3. 제2항에 있어서, 미생물이 바실루스 푸밀루스 또는 바실루스 서브틸리스에 속함을 특징으로 하는 방법.
  4. 제3항에 있어서, 미생물이 부실루스 푸밀루스 No. 148-S-16(KAIST 820426-02210, FERM BP-6, IFO 12483), 바실루스 푸밀루스 No. 158-A-17(KAIST 820426-02110, FERM BP-7, IFO 12477) 및 바실루스 푸밀루스 ATCC 13956(IFO 14124)로 이루어진 군으로부터 선택된 것임을 특징으로 하는 방법.
  5. 제1항에 있어서, 배지중의 아데닌원의 양이 아데닌으로서 200∼800㎍/ml임을 특징으로 하는 방법.
  6. 제1항에 있어서, 공기 및 산소의 양이 하기식에 따라 배지중에 공급됨을 특징으로 하는 방법:
    상기식에서,및는, 각각, 배지중에 공급된 공기 및 산소의 양(l/분)이고, Q0(l/분)는 종래의 방법으로 공급된 보통 공기의 양이고 C는 산소 및 공기의 기체혼합물중의 산소농도(%)인데, 임의로 하기의 실험식으로부터 계산된 C0값 이하로 결정된다:
    [상기식에서, C0는 산소 및 공기의 기체 혼합물의 최소 산소 농도(%)를 나타내는데, 배지중 아데닌원의아데닌 당량의 농도가 Ad(중량/부피, %)인 경우 이노신 및 또는 구아노신의 최대 축적 수율을 얻기 위하여 필요하다].
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8205332A 1981-11-27 1982-11-26 뉴클레오시드 생산의 개량방법 KR880001455B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56191033A JPS5894397A (ja) 1981-11-27 1981-11-27 イノシンおよびグアノシンの製造法
JP191033/1981 1981-11-27

Publications (2)

Publication Number Publication Date
KR840002453A true KR840002453A (ko) 1984-07-02
KR880001455B1 KR880001455B1 (ko) 1988-08-10

Family

ID=16267773

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205332A KR880001455B1 (ko) 1981-11-27 1982-11-26 뉴클레오시드 생산의 개량방법

Country Status (7)

Country Link
US (1) US4578336A (ko)
EP (1) EP0080864B1 (ko)
JP (1) JPS5894397A (ko)
KR (1) KR880001455B1 (ko)
DE (1) DE3275388D1 (ko)
DK (1) DK162239C (ko)
ES (1) ES517702A0 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0757198B2 (ja) * 1987-10-07 1995-06-21 味の素株式会社 ジデオキシイノシンの製造方法
US5204245A (en) * 1991-05-15 1993-04-20 E. I. Du Pont De Nemours And Company Extraction of thymidine and other nucleosides
DE19938853B4 (de) * 1999-08-17 2005-09-29 Air Liquide Gmbh Verfahren zur Begasung einer Anlage für den anaeroben und/oder aeroben mikrobiellen Abbau und Umwandlung organischer Abfälle zu Gärrest und/oder Kompost sowie dazugehörige Anlage

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA662009A (en) * 1963-04-23 Tamagawa Yosio Process for producing nucleosides by microorganisms
US2038451A (en) * 1934-03-14 1936-04-21 Schattaneck Erich Device for aerating fermentation liquids
US3111459A (en) * 1959-10-19 1963-11-19 Ajinomoto Kk Method for preparation of inosine
IT1001452B (it) * 1965-06-11 1976-04-20 Ajinomoto Kk Metodo per produrre inosina mediante fermentazione
GB1175979A (en) * 1965-12-28 1970-01-01 Takeda Chemical Industries Ltd A method for the Production of 5'-Inosinic Acid and Inosine
GB1127544A (en) * 1969-08-19 1968-09-18 Ajinomoto Kk Method of preparing ribonucleosides by microorganism
JPS5417033B2 (ko) * 1973-06-14 1979-06-27
US3846246A (en) * 1974-01-09 1974-11-05 Dainippon Ink & Chemicals Cultivation process for micro-organisms
JPS5545199B2 (ko) * 1974-03-30 1980-11-17

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Publication number Publication date
ES8401527A1 (es) 1983-12-16
DE3275388D1 (en) 1987-03-12
DK162239B (da) 1991-09-30
KR880001455B1 (ko) 1988-08-10
ES517702A0 (es) 1983-12-16
EP0080864A2 (en) 1983-06-08
JPS6336757B2 (ko) 1988-07-21
US4578336A (en) 1986-03-25
EP0080864A3 (en) 1984-09-12
JPS5894397A (ja) 1983-06-04
EP0080864B1 (en) 1987-02-04
DK162239C (da) 1992-03-02
DK526882A (da) 1983-05-28

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