KR840002453A - 뉴클레오시드 생산의 개량방법 - Google Patents
뉴클레오시드 생산의 개량방법 Download PDFInfo
- Publication number
- KR840002453A KR840002453A KR1019820005332A KR820005332A KR840002453A KR 840002453 A KR840002453 A KR 840002453A KR 1019820005332 A KR1019820005332 A KR 1019820005332A KR 820005332 A KR820005332 A KR 820005332A KR 840002453 A KR840002453 A KR 840002453A
- Authority
- KR
- South Korea
- Prior art keywords
- oxygen
- medium
- inosine
- adenine
- guanosine
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 7
- 239000001301 oxygen Substances 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229930010555 Inosine Natural products 0.000 claims 6
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 6
- 229960003786 inosine Drugs 0.000 claims 6
- 239000002609 medium Substances 0.000 claims 6
- 244000005700 microbiome Species 0.000 claims 6
- 229930024421 Adenine Natural products 0.000 claims 5
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 5
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 5
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 5
- 229960000643 adenine Drugs 0.000 claims 5
- 229940029575 guanosine Drugs 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 241000194103 Bacillus pumilus Species 0.000 claims 4
- 239000007789 gas Substances 0.000 claims 3
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/813—Continuous fermentation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/818—Aeration or oxygen transfer technique
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/839—Bacillus subtilis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 아데닌-요구 및 이노신 및 또는 구아노산-생산 미생물이 발효 브로스중에서 이노신 및 또는 구아노신을 동화 및 축적할 수 있도록 하기 위하여 상기 미생물을 배양 배지중에서 배양하고 상기 브로스로부터 이노신 및 또는 구아노신을 회수함으로써 이노신 및 또는 구아노신을 생산함에 있어서, 보통의 공기를 사용하여 호기성 배양물에서 이노신 및 또는 구아노신을 수율의 최대로하는 아데닌의 양이상의 과량으로 아데닌원을 배지중에 존재하고 산소가 풍부한 기체를 배지중에 부글부글하게 공급하면서 상기 미생물을 배양함을 특징으로 하는 방법.
- 제1항에 있어서, 미생물이 바실루스 속에 속함을 특징으로 하는 방법.
- 제2항에 있어서, 미생물이 바실루스 푸밀루스 또는 바실루스 서브틸리스에 속함을 특징으로 하는 방법.
- 제3항에 있어서, 미생물이 부실루스 푸밀루스 No. 148-S-16(KAIST 820426-02210, FERM BP-6, IFO 12483), 바실루스 푸밀루스 No. 158-A-17(KAIST 820426-02110, FERM BP-7, IFO 12477) 및 바실루스 푸밀루스 ATCC 13956(IFO 14124)로 이루어진 군으로부터 선택된 것임을 특징으로 하는 방법.
- 제1항에 있어서, 배지중의 아데닌원의 양이 아데닌으로서 200∼800㎍/ml임을 특징으로 하는 방법.
- 제1항에 있어서, 공기 및 산소의 양이 하기식에 따라 배지중에 공급됨을 특징으로 하는 방법:상기식에서,및는, 각각, 배지중에 공급된 공기 및 산소의 양(l/분)이고, Q0(l/분)는 종래의 방법으로 공급된 보통 공기의 양이고 C는 산소 및 공기의 기체혼합물중의 산소농도(%)인데, 임의로 하기의 실험식으로부터 계산된 C0값 이하로 결정된다:[상기식에서, C0는 산소 및 공기의 기체 혼합물의 최소 산소 농도(%)를 나타내는데, 배지중 아데닌원의아데닌 당량의 농도가 Ad(중량/부피, %)인 경우 이노신 및 또는 구아노신의 최대 축적 수율을 얻기 위하여 필요하다].※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP191033/1981 | 1981-11-27 | ||
JP56191033A JPS5894397A (ja) | 1981-11-27 | 1981-11-27 | イノシンおよびグアノシンの製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840002453A true KR840002453A (ko) | 1984-07-02 |
KR880001455B1 KR880001455B1 (ko) | 1988-08-10 |
Family
ID=16267773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8205332A KR880001455B1 (ko) | 1981-11-27 | 1982-11-26 | 뉴클레오시드 생산의 개량방법 |
Country Status (7)
Country | Link |
---|---|
US (1) | US4578336A (ko) |
EP (1) | EP0080864B1 (ko) |
JP (1) | JPS5894397A (ko) |
KR (1) | KR880001455B1 (ko) |
DE (1) | DE3275388D1 (ko) |
DK (1) | DK162239C (ko) |
ES (1) | ES517702A0 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0757198B2 (ja) * | 1987-10-07 | 1995-06-21 | 味の素株式会社 | ジデオキシイノシンの製造方法 |
US5204245A (en) * | 1991-05-15 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Extraction of thymidine and other nucleosides |
DE19938853B4 (de) * | 1999-08-17 | 2005-09-29 | Air Liquide Gmbh | Verfahren zur Begasung einer Anlage für den anaeroben und/oder aeroben mikrobiellen Abbau und Umwandlung organischer Abfälle zu Gärrest und/oder Kompost sowie dazugehörige Anlage |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA662009A (en) * | 1963-04-23 | Tamagawa Yosio | Process for producing nucleosides by microorganisms | |
US2038451A (en) * | 1934-03-14 | 1936-04-21 | Schattaneck Erich | Device for aerating fermentation liquids |
US3111459A (en) * | 1959-10-19 | 1963-11-19 | Ajinomoto Kk | Method for preparation of inosine |
IT1001452B (it) * | 1965-06-11 | 1976-04-20 | Ajinomoto Kk | Metodo per produrre inosina mediante fermentazione |
GB1175979A (en) * | 1965-12-28 | 1970-01-01 | Takeda Chemical Industries Ltd | A method for the Production of 5'-Inosinic Acid and Inosine |
GB1127544A (en) * | 1969-08-19 | 1968-09-18 | Ajinomoto Kk | Method of preparing ribonucleosides by microorganism |
JPS5417033B2 (ko) * | 1973-06-14 | 1979-06-27 | ||
US3846246A (en) * | 1974-01-09 | 1974-11-05 | Dainippon Ink & Chemicals | Cultivation process for micro-organisms |
JPS5545199B2 (ko) * | 1974-03-30 | 1980-11-17 |
-
1981
- 1981-11-27 JP JP56191033A patent/JPS5894397A/ja active Granted
-
1982
- 1982-11-24 US US06/444,457 patent/US4578336A/en not_active Expired - Lifetime
- 1982-11-25 DE DE8282306287T patent/DE3275388D1/de not_active Expired
- 1982-11-25 EP EP82306287A patent/EP0080864B1/en not_active Expired
- 1982-11-26 ES ES517702A patent/ES517702A0/es active Granted
- 1982-11-26 DK DK526882A patent/DK162239C/da not_active IP Right Cessation
- 1982-11-26 KR KR8205332A patent/KR880001455B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS5894397A (ja) | 1983-06-04 |
ES8401527A1 (es) | 1983-12-16 |
DK162239C (da) | 1992-03-02 |
US4578336A (en) | 1986-03-25 |
EP0080864B1 (en) | 1987-02-04 |
EP0080864A3 (en) | 1984-09-12 |
ES517702A0 (es) | 1983-12-16 |
DE3275388D1 (en) | 1987-03-12 |
DK526882A (da) | 1983-05-28 |
DK162239B (da) | 1991-09-30 |
KR880001455B1 (ko) | 1988-08-10 |
EP0080864A2 (en) | 1983-06-08 |
JPS6336757B2 (ko) | 1988-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR850007983A (ko) | 히알우론산 생산의 발효법 | |
KR930018036A (ko) | 발효에 의한 아미노산 제조방법 | |
MY111441A (en) | Method of producing l-glutamic acid by fermentation | |
KR840002453A (ko) | 뉴클레오시드 생산의 개량방법 | |
JPH0673452B2 (ja) | 新規バチルス・ズブチリス | |
KR920006507A (ko) | L-발린의 제조방법 | |
US5545538A (en) | Method of producing vitamin B12 using rhizobium cobalaminogenum ferm BP-4429 | |
CA1239605A (en) | Production of uridine | |
GB1466009A (en) | Method for manufacture of maltose from starch by enzymes co- produced by a single microorganism | |
GB1474129A (en) | Method for the production of d-ribose | |
KR890701760A (ko) | 리보플라빈을 생성하는 미생물 균주 이들의 선택 및 발효를 위한 방법 | |
KR910005630B1 (ko) | 발효법에 의한 오로트산의 제조방법 | |
JP2535968B2 (ja) | インド―ル酢酸の製造方法 | |
US4430429A (en) | Production of vitamin B12 -activity substances | |
KR910016916A (ko) | 미생물 및 이를 이용한 바이오틴 바이타머의 생산방법 | |
JP2563074B2 (ja) | 天然型β−フェネチルアルコールの製造法 | |
KR900003742B1 (ko) | 5'-이노신산(5'-Inosinic Acid)을 생산하는 미생물 | |
KR880002995A (ko) | 푸럭토 올리고(Fructo-oligo)당의 제조방법 | |
KR900003741B1 (ko) | 5'-이노신산(5'-Inosinic Acid)을 생산하는 미생물 | |
KR930021793A (ko) | 미생물에 의한 l-로이신의 제조방법 | |
KR930008131A (ko) | 5'-크산틸산(5'Xanthyl산)을 생산하는 미생물 | |
KR850002280A (ko) | L-글루탐산의 개량 제조방법 | |
GB1433470A (en) | Process for producing guanosine-5,-monophosphate | |
JPH06113869A (ja) | S(+)−シトラマル酸の製造方法 | |
JPS6150598B2 (ko) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
G160 | Decision to publish patent application | ||
O035 | Opposition [patent]: request for opposition | ||
E902 | Notification of reason for refusal | ||
O063 | Decision on refusal after opposition [patent]: decision to refuse application | ||
J2X1 | Appeal (before the patent court) |
Free format text: TRIAL NUMBER: 1990201001179; APPEAL AGAINST DECISION TO DECLINE REFUSAL |
|
O073 | Decision to grant registration after opposition [patent]: decision to grant registration | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20010801 Year of fee payment: 14 |
|
LAPS | Lapse due to unpaid annual fee |