KR840002356A - 3-클로로-5-트리플루오로메틸피리딘의 제조방법 - Google Patents

3-클로로-5-트리플루오로메틸피리딘의 제조방법 Download PDF

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KR840002356A
KR840002356A KR1019820004933A KR820004933A KR840002356A KR 840002356 A KR840002356 A KR 840002356A KR 1019820004933 A KR1019820004933 A KR 1019820004933A KR 820004933 A KR820004933 A KR 820004933A KR 840002356 A KR840002356 A KR 840002356A
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Prior art keywords
trifluoromethylpyridine
chloro
derivative
dichloro
chlorine
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KR1019820004933A
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KR860001905B1 (ko
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간이찌 후지까와
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이시하라 겐조
이시하라상고 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.

Description

3－클로로－5－트리플루오로메틸피리딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 3－위에 수소원자를 갖는 5－트리플루오로메틸피리딘을 염소와 반응시킴으로써 3－클로로－5－트리플루오로메틸피리딘 유도체를 제조하기 위한 방법에서, 철, 안티몬, 구리 및 아연으로 이루어진 군으로부터 선택된 금속 원소의 염화물과 활성탄으로 이루어진 군으로부터 선택된 촉매 존재하 기상에서 상기 5－트리플루오로메틸피리딘 유도체를 염소와 반응시킴을 특징으로 하는 개량방법.
  2. 제1항에 있어서, 하기식(Ⅱ)를 갖는 3－클로로－5－트리플루오로메틸피리딘 유도체를 제조하기 위하여 하기식(Ⅰ)로 표시되는 5－트리플루오로메틸피리딘 유도체를 사용함을 특징으로 하는 방법.
    상기 식에서, Y는 염소 원자 또는 플루오르 원자이고 n은 0,1 또는 2이며, n이 2인 경우, Y는 동일 또는 상이해도 무방하며, m은 0,1,2 또는 3이며, m이 2 또는 3인 경우 Y는 동일 또는 상이해도 무방하다.
  3. 제1항에 있어서, 3－클로로－5－트리플루오로메틸피리딘 유도체로서, 3－클로로－5－트리플루오로메틸피리딘, 2,3－디클로로－5－트리플루오로메틸피리딘, 2－플루오로－3－클로로－5－트리플루오로메틸피라딘, 3,6－디클로로－5－트리플루오로메틸피리딘 또는 2,3,6－트리클로로－5－트리플루오로메틸피리딘을 제조하기 위하여 5－트리플루오로메틸피리딘 유도체로서, 각각, 5－트리플루오로메틸피리딘, 2－클로로－5－트리플루오로메틸피리딘, 2－플루오로－5－트리플루오로메틸피리딘, 6－클로로－5－트리플루오로메틸피리딘 또는 2,6－디클로로－5－트리플루오로메틸피리딘이 사용됨을 특징으로 하는 방법.
  4. 제1항에 있어서, 3－클로로－5－트리플루오로메릴 피리딘 유도체로서, 각각, 2,3－디클로로－5－트리플루오로메틸피리딘 또는 2,3,6－트리클로로－5－트리플루오로메틸피리딘을 제조하기 위하여 5－트리플로오로메틸피리딘 유도체로서 2－클로로－5－트리플루오로메틸피리딘 또는 2,6－디클로로－5－트리플루오로메틸피리딘이 사용됨을 특징으로 하는 방법.
  5. 제1항에 있어서, 사용된 촉매가 철, 안티몬, 구리 및 아연 중에서 선택된 금속 원소의 염화물이 활성탄 상에 담지됨을 특징으로 하는 방법.
  6. 제1항에 있어서, 촉매가 활성탄 상에 담지된 염화철로 이루어짐을 특징으로 하는 방법.
  7. 제1항에 있어서, 염소화 반응이 150∼400℃의 온도에서 수행됨을 특징으로 하는 방법.
  8. 제1항에 있어서, 2,3－디클로로－5－트리플루오로 메틸피리딘을 얻기 위하여 2－클로로－5－트리플로오로메틸피리딘을 150∼350℃에서 염소화시킴을 특징으로 하는 방법.
  9. 제8항에 있어서, 염소화반응이 180∼320℃의 온도에서 수행됨을 특징으로 하는 방법.
  10. 제1항에 있어서, 2,3,6－트리클로로－5－트리플루오로메틸피리딘을 얻기 위하여 2－클로로－5－트리플루오로메틸피리딘을 180∼400℃의 온도에서 염소화 시킴을 특징으로 하는 방법.
  11. 제10항에 있어서, 염소화반응이 200∼350℃의 온도에서 수행됨을 특징으로 하는 방법.
  12. 제1항에 있어서, 염소가 5－트리플루오로메틸피리딘 유도체 1몰당 0.5∼10몰의 양으로 사용됨을 특징으로 하는 방법.
  13. 제1항에 있어서, 염소가 5－트리플루오로메틸피리딘 유도체 1몰당 1∼5몽의 양으로 사용됨을 특징으로 하는 방법.
  14. 제1항에 있어서, 불활성 희석제가 염소화 반응을 위하여 사용됨을 특징으로 하는 방법.
  15. 제14항에 있어서, 불활성 희석제가 질소임을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR828204933A 1981-11-04 1982-11-04 3-클로로-5-트리플루오로메틸피리딘의 제조방법 KR860001905B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56176759A JPS5877863A (ja) 1981-11-04 1981-11-04 ３―クロロ―５―トリフルオロメチルピリジン系化合物の製造方法
JP176759 1981-11-04
JP81-176959 1981-11-04

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KR840002356A true KR840002356A (ko) 1984-06-25
KR860001905B1 KR860001905B1 (ko) 1986-10-24

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US (1) US4490534A (ko)
EP (1) EP0078410B1 (ko)
JP (1) JPS5877863A (ko)
KR (1) KR860001905B1 (ko)
BR (1) BR8206380A (ko)
CA (1) CA1191143A (ko)
CH (1) CH650499A5 (ko)
DE (1) DE3276431D1 (ko)
GB (1) GB2108959B (ko)
ZA (1) ZA827633B (ko)

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EP0074192B1 (en) * 1981-09-03 1986-12-30 Imperial Chemical Industries Plc Chloro-trifluoromethyl pyridines
US4563530A (en) * 1984-10-29 1986-01-07 The Dow Chemical Company Preparation of fluoropyridines
IL78341A (en) * 1986-03-31 1989-08-15 Makhteshim Chem Works Ltd Method of preparing 2,3,6-trichloropyridine and 2,3,5,6-tetrachloropyridine in the gas phase
US5319088A (en) * 1991-11-26 1994-06-07 Dowelanco Selective gas phase chlorination of polychlorinated β-picolines to produce 2,3,5,6-tetrachloropyridine and its precursors
US5302765A (en) * 1992-05-29 1994-04-12 E. I. Du Pont De Nemours And Company Catalytic process for producing CF3 CHClF
US5602288A (en) * 1992-05-29 1997-02-11 E. I. Du Pont De Nemours And Company Catalytic process for producing CF3 CH2 F
JP3338876B2 (ja) * 1996-03-28 2002-10-28 住友精化株式会社 α−ハロアセトフェノン誘導体の製造方法
JP4056366B2 (ja) * 2002-11-20 2008-03-05 信越化学工業株式会社 塩化亜鉛担持体の製造方法
CN110475764B (zh) 2017-04-04 2023-03-31 石原产业株式会社 三氟甲基吡啶类的纯化方法
CN110003097B (zh) * 2018-01-05 2020-11-17 浙江省化工研究院有限公司 一种两段法制备2-氯-5-三氟甲基吡啶的方法
CN109879802B (zh) * 2017-12-06 2021-06-01 浙江省化工研究院有限公司 一种高选择性地制备2,3-二氯-5-三氟甲基吡啶的方法
US11186546B2 (en) 2017-12-06 2021-11-30 Zhejiang Lantian Environmental Protection Hi-Tech Co., Ltd. Method for preparing 2,3-dichloro-5-trifluoromethylpyridine with high selectivity
EP4105202B1 (en) * 2018-01-05 2024-05-01 Zhejiang Lantian Environmental Protection Hi-Tech Co., Ltd. Method for preparing 2-chloro-5-trifluoromethylpyridine
JP2021118993A (ja) * 2018-04-23 2021-08-12 石原産業株式会社 インターナル、流動層反応装置、およびトリフルオロメチルピリジン系化合物の製造方法
CN110627711B (zh) * 2018-06-22 2021-02-05 浙江省化工研究院有限公司 一种氯代三氟甲基吡啶的制备方法
CN109988102B (zh) * 2019-05-14 2020-09-18 中触媒新材料股份有限公司 一种2,3-二氯-5-三氟甲基吡啶的制备方法

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* Cited by examiner, † Cited by third party
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NL130304C (ko) * 1964-02-12
JPS5543017A (en) * 1978-09-22 1980-03-26 Ishihara Sangyo Kaisha Ltd Preparation of 2-chloro-5-trichloromethylpyridine
DE2965804D1 (en) * 1978-12-07 1983-08-04 Ici Plc Preparation of 2-chloro-5-trifluoromethylpyridine
NZ192948A (en) * 1979-03-09 1982-02-23 Ishihara Sangyo Kaisha Preparation of beta-trifuloromethyl-pyridine derivatives directly from beta-picoline
JPS5690059A (en) * 1979-12-24 1981-07-21 Ishihara Sangyo Kaisha Ltd Preparation of 2,3-dihalogeno-5-trifluoromethylpyridine
JPS5697271A (en) * 1979-12-28 1981-08-05 Ishihara Sangyo Kaisha Ltd Preparation of dihalogeno-5-trifluoromethylpyridine
JPS5946307B2 (ja) * 1980-02-28 1984-11-12 株式会社クボタ ホ−ロ−引き浴槽の施釉方法
JPS56125369A (en) * 1980-03-07 1981-10-01 Ishihara Sangyo Kaisha Ltd Preparation of 3-halogeno-5-trifluoromethylpyridine compound
US4331811A (en) * 1981-03-12 1982-05-25 The Dow Chemical Company Preparation of 2,3-dichloro-5-trichloromethylpyridine
EP0074192B1 (en) * 1981-09-03 1986-12-30 Imperial Chemical Industries Plc Chloro-trifluoromethyl pyridines
JPS5855460A (ja) * 1982-09-03 1983-04-01 インペリアル・ケミカル・インダストリ−ズ・ピ−エルシ− クロロトリフルオロメチルピリジン類の製造法

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Publication number Publication date
DE3276431D1 (en) 1987-07-02
US4490534A (en) 1984-12-25
GB2108959A (en) 1983-05-25
EP0078410A2 (en) 1983-05-11
JPS5877863A (ja) 1983-05-11
KR860001905B1 (ko) 1986-10-24
EP0078410A3 (en) 1984-04-25
JPS6346748B2 (ko) 1988-09-19
CA1191143A (en) 1985-07-30
GB2108959B (en) 1985-07-10
BR8206380A (pt) 1983-09-27
ZA827633B (en) 1983-08-31
CH650499A5 (de) 1985-07-31
EP0078410B1 (en) 1987-05-27

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