JPS5690059A - Preparation of 2,3-dihalogeno-5-trifluoromethylpyridine - Google Patents
Preparation of 2,3-dihalogeno-5-trifluoromethylpyridineInfo
- Publication number
- JPS5690059A JPS5690059A JP16789579A JP16789579A JPS5690059A JP S5690059 A JPS5690059 A JP S5690059A JP 16789579 A JP16789579 A JP 16789579A JP 16789579 A JP16789579 A JP 16789579A JP S5690059 A JPS5690059 A JP S5690059A
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethylpyridine
- halogeno
- pyridone
- trifluoromethyl
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyridine Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound in high yield in a few stages without problems of waste water treatment, by reacting a 2-halogeno-5-trifluoromethylpyridine with an alkaline substance, and halogenating the reaction product in two stages.
CONSTITUTION: A 2-halogeno-5-trifluoromethylpyridine is added to a solution in which an alkaline substance is dissolved in a solvent, and heated at 50W130°C to give 5-trifluoromethyl-2-pyridone. The resultant pyridone is then reacted with a relatively weak halogenating agent, e.g. chlorine gas or bromine, in the presence of a solvent at 0W100°C, preferably 20W60°C, to form a 3-halogeno-5-trifluoromethyl-2- pyridone, which is further reacted with a halogenating agent, e.g. thonyl chloride or phosphous oxybromide, at 20W150°C, preferably 50W100°C, to give the aimed compound. The reaction in the second stage can be carried out continuously without isolating the halogenation product obtained in the first stage.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16789579A JPS5690059A (en) | 1979-12-24 | 1979-12-24 | Preparation of 2,3-dihalogeno-5-trifluoromethylpyridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16789579A JPS5690059A (en) | 1979-12-24 | 1979-12-24 | Preparation of 2,3-dihalogeno-5-trifluoromethylpyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5690059A true JPS5690059A (en) | 1981-07-21 |
Family
ID=15858048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16789579A Pending JPS5690059A (en) | 1979-12-24 | 1979-12-24 | Preparation of 2,3-dihalogeno-5-trifluoromethylpyridine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5690059A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490534A (en) * | 1981-11-04 | 1984-12-25 | Ishihara Sangyo Kaisha Ltd. | Process for producing 3-chloro-5-trifluoromethylpyridines |
| EP0272824A2 (en) * | 1986-12-24 | 1988-06-29 | Imperial Chemical Industries Plc | Chemical compounds |
| CN107652228A (en) * | 2016-10-28 | 2018-02-02 | 广州南新制药有限公司 | Anti- kidney fibrosis medicine 1（Substituted benzyl）The synthetic method of 5 trifluoromethyl 2 (1H) pyridonium salt hydrochlorates |
-
1979
- 1979-12-24 JP JP16789579A patent/JPS5690059A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490534A (en) * | 1981-11-04 | 1984-12-25 | Ishihara Sangyo Kaisha Ltd. | Process for producing 3-chloro-5-trifluoromethylpyridines |
| EP0272824A2 (en) * | 1986-12-24 | 1988-06-29 | Imperial Chemical Industries Plc | Chemical compounds |
| CN107652228A (en) * | 2016-10-28 | 2018-02-02 | 广州南新制药有限公司 | Anti- kidney fibrosis medicine 1（Substituted benzyl）The synthetic method of 5 trifluoromethyl 2 (1H) pyridonium salt hydrochlorates |
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