JPS57134487A - Preparation of 7alpha-methoxycephalosporin compound - Google Patents

Preparation of 7alpha-methoxycephalosporin compound

Info

Publication number
JPS57134487A
JPS57134487A JP56019615A JP1961581A JPS57134487A JP S57134487 A JPS57134487 A JP S57134487A JP 56019615 A JP56019615 A JP 56019615A JP 1961581 A JP1961581 A JP 1961581A JP S57134487 A JPS57134487 A JP S57134487A
Authority
JP
Japan
Prior art keywords
compound shown
formula
methoxylation
compound
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56019615A
Other languages
Japanese (ja)
Other versions
JPH0132830B2 (en
Inventor
Seiichi Masai
Shinji Ueda
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP56019615A priority Critical patent/JPS57134487A/en
Publication of JPS57134487A publication Critical patent/JPS57134487A/en
Publication of JPH0132830B2 publication Critical patent/JPH0132830B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an antibacterial agent simply in high yield, by using 7β-side chain-Δ3-cephem-4-carboxylic acid having an amino-protecting group at 7-position to undergo easily 7α-methoxylation as a starting raw material.
CONSTITUTION: A compound shown by the formulaI(R1 is hydrocarbon group; A is H, halogen, alkyl, etc.; W is H, alkyl, aryl, etc.) is treated with a halogenating agent (e.g., chlorine, bromine) in the presence of an alkali metal salt (e.g., lithium methoxide) of methanol and methanol to give a compound shown by the formula II (W' is W), which is reacted with a compound shown by the formula III (R2 is H or carboxyl; R3 is H, carbamoyl, etc.) or its salt, to give a 7α-methoxycephalosporin compound shown by the formula IV. The compound shown by the formulaIis easily subjected to 7α-methoxylation, and after methoxylation, it can be introduced into the compound shown by the formula IV directly without removing the amino-protecting group.
COPYRIGHT: (C)1982,JPO&Japio
JP56019615A 1981-02-12 1981-02-12 Preparation of 7alpha-methoxycephalosporin compound Granted JPS57134487A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56019615A JPS57134487A (en) 1981-02-12 1981-02-12 Preparation of 7alpha-methoxycephalosporin compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56019615A JPS57134487A (en) 1981-02-12 1981-02-12 Preparation of 7alpha-methoxycephalosporin compound

Publications (2)

Publication Number Publication Date
JPS57134487A true JPS57134487A (en) 1982-08-19
JPH0132830B2 JPH0132830B2 (en) 1989-07-10

Family

ID=12004084

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56019615A Granted JPS57134487A (en) 1981-02-12 1981-02-12 Preparation of 7alpha-methoxycephalosporin compound

Country Status (1)

Country Link
JP (1) JPS57134487A (en)

Also Published As

Publication number Publication date
JPH0132830B2 (en) 1989-07-10

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