KR840000946B1 - 인슐린 전구체의 제조방법 - Google Patents

인슐린 전구체의 제조방법 Download PDF

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Publication number
KR840000946B1
KR840000946B1 KR1019810000989A KR810000989A KR840000946B1 KR 840000946 B1 KR840000946 B1 KR 840000946B1 KR 1019810000989 A KR1019810000989 A KR 1019810000989A KR 810000989 A KR810000989 A KR 810000989A KR 840000946 B1 KR840000946 B1 KR 840000946B1
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KR
South Korea
Prior art keywords
gly
insulin
leu
arg
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810000989A
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English (en)
Korean (ko)
Other versions
KR830005251A (ko
Inventor
힐 프랭크 브루스
Original Assignee
일라이 릴리 앤드 캄파니
아더 알 웨일
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26832281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR840000946(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 일라이 릴리 앤드 캄파니, 아더 알 웨일 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR830005251A publication Critical patent/KR830005251A/ko
Application granted granted Critical
Publication of KR840000946B1 publication Critical patent/KR840000946B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019810000989A 1980-03-27 1981-03-26 인슐린 전구체의 제조방법 Expired KR840000946B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13438980A 1980-03-27 1980-03-27
US134389 1980-03-27
US134,389 1980-03-27
US210,694 1980-11-26
US21069680A 1980-11-28 1980-11-28

Publications (2)

Publication Number Publication Date
KR830005251A KR830005251A (ko) 1983-08-03
KR840000946B1 true KR840000946B1 (ko) 1984-07-01

Family

ID=26832281

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000989A Expired KR840000946B1 (ko) 1980-03-27 1981-03-26 인슐린 전구체의 제조방법

Country Status (23)

Country Link
EP (1) EP0037255B2 (https=)
KR (1) KR840000946B1 (https=)
AR (1) AR224933A1 (https=)
AU (1) AU540644B2 (https=)
CA (1) CA1154435A (https=)
DD (1) DD157612A5 (https=)
DE (1) DE3161475D1 (https=)
DK (1) DK149863C (https=)
EG (1) EG15310A (https=)
ES (1) ES500747A0 (https=)
FI (1) FI810917A7 (https=)
GB (1) GB2073204B (https=)
GR (1) GR73517B (https=)
HU (1) HU185249B (https=)
IE (1) IE51172B1 (https=)
IL (1) IL62486A (https=)
NO (1) NO151898C (https=)
NZ (1) NZ196609A (https=)
PL (1) PL127843B1 (https=)
PT (1) PT72732B (https=)
RO (1) RO81951B (https=)
SU (1) SU1301319A3 (https=)
YU (1) YU76881A (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983003413A1 (en) * 1982-03-31 1983-10-13 Genetics Inst Creation of dna sequences encoding modified proinsulin precursors
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
ATE148710T1 (de) 1992-12-02 1997-02-15 Hoechst Ag Verfahren zur gewinnung von proinsulin mit korrekt verbundenen cystinbrücken
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten

Also Published As

Publication number Publication date
PT72732A (en) 1981-04-01
GB2073204A (en) 1981-10-14
EP0037255B1 (en) 1983-11-23
IL62486A0 (en) 1981-05-20
IE51172B1 (en) 1986-10-29
NZ196609A (en) 1984-02-03
NO151898C (no) 1985-06-26
SU1301319A3 (ru) 1987-03-30
AU540644B2 (en) 1984-11-29
NO811039L (no) 1981-09-28
PL230292A1 (https=) 1981-11-27
DE3161475D1 (en) 1983-12-29
GB2073204B (en) 1983-09-21
IE810679L (en) 1981-09-27
HU185249B (en) 1984-12-28
DK149863C (da) 1987-06-01
IL62486A (en) 1984-12-31
KR830005251A (ko) 1983-08-03
CA1154435A (en) 1983-09-27
AR224933A1 (es) 1982-01-29
RO81951B (ro) 1984-02-28
NO151898B (no) 1985-03-18
ES8201957A1 (es) 1982-01-16
DK136481A (da) 1981-09-28
AU6871981A (en) 1981-10-01
EP0037255B2 (en) 1989-04-05
DK149863B (da) 1986-10-13
FI810917L (fi) 1981-09-28
PT72732B (en) 1982-03-23
PL127843B1 (en) 1983-11-30
DD157612A5 (de) 1982-11-24
EG15310A (en) 1985-12-31
RO81951A (ro) 1984-02-21
GR73517B (https=) 1984-03-08
EP0037255A1 (en) 1981-10-07
YU76881A (en) 1984-04-30
FI810917A7 (fi) 1981-09-28
ES500747A0 (es) 1982-01-16

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