DE3161475D1 - Process for producing an insulin precursor - Google Patents

Process for producing an insulin precursor

Info

Publication number
DE3161475D1
DE3161475D1 DE8181301305T DE3161475T DE3161475D1 DE 3161475 D1 DE3161475 D1 DE 3161475D1 DE 8181301305 T DE8181301305 T DE 8181301305T DE 3161475 T DE3161475 T DE 3161475T DE 3161475 D1 DE3161475 D1 DE 3161475D1
Authority
DE
Germany
Prior art keywords
producing
insulin precursor
insulin
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181301305T
Other languages
English (en)
Inventor
Bruce Hill Frank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26832281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3161475(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3161475D1 publication Critical patent/DE3161475D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8181301305T 1980-03-27 1981-03-26 Process for producing an insulin precursor Expired DE3161475D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13438980A 1980-03-27 1980-03-27
US21069680A 1980-11-28 1980-11-28

Publications (1)

Publication Number Publication Date
DE3161475D1 true DE3161475D1 (en) 1983-12-29

Family

ID=26832281

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181301305T Expired DE3161475D1 (en) 1980-03-27 1981-03-26 Process for producing an insulin precursor

Country Status (23)

Country Link
EP (1) EP0037255B2 (de)
KR (1) KR840000946B1 (de)
AR (1) AR224933A1 (de)
AU (1) AU540644B2 (de)
CA (1) CA1154435A (de)
DD (1) DD157612A5 (de)
DE (1) DE3161475D1 (de)
DK (1) DK149863C (de)
EG (1) EG15310A (de)
ES (1) ES8201957A1 (de)
FI (1) FI810917L (de)
GB (1) GB2073204B (de)
GR (1) GR73517B (de)
HU (1) HU185249B (de)
IE (1) IE51172B1 (de)
IL (1) IL62486A (de)
NO (1) NO151898C (de)
NZ (1) NZ196609A (de)
PL (1) PL127843B1 (de)
PT (1) PT72732B (de)
RO (1) RO81951B (de)
SU (1) SU1301319A3 (de)
YU (1) YU76881A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183659A (ja) * 1982-03-31 1983-10-26 ジェネテイックス、インスチチュ−ト、インコ−ポレ−テッド 修飾プロインシュリン前駆体、これを暗号化するｄｎａ配列およびそれらの産生方法
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE59305396D1 (de) 1992-12-02 1997-03-20 Hoechst Ag Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten

Also Published As

Publication number Publication date
PT72732B (en) 1982-03-23
KR840000946B1 (ko) 1984-07-01
FI810917L (fi) 1981-09-28
DK149863C (da) 1987-06-01
NO811039L (no) 1981-09-28
SU1301319A3 (ru) 1987-03-30
AR224933A1 (es) 1982-01-29
NO151898C (no) 1985-06-26
PT72732A (en) 1981-04-01
GB2073204A (en) 1981-10-14
PL230292A1 (de) 1981-11-27
GR73517B (de) 1984-03-08
PL127843B1 (en) 1983-11-30
NO151898B (no) 1985-03-18
DK149863B (da) 1986-10-13
YU76881A (en) 1984-04-30
KR830005251A (ko) 1983-08-03
IE810679L (en) 1981-09-27
ES500747A0 (es) 1982-01-16
AU6871981A (en) 1981-10-01
HU185249B (en) 1984-12-28
RO81951B (ro) 1984-02-28
RO81951A (ro) 1984-02-21
CA1154435A (en) 1983-09-27
EP0037255A1 (de) 1981-10-07
ES8201957A1 (es) 1982-01-16
IE51172B1 (en) 1986-10-29
NZ196609A (en) 1984-02-03
IL62486A0 (en) 1981-05-20
DK136481A (da) 1981-09-28
AU540644B2 (en) 1984-11-29
GB2073204B (en) 1983-09-21
IL62486A (en) 1984-12-31
EG15310A (en) 1985-12-31
EP0037255B2 (de) 1989-04-05
DD157612A5 (de) 1982-11-24
EP0037255B1 (de) 1983-11-23

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Legal Events

Date Code Title Description
8366 Restricted maintained after opposition proceedings