IL62486A - Process for producing an insulin precursor having three disulfide bonds - Google Patents
Process for producing an insulin precursor having three disulfide bondsInfo
- Publication number
- IL62486A IL62486A IL62486A IL6248681A IL62486A IL 62486 A IL62486 A IL 62486A IL 62486 A IL62486 A IL 62486A IL 6248681 A IL6248681 A IL 6248681A IL 62486 A IL62486 A IL 62486A
- Authority
- IL
- Israel
- Prior art keywords
- producing
- disulfide bonds
- insulin precursor
- insulin
- precursor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13438980A | 1980-03-27 | 1980-03-27 | |
US21069680A | 1980-11-28 | 1980-11-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL62486A0 IL62486A0 (en) | 1981-05-20 |
IL62486A true IL62486A (en) | 1984-12-31 |
Family
ID=26832281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL62486A IL62486A (en) | 1980-03-27 | 1981-03-25 | Process for producing an insulin precursor having three disulfide bonds |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0037255B2 (de) |
KR (1) | KR840000946B1 (de) |
AR (1) | AR224933A1 (de) |
AU (1) | AU540644B2 (de) |
CA (1) | CA1154435A (de) |
DD (1) | DD157612A5 (de) |
DE (1) | DE3161475D1 (de) |
DK (1) | DK149863C (de) |
EG (1) | EG15310A (de) |
ES (1) | ES8201957A1 (de) |
FI (1) | FI810917L (de) |
GB (1) | GB2073204B (de) |
GR (1) | GR73517B (de) |
HU (1) | HU185249B (de) |
IE (1) | IE51172B1 (de) |
IL (1) | IL62486A (de) |
NO (1) | NO151898C (de) |
NZ (1) | NZ196609A (de) |
PL (1) | PL127843B1 (de) |
PT (1) | PT72732B (de) |
RO (1) | RO81951B (de) |
SU (1) | SU1301319A3 (de) |
YU (1) | YU76881A (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58183659A (ja) * | 1982-03-31 | 1983-10-26 | ジェネテイックス、インスチチュ−ト、インコ−ポレ−テッド | 修飾プロインシュリン前駆体、これを暗号化するdna配列およびそれらの産生方法 |
DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
DE3501641A1 (de) * | 1985-01-19 | 1986-07-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen |
DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
DE3901719A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur herstellung eines insulinvorlaeufers |
DE3901718A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern |
DE59305396D1 (de) | 1992-12-02 | 1997-03-20 | Hoechst Ag | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
US10745457B2 (en) | 2015-09-02 | 2020-08-18 | Merck Sharp & Dohme Corp. | Process for obtaining insulin with correctly formed disulfide bonds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2253327A1 (de) * | 1972-10-31 | 1974-05-09 | Hoechst Ag | Verfahren zur herstellung von insulin, insulin-analogen und -derivaten |
-
1981
- 1981-03-24 YU YU00768/81A patent/YU76881A/xx unknown
- 1981-03-24 CA CA000373692A patent/CA1154435A/en not_active Expired
- 1981-03-24 NZ NZ196609A patent/NZ196609A/en unknown
- 1981-03-24 PL PL1981230292A patent/PL127843B1/pl unknown
- 1981-03-24 RO RO103808A patent/RO81951B/ro unknown
- 1981-03-25 EG EG162/81A patent/EG15310A/xx active
- 1981-03-25 AU AU68719/81A patent/AU540644B2/en not_active Expired
- 1981-03-25 IL IL62486A patent/IL62486A/xx not_active IP Right Cessation
- 1981-03-25 FI FI810917A patent/FI810917L/fi not_active Application Discontinuation
- 1981-03-25 PT PT72732A patent/PT72732B/pt unknown
- 1981-03-26 DK DK136481A patent/DK149863C/da not_active IP Right Cessation
- 1981-03-26 GR GR64490A patent/GR73517B/el unknown
- 1981-03-26 EP EP81301305A patent/EP0037255B2/de not_active Expired
- 1981-03-26 GB GB8109543A patent/GB2073204B/en not_active Expired
- 1981-03-26 IE IE679/81A patent/IE51172B1/en not_active IP Right Cessation
- 1981-03-26 NO NO811039A patent/NO151898C/no not_active IP Right Cessation
- 1981-03-26 ES ES500747A patent/ES8201957A1/es not_active Expired
- 1981-03-26 DE DE8181301305T patent/DE3161475D1/de not_active Expired
- 1981-03-26 KR KR1019810000989A patent/KR840000946B1/ko active
- 1981-03-26 DD DD81228622A patent/DD157612A5/de unknown
- 1981-03-26 SU SU813264049A patent/SU1301319A3/ru active
- 1981-03-26 HU HU81770A patent/HU185249B/hu unknown
- 1981-03-27 AR AR284771A patent/AR224933A1/es active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
EXP | Patent expired |