KR20250099421A - 종양세포 치사활성 및 항균성 조성물 및 방법 - Google Patents

종양세포 치사활성 및 항균성 조성물 및 방법 Download PDF

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Publication number
KR20250099421A
KR20250099421A KR1020257021166A KR20257021166A KR20250099421A KR 20250099421 A KR20250099421 A KR 20250099421A KR 1020257021166 A KR1020257021166 A KR 1020257021166A KR 20257021166 A KR20257021166 A KR 20257021166A KR 20250099421 A KR20250099421 A KR 20250099421A
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South Korea
Prior art keywords
cells
culture medium
exosomes
subtype
transformed
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Pending
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KR1020257021166A
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English (en)
Korean (ko)
Inventor
한스 쥐. 클링거만
배리 제이. 시몬
Original Assignee
이뮤너티바이오, 인크.
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Application filed by 이뮤너티바이오, 인크. filed Critical 이뮤너티바이오, 인크.
Publication of KR20250099421A publication Critical patent/KR20250099421A/ko
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/44—Fungal antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2315—Interleukin-15 (IL-15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020257021166A 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법 Pending KR20250099421A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361899066P 2013-11-01 2013-11-01
US61/899,066 2013-11-01
KR1020237018562A KR20230085215A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
PCT/US2014/062695 WO2015066054A1 (en) 2013-11-01 2014-10-28 Tumoricidal and antimicrobial compositions and methods

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020237018562A Division KR20230085215A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

Publications (1)

Publication Number Publication Date
KR20250099421A true KR20250099421A (ko) 2025-07-01

Family

ID=53005034

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020257021166A Pending KR20250099421A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020217037585A Active KR102476640B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020237018562A Ceased KR20230085215A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020227036373A Ceased KR20220147705A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020167014198A Active KR102329796B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

Family Applications After (4)

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KR1020217037585A Active KR102476640B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020237018562A Ceased KR20230085215A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020227036373A Ceased KR20220147705A (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법
KR1020167014198A Active KR102329796B1 (ko) 2013-11-01 2014-10-28 종양세포 치사활성 및 항균성 조성물 및 방법

Country Status (9)

Country Link
US (10) US10258649B2 (https=)
EP (4) EP4134085B1 (https=)
JP (2) JP6603216B2 (https=)
KR (5) KR20250099421A (https=)
CN (3) CN105848662A (https=)
AU (1) AU2014342477B2 (https=)
CA (1) CA2927977C (https=)
ES (1) ES2935906T3 (https=)
WO (1) WO2015066054A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2935906T3 (es) 2013-11-01 2023-03-13 Immunitybio Inc Composiciones y métodos tumoricidas y antimicrobianos
EP3307876B1 (en) * 2015-06-10 2023-09-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
KR20180123214A (ko) * 2015-12-09 2018-11-15 난트 홀딩스 아이피, 엘엘씨 Her2 양성 전이성 유방암의 치료를 위한 조성물 및 방법
CA3030660C (en) * 2016-07-19 2023-01-17 National Institute Of Plant Genome Research Mutated protein from burkholderia gladioli strain ngj1 against fungal pathogens
JP2019532640A (ja) * 2016-09-29 2019-11-14 ナントクエスト インコーポレイテッド 免疫原性が低下したｈｌａクラスｉ欠損ｎｋ−９２細胞
CN108324735B (zh) * 2017-01-20 2024-02-09 李莉 用于疾病治疗的胞外体制剂及其应用
WO2018208702A1 (en) * 2017-05-09 2018-11-15 Saint Louis University Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes
CN111670246A (zh) * 2018-01-31 2020-09-15 南克维斯特公司 5%人白蛋白在洗涤和收获培养基中的用途
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
WO2021028787A1 (en) * 2019-08-12 2021-02-18 Advaccine (Suzhou) Biopharmaceuticals Co. Ltd. Immune composition comprising respiratory syncytial virus (rsv) g polypeptide
WO2025221993A1 (en) 2024-04-18 2025-10-23 Immunitybio, Inc. Compositions and methods for producing il-16
WO2026024752A1 (en) 2024-07-23 2026-01-29 Immunitybio, Inc. Compositions and methods related to potent cytotoxic m-cenk cells from cd3/cd14-depleted apheresis products

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US8034332B2 (en) 1997-04-30 2011-10-11 Conkwest, Inc. Interleukin-secreting natural killer cell lines and methods of use
ATE323756T1 (de) * 1997-04-30 2006-05-15 Hans Klingemann Natürliche killerzelllinien und verfahren zu ihrer verwendung
WO2005079741A1 (en) 2004-02-13 2005-09-01 Cognis France S.A.S. Cosmetic composition comprising an extract of the leaves of castanea sativa
JP2008505071A (ja) * 2004-07-02 2008-02-21 アヴァリス・アクチエボラーグ 細胞を遺伝学的に活性化する方法、および、該細胞の使用
AU2005277831B2 (en) 2004-07-10 2012-11-22 The Institute For Cancer Research Genetically modified human natural killer cell lines
BRPI0611445A2 (pt) 2005-05-09 2010-09-08 Glycart Biotechnology Ag molécula de ligação a antìgeno glicomanipulada, polinucleotìdeo, polipeptìdeo, vetor, célula hospedeira, método para produção, uso e composição farmacêutica
EP2254586B1 (en) * 2008-02-22 2015-04-08 Agency For Science, Technology And Research (A*star) Mesenchymal stem cell particles
WO2012013204A1 (en) * 2010-07-28 2012-02-02 Canvax Biotech Sl Novel ultrasensitive cell based sensors and uses thereof
KR101298012B1 (ko) 2011-02-08 2013-08-26 (주)차바이오앤디오스텍 암세포로의 표적지향을 위한 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 약학 조성물
WO2013025598A1 (en) * 2011-08-12 2013-02-21 The Children's Hospital Of Philadelphia Degranulation indicator and methods of use thereof
ES2935906T3 (es) 2013-11-01 2023-03-13 Immunitybio Inc Composiciones y métodos tumoricidas y antimicrobianos
EP3641790A1 (en) 2017-06-20 2020-04-29 Nantkwest, Inc. Methods for treating merkel cell carcinoma (mcc) using nk-92 cells
US20200306302A1 (en) 2017-08-04 2020-10-01 Nantkwest, Inc. Treating and inhibiting leukemia with nk-92 cells

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Publication number Publication date
US20190192568A1 (en) 2019-06-27
CA2927977C (en) 2024-03-05
EP3062800B1 (en) 2020-04-08
AU2014342477B2 (en) 2019-08-01
US11975027B2 (en) 2024-05-07
US20220160768A1 (en) 2022-05-26
JP6603216B2 (ja) 2019-11-06
KR20220147705A (ko) 2022-11-03
US10646516B2 (en) 2020-05-12
JP6870053B2 (ja) 2021-05-12
US20200038445A1 (en) 2020-02-06
US10258649B2 (en) 2019-04-16
KR20210144920A (ko) 2021-11-30
US20250170181A1 (en) 2025-05-29
CN121466286A (zh) 2026-02-06
JP2016539105A (ja) 2016-12-15
EP3062800A1 (en) 2016-09-07
US11213547B2 (en) 2022-01-04
EP4134085A1 (en) 2023-02-15
US20220175838A1 (en) 2022-06-09
AU2014342477A1 (en) 2016-05-26
ES2935906T3 (es) 2023-03-13
US20190192569A1 (en) 2019-06-27
US11304977B2 (en) 2022-04-19
KR20230085215A (ko) 2023-06-13
WO2015066054A1 (en) 2015-05-07
EP4134085B1 (en) 2026-04-29
EP4707383A2 (en) 2026-03-11
EP3701957B1 (en) 2022-12-28
CA2927977A1 (en) 2015-05-07
US12064450B2 (en) 2024-08-20
US20240366674A1 (en) 2024-11-07
KR102329796B1 (ko) 2021-11-23
US10772912B2 (en) 2020-09-15
US10517895B2 (en) 2019-12-31
CN105848662A (zh) 2016-08-10
US20190192570A1 (en) 2019-06-27
US20160250256A1 (en) 2016-09-01
KR20160068976A (ko) 2016-06-15
JP2020073478A (ja) 2020-05-14
CN120501764A (zh) 2025-08-19
EP3701957A1 (en) 2020-09-02
US20190125801A1 (en) 2019-05-02
EP3062800A4 (en) 2017-04-19
KR102476640B1 (ko) 2022-12-09

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