CN105848662A - 杀肿瘤和抗微生物组合物和方法 - Google Patents

杀肿瘤和抗微生物组合物和方法 Download PDF

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Publication number
CN105848662A
CN105848662A CN201480068072.8A CN201480068072A CN105848662A CN 105848662 A CN105848662 A CN 105848662A CN 201480068072 A CN201480068072 A CN 201480068072A CN 105848662 A CN105848662 A CN 105848662A
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compositions
cells
cell
pharmaceutical composition
pharmaceutical
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Chinese (zh)
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H·G·克林格曼
B·J·西蒙
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Immunitybio Inc
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NantKwest Inc
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Priority to CN202511509108.8A priority Critical patent/CN121466286A/zh
Priority to CN202510641320.3A priority patent/CN120501764A/zh
Publication of CN105848662A publication Critical patent/CN105848662A/zh
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    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/44—Fungal antigens
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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  • General Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201480068072.8A 2013-11-01 2014-10-28 杀肿瘤和抗微生物组合物和方法 Pending CN105848662A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202511509108.8A CN121466286A (zh) 2013-11-01 2014-10-28 杀肿瘤和抗微生物组合物和方法
CN202510641320.3A CN120501764A (zh) 2013-11-01 2014-10-28 杀肿瘤和抗微生物组合物和方法

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US201361899066P 2013-11-01 2013-11-01
US61/899,066 2013-11-01
PCT/US2014/062695 WO2015066054A1 (en) 2013-11-01 2014-10-28 Tumoricidal and antimicrobial compositions and methods

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CN202511509108.8A Division CN121466286A (zh) 2013-11-01 2014-10-28 杀肿瘤和抗微生物组合物和方法
CN202510641320.3A Division CN120501764A (zh) 2013-11-01 2014-10-28 杀肿瘤和抗微生物组合物和方法

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CN202511509108.8A Pending CN121466286A (zh) 2013-11-01 2014-10-28 杀肿瘤和抗微生物组合物和方法
CN202510641320.3A Pending CN120501764A (zh) 2013-11-01 2014-10-28 杀肿瘤和抗微生物组合物和方法

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US (10) US10258649B2 (https=)
EP (4) EP4134085B1 (https=)
JP (2) JP6603216B2 (https=)
KR (5) KR20250099421A (https=)
CN (3) CN105848662A (https=)
AU (1) AU2014342477B2 (https=)
CA (1) CA2927977C (https=)
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Cited By (4)

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CN108324735A (zh) * 2017-01-20 2018-07-27 李莉 用于疾病治疗的胞外体制剂及其应用
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
CN109804064A (zh) * 2016-09-29 2019-05-24 南克维斯特公司 具有降低的免疫原性的hla i类缺陷的nk-92细胞
CN111670246A (zh) * 2018-01-31 2020-09-15 南克维斯特公司 5%人白蛋白在洗涤和收获培养基中的用途

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ES2935906T3 (es) 2013-11-01 2023-03-13 Immunitybio Inc Composiciones y métodos tumoricidas y antimicrobianos
EP3307876B1 (en) * 2015-06-10 2023-09-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
KR20180123214A (ko) * 2015-12-09 2018-11-15 난트 홀딩스 아이피, 엘엘씨 Her2 양성 전이성 유방암의 치료를 위한 조성물 및 방법
CA3030660C (en) * 2016-07-19 2023-01-17 National Institute Of Plant Genome Research Mutated protein from burkholderia gladioli strain ngj1 against fungal pathogens
WO2018208702A1 (en) * 2017-05-09 2018-11-15 Saint Louis University Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes
WO2021028787A1 (en) * 2019-08-12 2021-02-18 Advaccine (Suzhou) Biopharmaceuticals Co. Ltd. Immune composition comprising respiratory syncytial virus (rsv) g polypeptide
WO2025221993A1 (en) 2024-04-18 2025-10-23 Immunitybio, Inc. Compositions and methods for producing il-16
WO2026024752A1 (en) 2024-07-23 2026-01-29 Immunitybio, Inc. Compositions and methods related to potent cytotoxic m-cenk cells from cd3/cd14-depleted apheresis products

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109804064A (zh) * 2016-09-29 2019-05-24 南克维斯特公司 具有降低的免疫原性的hla i类缺陷的nk-92细胞
CN108324735A (zh) * 2017-01-20 2018-07-27 李莉 用于疾病治疗的胞外体制剂及其应用
CN108324735B (zh) * 2017-01-20 2024-02-09 李莉 用于疾病治疗的胞外体制剂及其应用
CN111670246A (zh) * 2018-01-31 2020-09-15 南克维斯特公司 5%人白蛋白在洗涤和收获培养基中的用途
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
WO2019238120A1 (zh) * 2018-06-14 2019-12-19 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用

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US20190192568A1 (en) 2019-06-27
CA2927977C (en) 2024-03-05
EP3062800B1 (en) 2020-04-08
AU2014342477B2 (en) 2019-08-01
US11975027B2 (en) 2024-05-07
US20220160768A1 (en) 2022-05-26
JP6603216B2 (ja) 2019-11-06
KR20220147705A (ko) 2022-11-03
US10646516B2 (en) 2020-05-12
JP6870053B2 (ja) 2021-05-12
US20200038445A1 (en) 2020-02-06
US10258649B2 (en) 2019-04-16
KR20210144920A (ko) 2021-11-30
US20250170181A1 (en) 2025-05-29
CN121466286A (zh) 2026-02-06
JP2016539105A (ja) 2016-12-15
EP3062800A1 (en) 2016-09-07
US11213547B2 (en) 2022-01-04
EP4134085A1 (en) 2023-02-15
US20220175838A1 (en) 2022-06-09
AU2014342477A1 (en) 2016-05-26
ES2935906T3 (es) 2023-03-13
US20190192569A1 (en) 2019-06-27
US11304977B2 (en) 2022-04-19
KR20230085215A (ko) 2023-06-13
WO2015066054A1 (en) 2015-05-07
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