ES2935906T3 - Composiciones y métodos tumoricidas y antimicrobianos - Google Patents
Composiciones y métodos tumoricidas y antimicrobianos Download PDFInfo
- Publication number
- ES2935906T3 ES2935906T3 ES20159448T ES20159448T ES2935906T3 ES 2935906 T3 ES2935906 T3 ES 2935906T3 ES 20159448 T ES20159448 T ES 20159448T ES 20159448 T ES20159448 T ES 20159448T ES 2935906 T3 ES2935906 T3 ES 2935906T3
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- Prior art keywords
- cells
- pharmaceutical composition
- exosomes
- microvesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/44—Fungal antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361899066P | 2013-11-01 | 2013-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2935906T3 true ES2935906T3 (es) | 2023-03-13 |
Family
ID=53005034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES20159448T Active ES2935906T3 (es) | 2013-11-01 | 2014-10-28 | Composiciones y métodos tumoricidas y antimicrobianos |
Country Status (9)
| Country | Link |
|---|---|
| US (10) | US10258649B2 (https=) |
| EP (4) | EP4134085B1 (https=) |
| JP (2) | JP6603216B2 (https=) |
| KR (5) | KR102329796B1 (https=) |
| CN (3) | CN121466286A (https=) |
| AU (1) | AU2014342477B2 (https=) |
| CA (1) | CA2927977C (https=) |
| ES (1) | ES2935906T3 (https=) |
| WO (1) | WO2015066054A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4134085B1 (en) | 2013-11-01 | 2026-04-29 | ImmunityBio, Inc. | Tumoricidal and antimicrobial compositions and methods |
| EP4424326A3 (en) | 2015-06-10 | 2024-11-13 | ImmunityBio, Inc. | Modified nk-92 cells for treating cancer |
| WO2017100709A1 (en) * | 2015-12-09 | 2017-06-15 | Nant Holdings Ip, Llc | Compositions and methods for treatment of her2 positive metastatic breast cancer |
| US11142552B2 (en) * | 2016-07-19 | 2021-10-12 | National Institute Of Plant Genome Research | Protein against fungal pathogens |
| WO2018064594A2 (en) * | 2016-09-29 | 2018-04-05 | Nantkwest, Inc. | Hla class i-deficient nk-92 cells with decreased immunogenicity |
| CN108324735B (zh) * | 2017-01-20 | 2024-02-09 | 李莉 | 用于疾病治疗的胞外体制剂及其应用 |
| US20200163993A1 (en) * | 2017-05-09 | 2020-05-28 | Saint Louis University | Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes |
| US20210040451A1 (en) * | 2018-01-31 | 2021-02-11 | Nantkwest, Inc. | Use of 5% human albumin in wash and harvest media |
| CN108815186A (zh) * | 2018-06-14 | 2018-11-16 | 上海鸣大生物科技有限公司 | 一种治疗hpv持续感染引起疾病的药物及制备方法与应用 |
| EP4013782A4 (en) * | 2019-08-12 | 2023-12-27 | Advaccine (Suzhou) Biopharmaceuticals Co. Ltd. | IMMUNE COMPOSITION COMPRISING A RESPIRATORY SYNCYTIAL VIRUS (RSV) POLYPEPTIDE G |
| WO2025221993A1 (en) | 2024-04-18 | 2025-10-23 | Immunitybio, Inc. | Compositions and methods for producing il-16 |
| US20260027155A1 (en) | 2024-07-23 | 2026-01-29 | Immunitybio, Inc. | Compositions and methods related to potent cytotoxic m-cenk cells from cd3/cd14-depleted apheresis products |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7267398A (en) * | 1997-04-30 | 1998-11-24 | Hans Klingemann | Natural killer cell lines and methods of use |
| US8034332B2 (en) | 1997-04-30 | 2011-10-11 | Conkwest, Inc. | Interleukin-secreting natural killer cell lines and methods of use |
| US8067044B2 (en) | 2004-02-13 | 2011-11-29 | Cognis France S.A.S. | Cosmetic compositions containing an extract of leaves of the Castanea sativa plant and cosmetic treatments |
| WO2006004518A1 (en) | 2004-07-02 | 2006-01-12 | Avaris Ab | Method for the genetic activation of cells and uses of said cells |
| DE602005016683D1 (de) | 2004-07-10 | 2009-10-29 | Fox Chase Cancer Ct | Genetisch modifizierte, menschliche, natürliche killerzellenlinien: |
| JP2008539753A (ja) | 2005-05-09 | 2008-11-20 | グリクアート バイオテクノロジー アクチェンゲゼルシャフト | 修飾ｆｃ領域およびｆｃ受容体との結合変更を有する抗原結合分子 |
| CN102014934B (zh) | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| WO2012013204A1 (en) * | 2010-07-28 | 2012-02-02 | Canvax Biotech Sl | Novel ultrasensitive cell based sensors and uses thereof |
| KR101298012B1 (ko) | 2011-02-08 | 2013-08-26 | (주)차바이오앤디오스텍 | 암세포로의 표적지향을 위한 자연살해 세포를 포함하는 림프구의 제조방법 및 이를 포함하는 약학 조성물 |
| US20150212064A1 (en) * | 2011-08-12 | 2015-07-30 | The Childrens's Hospital Of Philadelphia | Degranulation indicator and methods of use thereof |
| EP4134085B1 (en) | 2013-11-01 | 2026-04-29 | ImmunityBio, Inc. | Tumoricidal and antimicrobial compositions and methods |
| JP2020524164A (ja) | 2017-06-20 | 2020-08-13 | ナントクエスト インコーポレイテッド | Ｎｋ−９２細胞を用いてメルケル細胞癌（ｍｃｃ）を治療するための方法 |
| KR20200035999A (ko) | 2017-08-04 | 2020-04-06 | 난트케이웨스트, 인크. | Nk-92 세포를 이용한 백혈병의 치료 및 억제 |
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2014
- 2014-10-28 EP EP22197465.2A patent/EP4134085B1/en active Active
- 2014-10-28 EP EP26153551.2A patent/EP4707383A2/en active Pending
- 2014-10-28 WO PCT/US2014/062695 patent/WO2015066054A1/en not_active Ceased
- 2014-10-28 KR KR1020167014198A patent/KR102329796B1/ko active Active
- 2014-10-28 KR KR1020217037585A patent/KR102476640B1/ko active Active
- 2014-10-28 AU AU2014342477A patent/AU2014342477B2/en active Active
- 2014-10-28 KR KR1020237018562A patent/KR20230085215A/ko not_active Ceased
- 2014-10-28 US US15/032,518 patent/US10258649B2/en active Active
- 2014-10-28 CN CN202511509108.8A patent/CN121466286A/zh active Pending
- 2014-10-28 CN CN202510641320.3A patent/CN120501764A/zh active Pending
- 2014-10-28 KR KR1020257021166A patent/KR20250099421A/ko active Pending
- 2014-10-28 CA CA2927977A patent/CA2927977C/en active Active
- 2014-10-28 CN CN201480068072.8A patent/CN105848662A/zh active Pending
- 2014-10-28 KR KR1020227036373A patent/KR20220147705A/ko not_active Ceased
- 2014-10-28 JP JP2016527424A patent/JP6603216B2/ja active Active
- 2014-10-28 EP EP20159448.8A patent/EP3701957B1/en active Active
- 2014-10-28 EP EP14858835.3A patent/EP3062800B1/en active Active
- 2014-10-28 ES ES20159448T patent/ES2935906T3/es active Active
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2018
- 2018-12-06 US US16/212,578 patent/US10646516B2/en active Active
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2019
- 2019-02-28 US US16/289,512 patent/US10772912B2/en active Active
- 2019-02-28 US US16/289,494 patent/US10517895B2/en active Active
- 2019-02-28 US US16/289,526 patent/US11213547B2/en active Active
- 2019-10-10 US US16/598,418 patent/US11304977B2/en active Active
- 2019-10-10 JP JP2019186716A patent/JP6870053B2/ja active Active
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2021
- 2021-11-30 US US17/539,155 patent/US11975027B2/en active Active
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2022
- 2022-02-22 US US17/677,727 patent/US12064450B2/en active Active
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2024
- 2024-07-17 US US18/775,316 patent/US20240366674A1/en active Pending
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2025
- 2025-01-17 US US19/030,104 patent/US20250170181A1/en active Pending
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